Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β.
Bibhuti B. Mishra,Vijay A. K. Rathinam,Gregory W. Martens,Amanda J. Martinot,Hardy Kornfeld,Katherine A. Fitzgerald,Christopher M. Sassetti,Christopher M. Sassetti +7 more
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TLDR
By exogenously controlling the replication of Mycobacterium tuberculosis in vivo, the requirement for antimicrobial immunity is obviated and it is discovered that both IL-1 production and infection-induced immunopathology were suppressed by lymphocyte-derived interferon-γ (IFN-γ).Abstract:
Interleukin 1 (IL-1) is an important mediator of innate immunity but can also promote inflammatory tissue damage. During chronic infections such as tuberculosis, the beneficial antimicrobial role of IL-1 must be balanced with the need to prevent immunopathology. By exogenously controlling the replication of Mycobacterium tuberculosis in vivo, we obviated the requirement for antimicrobial immunity and discovered that both IL-1 production and infection-induced immunopathology were suppressed by lymphocyte-derived interferon-γ (IFN-γ). This effect was mediated by nitric oxide (NO), which we found specifically inhibited assembly of the NLRP3 inflammasome via thiol nitrosylation. Our data indicate that the NO produced as a result of adaptive immunity is indispensable in modulating the destructive innate inflammatory responses elicited during persistent infections.read more
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Knockout of NOS2 Promotes Adipogenic Differentiation of Rat MSCs by Enhancing Activation of JAK/STAT3 Signaling
Aiping Qin,Sheng Chen,Ping Wang,Xiaotao Huang,Yu Zhang,Lu Liang,Lingran Du,De-Hua Lai,Li Ding,Xi-Yong Yu,Andy Peng Xiang +10 more
TL;DR: In this article, the role of NO synthase 2 (NOS2) on adipogenic and osteogenic differentiation of rat mesenchymal stromal cells (MSCs) was investigated.
Journal ArticleDOI
Deficiency of the Intramembrane Protease SPPL2a Alters Antimycobacterial Cytokine Responses of Dendritic Cells.
Ann-Christine Gradtke,Torben Mentrup,Christian H. K. Lehmann,Florencia Cabrera-Cabrera,Florencia Cabrera-Cabrera,Christine Desel,Darian Okakpu,Maike Assmann,Alexander H. Dalpke,Ulrich E. Schaible,Diana Dudziak,Bernd Schröder +11 more
TL;DR: SPPL2a deficiency alters pattern recognition receptor pathways in a CD74-dependent way, shifting the balance from anti- to proinflammatory cytokines in antimycobacterial responses.
MonographDOI
Mycobacterium tuberculosis and the human macrophage : shifting the balance through inflammasome activation
TL;DR: Mycobacterium tuberculosis is a very successful pathogen and tuberculosis constitutes a major threat to global health worldwide.
Journal ArticleDOI
NLRP3 activated macrophages promote endometrial stromal cells migration in endometriosis.
TL;DR: In this paper , peritoneal fluid samples from women with EMs show defectively activated macrophages (MΦs) and strong NOD-like receptor family pyrin domain containing 3 (NLRP3) expression.
Journal ArticleDOI
Protein Kinase R in Bacterial Infections: Friend or Foe?
Robin Smyth,Jim Sun +1 more
TL;DR: An overview of immune cell functions regulated by PKR is provided and the current knowledge on the role and functions of PKR in bacterial infections is summarized and existing pharmacological modulators of PKr that could be explored as novel treatment strategies for bacterial infections are provided.
References
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Journal ArticleDOI
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Journal ArticleDOI
Erratum: NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals (Nature (2010) 464 (1357-1361))
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TL;DR: This corrects the article to show that the method used to derive the H2O2 “spatially aggregating force” is a two-step process, not a single step, like in the previous version of this paper.
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