Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β.
Bibhuti B. Mishra,Vijay A. K. Rathinam,Gregory W. Martens,Amanda J. Martinot,Hardy Kornfeld,Katherine A. Fitzgerald,Christopher M. Sassetti,Christopher M. Sassetti +7 more
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TLDR
By exogenously controlling the replication of Mycobacterium tuberculosis in vivo, the requirement for antimicrobial immunity is obviated and it is discovered that both IL-1 production and infection-induced immunopathology were suppressed by lymphocyte-derived interferon-γ (IFN-γ).Abstract:
Interleukin 1 (IL-1) is an important mediator of innate immunity but can also promote inflammatory tissue damage. During chronic infections such as tuberculosis, the beneficial antimicrobial role of IL-1 must be balanced with the need to prevent immunopathology. By exogenously controlling the replication of Mycobacterium tuberculosis in vivo, we obviated the requirement for antimicrobial immunity and discovered that both IL-1 production and infection-induced immunopathology were suppressed by lymphocyte-derived interferon-γ (IFN-γ). This effect was mediated by nitric oxide (NO), which we found specifically inhibited assembly of the NLRP3 inflammasome via thiol nitrosylation. Our data indicate that the NO produced as a result of adaptive immunity is indispensable in modulating the destructive innate inflammatory responses elicited during persistent infections.read more
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Mechanisms of Macrophage Immunomodulatory Activity Induced by a New Polysaccharide Isolated From Polyporus umbellatus (Pers.) Fries.
Chun-Ping Liu,Xiong Li,Gena Lai,Jin-Hua Li,Wenyu Jia,Ying-Ying Cao,Wen-Xing Xu,Qing-Long Tan,Chang-Yuan Zhou,Min Luo,Xue-Ying Zhang,Dao-Qing Yuan,Jin-Ying Tian,Xian Zhang,Xing Zeng +14 more
TL;DR: It is demonstrated that HPP may be a potential immune modulator in the treatment of immunological diseases or bladder cancer therapy and could enhance host immune system function.
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Assessment of the antinociceptive, antiinflammatory and acute toxicity effects of Ducrosia anethifolia essential oil in mice
TL;DR: Intraperitoneal administration of Ducrosia anethifolia leaf essential oil can produce analgesic and antiinflammatory effects.
Journal ArticleDOI
Tanshinone IIA alleviates NLRP3 inflammasome-mediated pyroptosis in Mycobacterium tuberculosis-(H37Ra-) infected macrophages by inhibiting endoplasmic reticulum stress
TL;DR: Tan IIA (Tan) extracts from Salvia miltiorrhiza Bunge are extracted from Asian countries to examine the anti-inflammatory effects of Tan as discussed by the authors . And Tan may function as an adjuvant drug to treat TB by adjusting host immune responses.
Journal ArticleDOI
Interaction of Mycobacteria With Host Cell Inflammasomes
Shivangi Rastogi,Volker Briken +1 more
TL;DR: There is good evidence for a tug-of-war between Mtb trying to limit inflammasome activation and the host cell trying to sense Mtb and activate the inflammaome.
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Contribution of Toll-Like Receptors and the NLRP3 Inflammasome in Rheumatoid Arthritis Pathophysiology.
TL;DR: In this article, a review summarizes the current understanding of the potential involvement of toll-like receptors in the initiation and maintenance of inflammation and tissue damage in RA and experimental arthritis models, including the nucleotide-binding domain and leucine-rich repeat pyrin containing protein-3 (NLRP3) inflammasome.
References
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Journal ArticleDOI
AIM2 recognizes cytosolic dsDNA and forms a caspase-1 activating inflammasome with ASC
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TL;DR: Using mouse and human cells, the PYHIN (pyrin and HIN domain-containing protein) family member absent in melanoma 2 (AIM2) is identified as a receptor for cytosolic DNA, which regulates caspase-1.
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Erratum: NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals (Nature (2010) 464 (1357-1361))
Peter Duewell,Hajime Kono,Katey J. Rayner,Cherilyn M. Sirois,Gregory I. Vladimer,Franz Bauernfeind,George S. Abela,Luigi Franchi,Gabriel Núñez,Max Schnurr,Terje Espevik,Egil Lien,Katherine A. Fitzgerald,Kenneth L. Rock,Kathryn J. Moore,Samuel D. Wright,Veit Hornung,Eicke Latz +17 more
TL;DR: This corrects the article to show that the method used to derive the H2O2 “spatially aggregating force” is a two-step process, not a single step, like in the previous version of this paper.
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