Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β.
Bibhuti B. Mishra,Vijay A. K. Rathinam,Gregory W. Martens,Amanda J. Martinot,Hardy Kornfeld,Katherine A. Fitzgerald,Christopher M. Sassetti,Christopher M. Sassetti +7 more
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TLDR
By exogenously controlling the replication of Mycobacterium tuberculosis in vivo, the requirement for antimicrobial immunity is obviated and it is discovered that both IL-1 production and infection-induced immunopathology were suppressed by lymphocyte-derived interferon-γ (IFN-γ).Abstract:
Interleukin 1 (IL-1) is an important mediator of innate immunity but can also promote inflammatory tissue damage. During chronic infections such as tuberculosis, the beneficial antimicrobial role of IL-1 must be balanced with the need to prevent immunopathology. By exogenously controlling the replication of Mycobacterium tuberculosis in vivo, we obviated the requirement for antimicrobial immunity and discovered that both IL-1 production and infection-induced immunopathology were suppressed by lymphocyte-derived interferon-γ (IFN-γ). This effect was mediated by nitric oxide (NO), which we found specifically inhibited assembly of the NLRP3 inflammasome via thiol nitrosylation. Our data indicate that the NO produced as a result of adaptive immunity is indispensable in modulating the destructive innate inflammatory responses elicited during persistent infections.read more
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Dissertation
Macrophage immunometabolism in the host response to Mycobacterium tuberculosis infection
Journal ArticleDOI
Mycobacterium tuberculosis strain 18b, a useful non-virulent streptomycin dependent mutant to study latent tuberculosis as well as for in vivo and in vitro testing of anti-tuberculosis drugs.
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Mycobacterium tuberculosis stimulates IL-1β production by macrophages in an ESAT-6 dependent manner with the involvement of serum amyloid A3
TL;DR: In this paper, the molecular details of interleukin (IL)-1β production in tuberculosis infection remain elusive, despite its critical roles in immune responses against tuberculosis infection and immune pathology.
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Nitric oxide-sensitized mitoxantrone chemotherapy integrated with photothermal therapy against multidrug-resistant tumors
Xiaoyu Huang,Xiaoyu Huang,Rui Gu,Zhihao Zhong,Changjin Ou,Weili Si,Fu Wang,Ting Zhang,Xiaochen Dong +8 more
TL;DR: A versatile two-dimensional nanoplatform (N-GO-MTX-BNN6 NPs) can achieve nitric oxide-sensitized mitoxantrone chemotherapy integrated with photothermal therapy to fight MCF-7/ADR tumor cells.
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MicroRNAs as immune regulators and biomarkers in tuberculosis
TL;DR: It is stated that pathogens can exploit interactions between miRNAs and other biomolecules to avoid host mechanisms of immune-mediated clearance and survive in host cells for a long time.
References
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TL;DR: This corrects the article to show that the method used to derive the H2O2 “spatially aggregating force” is a two-step process, not a single step, like in the previous version of this paper.
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