Journal ArticleDOI
Of cascades and perfect storms : the immunopathogenesis of dengue haemorrhagic fever-dengue shock syndrome (DHF/DSS)
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TLDR
Advances have underscored the fact that DHF/DSS pathogenesis is a complex, multifactorial process involving cocirculation of various dengue virus serotypes and the interplay of host and viral factors that influence disease severity.Abstract:
The past four decades has witnessed a consolidation of the original observations made in the 1970s that dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS) have an immunological basis. Following reinfection with a dengue virus of different serotype, severe disease is linked to high levels of antibody-enhanced viral replication early in illness which is followed by a cascade of memory T-cell activation and a 'storm' of inflammatory cytokines and other chemical mediators. These compounds are released mainly from T cells, monocytes/macrophages and endothelial cells, and ultimately cause an increase in vascular permeability. The consolidation of the evidence has been largely due to several important prospective sero-epidemiological studies in areas endemic for DHF/DSS, which have shown that risk of severe disease is significantly higher in secondary dengue infections. These advances have underscored the fact that DHF/DSS pathogenesis is a complex, multifactorial process involving cocirculation of various dengue virus serotypes and the interplay of host and viral factors that influence disease severity. The continued search to define risk factors in susceptible populations must be combined with the new techniques of molecular virology and innovative approaches in vaccine design to achieve the ultimate objective of developing a safe and effective vaccine.read more
Citations
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Journal ArticleDOI
The mannose receptor mediates dengue virus infection of macrophages.
Joanna L. Miller,Barend J. M deWet,Luisa Martinez-Pomares,Catherine M. Radcliffe,Raymond A. Dwek,Pauline M. Rudd,Siamon Gordon +6 more
TL;DR: It is shown for the first time that the MØ mannose receptor binds to all four serotypes of DV and specifically to the envelope glycoprotein, indicating a new functional role for the MR in DV infection.
Journal ArticleDOI
MAIT cells are activated during human viral infections
B van Wilgenburg,I Scherwitzl,Edward C. Hutchinson,Tianqi Leng,Ayako Kurioka,C Kulicke,C de Lara,S L Cole,Sirijitt Vasanawathana,Wannee Limpitikul,Prida Malasit,Duncan Young,Laura Denney,Moore,Paolo Fabris,Maria Teresa Giordani,Ye Htun Oo,Stephen M. Laidlaw,Lynn B. Dustin,Ho L-P.,Fiona M. Thompson,Narayan Ramamurthy,Juthathip Mongkolsapaya,Christian B. Willberg,Gavin R. Screaton,Paul Klenerman +25 more
TL;DR: It is demonstrated that MAIT cells are activated following viral infections, and a potential role in both host defence and immunopathology is suggested.
Journal ArticleDOI
CLEC5A is critical for dengue-virus-induced lethal disease.
Szu Ting Chen,Yi-Ling Lin,Ming Ting Huang,Ming Fang Wu,Shih-Chin Cheng,Huan Yao Lei,Chien-Kuo Lee,Tzyy-Wen Chiou,Chi-Huey Wong,Shie-Liang Hsieh,Shie-Liang Hsieh,Shie-Liang Hsieh +11 more
TL;DR: The observation that blockade of CLEC5A-mediated signalling attenuates the production of proinflammatory cytokines by macrophages infected with DV offers a promising strategy for alleviating tissue damage and increasing the survival of patients suffering from d Dengue haemorrhagic fever and dengue shock syndrome, and possibly even other virus-induced inflammatory diseases.
Journal ArticleDOI
Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity
Fernando A. Bozza,Oswaldo Gonçalves Cruz,Sonia M O Zagne,Elzinandes Leal de Azeredo,Rita Maria Ribeiro Nogueira,Edson F. Assis,Patrícia T. Bozza,Claire Fernandes Kubelka +7 more
TL;DR: The use of a multiple cytokine assay platform was suitable for identifying distinct cytokine profiles associated with the dengue clinical manifestations and severity and MIP-β is indicated for the first time as a good prognostic marker in contrast to IFN-γ that was associated with disease severity.
Journal ArticleDOI
Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation
Eugenio D. Hottz,Juliana F. Lopes,Carla Freitas,Rogério Valls-de-Souza,Marcus F. Oliveira,Marcelo T. Bozza,Andrea T. Da Poian,Andrew S. Weyrich,Guy A. Zimmerman,Fernando A. Bozza,Patrícia T. Bozza +10 more
TL;DR: Investigation of interleukin (IL)-1β synthesis, processing, and secretion in platelets during dengue virus (DV) infection and potential contribution of these events to endothelial permeability during infection finds that platelets contribute to increased vascular permeability in DV infection by inflammasome-dependent release of IL-1β.
References
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