Orally disintegrating films: A modern expansion in drug delivery system.
Muhammad Irfan,Sumeira Rabel,Quratulain Bukhtar,Muhammad Imran Qadir,Farhat Jabeen,Ahmed Khan +5 more
TLDR
Orally disintegrating films have potential for business and market exploitation because of their myriad of benefits over orally disintegrating tablets and the market prospect of this innovative dosage form is also targeted.Abstract:
Over the past few decades, tendency toward innovative drug delivery systems has majorly increased attempts to ensure efficacy, safety and patient acceptability. As discovery and development of new chemical agents is a complex, expensive and time consuming process, so recent trends are shifting toward designing and developing innovative drug delivery systems for existing drugs. Out of those, drug delivery system being very eminent among pediatrics and geriatrics is orally disintegrating films (ODFs). These fast disintegrating films have superiority over fast disintegrating tablets as the latter are associated with the risks of choking and friability. This drug delivery system has numerous advantages over conventional fast disintegrating tablets as they can be used for dysphasic and schizophrenic patients and are taken without water due to their ability to disintegrate within a few seconds releasing medication in mouth. Various approaches are employed for formulating ODFs and among which solvent casting and spraying methods are frequently used. Generally, hydrophilic polymers along with other excipients are used for preparing ODFs which allow films to disintegrate quickly releasing incorporated active pharmaceutical ingredient (API) within seconds. Orally disintegrating films have potential for business and market exploitation because of their myriad of benefits over orally disintegrating tablets. This present review attempts to focus on benefits, composition, approaches for formulation and evaluation of ODFs. Additionally, the market prospect of this innovative dosage form is also targeted.read more
Citations
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Effect of the new 75-mg orodispersible film of sildenafil on erection and sexual quality of life: insights from an observational study
Andrea Sansone,V. Frangione,Arturo Lanzarotti,Andrea Bocci,Carlo Ceruti,Marco De Sio,Ciro Imbimbo,Vincenzo Mirone,Luigi Schips,Carlo Terrone,Emmanuele A. Jannini +10 more
TL;DR: In this paper , the effects of the sildenafil ODF 75-mg dose on both sexual quality of life and erectile function based on the results from an observational study in daily practice in Italy were investigated.
Journal ArticleDOI
Review on: Recent advances in mouth dissolving film
Pawan S. Avhad,Saurabh D. Nikam,Amit A. Chaudhari,Shital Vishnu Wagh,Meghana S. Rayjade,Prajwal Y. Gosavi +5 more
TL;DR: The fast dissolving orally disintegrating film are the designed to dissolve upon contact with wet surface or fluids like saliva, within a few seconds as discussed by the authors , this is the most convenient dosage form for patients and also provides marketing advantages.
Journal ArticleDOI
Fast-Dissolving Protein Nanofibrous Membrane for Dual Drug Oral Delivery
Shan Miao,Zheng Chen,Jin Wang,Shanbo Ma,Long Li,Yuhan Chen,Fei Wang,Meiling Zheng,Xiaodi Guo,Bo Yune Song,Xiaopeng Shi +10 more
TL;DR: In this paper, the authors employed a sequential electrospinning approach to fabricate dual drug-loaded bilayered gelatin oral instant membranes for simultaneous loading and release of two drugs for fast dissolving delivery applications.
Journal ArticleDOI
Design, Development and Characterization of Flash release wafers containing Levocetrizine hydrochloride and Montelukast sodium
Sangeetha Subramanian,P. Mani +1 more
TL;DR: In this article , the authors developed and characterized flash release wafers containing Levocetrizine hydrochloride and Montelukast sodium using solvent casting method and showed that the formulation containing a lower concentration of polymer and a higher concentration of superdisintegrates showed a positive effect on disintegration time and drug release.
Journal ArticleDOI
Development and Evaluation of Fast Dissolving Liquisolid Haloperidol Tablets
TL;DR: In this article , fast dissolving tablets (FDT) of the anti-psychiatric drug, Haloperidol in liquisolid forms as a way to enhance its dissolution profile and antipsychiatric effect were designed.
References
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Journal ArticleDOI
Fast dissolving films made of maltodextrins.
TL;DR: This work aimed to study maltodextrins (MDX) with a low dextrose equivalent as film forming material and their application in the design of oral fast-dissolving films, and the MDX/plasticizer interactions were investigated by ATR-FTIR spectroscopy.
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Orally dissolving strips: A new approach to oral drug delivery system
TL;DR: As the drug is directly absorbed into systemic circulation, degradation in gastrointestinal tract and first pass effect can be avoided, these points make this formulation most popular and acceptable among pediatric and geriatric patients and patients with fear of choking.
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Formulation and evaluation of fast dissolving films for delivery of triclosan to the oral cavity.
TL;DR: Eugenol containing films improved the acceptability of TC-Poloxamer 407 films with respect to taste masking and mouth freshening without compromising the in vivo dissolution time.
A Short Review on "A Novel Approach in Oral Fast Dissolving Drug Delivery System and Their Patents"
Garima Garg,Pankaj Sharma +1 more
TL;DR: The oral thin-film technology is still in the beginning stages and has bright future ahead because it fulfils all the need of patients, and for future growth point of view the oral thin film sector is well-positioned.
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Orally disintegrating systems: innovations in formulation and technology.
TL;DR: This article attempts at discussing the patents relating to orally disintegrating systems with respect to the use of different formulation ingredients and technologies.