Orally disintegrating films: A modern expansion in drug delivery system.
Muhammad Irfan,Sumeira Rabel,Quratulain Bukhtar,Muhammad Imran Qadir,Farhat Jabeen,Ahmed Khan +5 more
TLDR
Orally disintegrating films have potential for business and market exploitation because of their myriad of benefits over orally disintegrating tablets and the market prospect of this innovative dosage form is also targeted.Abstract:
Over the past few decades, tendency toward innovative drug delivery systems has majorly increased attempts to ensure efficacy, safety and patient acceptability. As discovery and development of new chemical agents is a complex, expensive and time consuming process, so recent trends are shifting toward designing and developing innovative drug delivery systems for existing drugs. Out of those, drug delivery system being very eminent among pediatrics and geriatrics is orally disintegrating films (ODFs). These fast disintegrating films have superiority over fast disintegrating tablets as the latter are associated with the risks of choking and friability. This drug delivery system has numerous advantages over conventional fast disintegrating tablets as they can be used for dysphasic and schizophrenic patients and are taken without water due to their ability to disintegrate within a few seconds releasing medication in mouth. Various approaches are employed for formulating ODFs and among which solvent casting and spraying methods are frequently used. Generally, hydrophilic polymers along with other excipients are used for preparing ODFs which allow films to disintegrate quickly releasing incorporated active pharmaceutical ingredient (API) within seconds. Orally disintegrating films have potential for business and market exploitation because of their myriad of benefits over orally disintegrating tablets. This present review attempts to focus on benefits, composition, approaches for formulation and evaluation of ODFs. Additionally, the market prospect of this innovative dosage form is also targeted.read more
Citations
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Journal ArticleDOI
A Comprehensive Review: Natural Polymers Used for Fast Dissolving Mouth Film
TL;DR: In this article, various polymers are utilized for the formulation of fast dissolving mouth film like Pullulan, Gelatin, Sodium Alginate, Pectin, Rosin, Starch, Chitosan are discussed together about their physicochemical properties and film shaping properties.
Journal IssueDOI
Development and Evaluation of Fast‑Dissolving Oral Film of Poorly Water-Soluble Drug Felodipine
TL;DR: It was concluded that fast-dissolving oral film containing SDP of drug may provide the merits of faster onset of action, avoidance of extensive first-pass metabolism, enhanced bioavailability, and improved patient compliance for the delivery of poorly water-soluble drug such as Felodipine.
Dissertation
Development of novel pharmaceutical forms for oral administration of bioactive agents
TL;DR: Tese de doutoramento em Ciencias Farmaceuticas, na especialidade de Tecnologia Farmaceutica, apresentada a Faculdade de Farmacia da Universidade DE Coimbra as mentioned in this paper
Journal ArticleDOI
Development of hyaluronic acid-based edible film for alleviating dry mouth
TL;DR: For alleviating dry mouth symptoms, edible films based on hyaluronic acid (HA) with three different mw (800, 1200 and 2300 kDa) were prepared, and the properties as well as effectiveness were compared as discussed by the authors .
Journal ArticleDOI
Oromucosal Alginate Films with Zein Nanoparticles as a Novel Delivery System for Digoxin
Daniela A. Rodrigues,Sónia P. Miguel,Jorge Loureiro,Maximiano P. Ribeiro,Fátima Roque,Paula Coutinho +5 more
TL;DR: In this article, the authors demonstrate the potential of the SA films as buccal drug delivery system containing zein nanoparticles incorporated with digoxin to reduce the number of doses, facilitating the administration with a quick onset of action.
References
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Fast dissolving films made of maltodextrins.
TL;DR: This work aimed to study maltodextrins (MDX) with a low dextrose equivalent as film forming material and their application in the design of oral fast-dissolving films, and the MDX/plasticizer interactions were investigated by ATR-FTIR spectroscopy.
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Orally dissolving strips: A new approach to oral drug delivery system
TL;DR: As the drug is directly absorbed into systemic circulation, degradation in gastrointestinal tract and first pass effect can be avoided, these points make this formulation most popular and acceptable among pediatric and geriatric patients and patients with fear of choking.
Journal ArticleDOI
Formulation and evaluation of fast dissolving films for delivery of triclosan to the oral cavity.
TL;DR: Eugenol containing films improved the acceptability of TC-Poloxamer 407 films with respect to taste masking and mouth freshening without compromising the in vivo dissolution time.
A Short Review on "A Novel Approach in Oral Fast Dissolving Drug Delivery System and Their Patents"
Garima Garg,Pankaj Sharma +1 more
TL;DR: The oral thin-film technology is still in the beginning stages and has bright future ahead because it fulfils all the need of patients, and for future growth point of view the oral thin film sector is well-positioned.
Journal ArticleDOI
Orally disintegrating systems: innovations in formulation and technology.
TL;DR: This article attempts at discussing the patents relating to orally disintegrating systems with respect to the use of different formulation ingredients and technologies.