Book ChapterDOI
Neutralization and antibody-dependent enhancement of dengue viruses.
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This chapter highlights the neutralization and protection against dengue infection by antibodies and relevant clinical and epidemiological and experimental studies that support the phenomenon of antibody-dependent enhanced (ADE) are discussed.Abstract:
Publisher Summary This chapter highlights the neutralization and protection against dengue infection by antibodies and relevant clinical and epidemiological and experimental studies that support the phenomenon of antibody-dependent enhanced (ADE) are discussed Epidemiological studies provide the background evidence that shows ADE to be a biologically plausible hypothesis Several mechanisms have been proposed for the neutralization of viruses in vivo : aggregation of viruses resulting in elimination by phagocytic cells; blocked attachment to one or another cell receptor by (a) stearic interference, (b) capsid stabilization, or (c) structural changes; or neutralization of uncoating due to (a) capsid stabilization or (b) interference with fusionread more
Citations
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Journal ArticleDOI
Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection
Karin Stettler,Martina Beltramello,Diego A. Espinosa,Victoria A. Graham,Antonino Cassotta,Antonino Cassotta,Siro Bianchi,Fabrizia Vanzetta,Andrea Minola,Stefano Jaconi,Federico Mele,Mathilde Foglierini,Mattia Pedotti,Luca Simonelli,Stuart D. Dowall,Barry Atkinson,Elena Percivalle,Cameron P. Simmons,Cameron P. Simmons,Luca Varani,Johannes Blum,Johannes Blum,Fausto Baldanti,Elisabetta Cameroni,Roger Hewson,Eva Harris,Antonio Lanzavecchia,Antonio Lanzavecchia,Federica Sallusto,Davide Corti +29 more
TL;DR: The most potent neutralizing antibodies were ZIKV-specific and targeted EDIII or quaternary epitopes on infectious virus, and an EDIII-targeted antibody protected mice against lethal infection, illustrating the potential for antibody-based therapy.
Journal ArticleDOI
Prospects for a dengue virus vaccine.
TL;DR: The unique immunological concerns in dengue virus vaccine development are discussed and the current prospects for the development of an acceptable vaccine are discussed, with a goal that is likely to be reached in the near future.
Journal ArticleDOI
The Human Immune Response to Dengue Virus Is Dominated by Highly Cross-Reactive Antibodies Endowed with Neutralizing and Enhancing Activity
Martina Beltramello,Katherine L. Williams,Cameron P. Simmons,Annalisa Macagno,Luca Simonelli,Nguyen Than Ha Quyen,Soila Sukupolvi-Petty,Erika Navarro-Sanchez,Paul R. Young,Aravinda M. de Silva,Félix A. Rey,Luca Varani,Stephen S. Whitehead,Michael S. Diamond,Eva Harris,Antonio Lanzavecchia,Federica Sallusto +16 more
TL;DR: These findings reveal an unexpected degree of cross-reactivity in human antibodies against DENV and illustrate the potential for an antibody-based therapy to control severe dengue.
Journal ArticleDOI
Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies.
TL;DR: Key ADE mechanisms are described and mitigation strategies for SARS-CoV-2 vaccines and therapies in development are discussed and recently published data is outlined to evaluate the risks and opportunities for antibody-based protection against Sars-Cov-2.
Journal ArticleDOI
Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus
Lalita Priyamvada,Kendra M. Quicke,William H. Hudson,Nattawat Onlamoon,Jaturong Sewatanon,Srilatha Edupuganti,Kovit Pattanapanyasat,Kulkanya Chokephaibulkit,Mark J. Mulligan,Patrick C. Wilson,Rafi Ahmed,Mehul S. Suthar,Jens Wrammert +12 more
TL;DR: It is shown that both acute and convalescent dengue sera potently bind and neutralize ZIKV and that this cross-reactivity is also evident at the monoclonal level, suggesting that preexisting immunity to DENV may impact protective immune responses against ZikV.
References
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Journal ArticleDOI
Pathogenesis of dengue: challenges to molecular biology
TL;DR: This work has identified a severe syndrome, dengue hemorrhagic fever/dengue shock syndrome, in Southeast Asian children, which recently has also been identified in children infected with the virus in Puerto Rico.
Journal ArticleDOI
Dengue Viremia Titer, Antibody Response Pattern, and Virus Serotype Correlate with Disease Severity
David W. Vaughn,Sharone Green,Siripen Kalayanarooj,Bruce L. Innis,Suchitra Nimmannitya,Saroj Suntayakorn,Timothy P. Endy,Boonyos Raengsakulrach,Alan L. Rothman,Francis A. Ennis,Ananda Nisalak +10 more
TL;DR: Higher peak titers were associated with increased disease severity for the 31 patients with a peak titer identified, and increased dengue disease severity correlated with high viremia titer, secondary d Dengue virus infection, and DEN-2 virus type.
Journal ArticleDOI
Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate
Yaping Chen,Terry Maguire,Ronald E. Hileman,Jonathan R. Fromm,Jeffrey D. Esko,Robert J. Linhardt,Rory M. Marks +6 more
TL;DR: Heparin, highly sulfated heparan sulfate, and the polysulfonate pharmaceutical Suramin effectively prevented dengue virus infection of target cells, indicating that the envelope protein-target cell receptor interaction is a critical determinant of infectivity.
Journal ArticleDOI
Research on dengue during World War II.
TL;DR: Dengue research was brought from the field into the laboratory and further progress has been made possible by work on experimental animals instead of on human volunteers, and a great deal more was learned about the basic properties of the dengue viruses.
Journal ArticleDOI
A prospective study of dengue infections in Bangkok.
TL;DR: Preexistent d Dengue immunity, as detected by conventional serologic techniques, was a significant (odds ratio greater than or equal to 6.5) risk factor for development of dengue hemorrhagic fever.
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