Orally disintegrating films: A modern expansion in drug delivery system.
Muhammad Irfan,Sumeira Rabel,Quratulain Bukhtar,Muhammad Imran Qadir,Farhat Jabeen,Ahmed Khan +5 more
TLDR
Orally disintegrating films have potential for business and market exploitation because of their myriad of benefits over orally disintegrating tablets and the market prospect of this innovative dosage form is also targeted.Abstract:
Over the past few decades, tendency toward innovative drug delivery systems has majorly increased attempts to ensure efficacy, safety and patient acceptability. As discovery and development of new chemical agents is a complex, expensive and time consuming process, so recent trends are shifting toward designing and developing innovative drug delivery systems for existing drugs. Out of those, drug delivery system being very eminent among pediatrics and geriatrics is orally disintegrating films (ODFs). These fast disintegrating films have superiority over fast disintegrating tablets as the latter are associated with the risks of choking and friability. This drug delivery system has numerous advantages over conventional fast disintegrating tablets as they can be used for dysphasic and schizophrenic patients and are taken without water due to their ability to disintegrate within a few seconds releasing medication in mouth. Various approaches are employed for formulating ODFs and among which solvent casting and spraying methods are frequently used. Generally, hydrophilic polymers along with other excipients are used for preparing ODFs which allow films to disintegrate quickly releasing incorporated active pharmaceutical ingredient (API) within seconds. Orally disintegrating films have potential for business and market exploitation because of their myriad of benefits over orally disintegrating tablets. This present review attempts to focus on benefits, composition, approaches for formulation and evaluation of ODFs. Additionally, the market prospect of this innovative dosage form is also targeted.read more
Citations
More filters
Journal ArticleDOI
Bioequivalence study of a new sildenafil 100 mg orodispersible film compared to the conventional film-coated 100 mg tablet administered to healthy male volunteers.
Milko Radicioni,Chiara Castiglioni,Andrea Giori,Irma Elisa Cupone,Valeria Frangione,Stefano Rovati +5 more
TL;DR: The results suggest that the new orodispersible film formulation can be used interchangeably with the conventional film-coated formulation and the bioequivalence test was fully satisfied for sildenafil and N-desmethyl-sildanafil in terms of rate and extent of bioavailability.
Journal ArticleDOI
Current Overview of Oral Thin Films.
TL;DR: This review examines oral thin films in all aspects from today's point of view and gives an idea about the growing market share in the world due to the increase in research fields and technological developments.
Journal ArticleDOI
Mucoadhesive Polymeric Films to Enhance Barbaloin Penetration Into Buccal Mucosa: a Novel Approach to Chemoprevention
TL;DR: Remarkable penetration enhancer properties of film were demonstrated by evidence of Barbaloin accumulation into buccal mucosa up to 10-fold higher than those obtained following administration of Aloin solution, as well as demonstrating that diffusion through the matrix is the main release mechanism.
Journal ArticleDOI
Isolation and characterization of natural polysaccharide from Cassia Obtustifolia seed mucilage as film forming material for drug delivery.
TL;DR: It is demonstrated that the Cassia obtustifolia seed mucilage had potential to use as film forming excipient with enhanced characteristics for drug delivery application.
Journal ArticleDOI
Key acceptability attributes of orodispersible films.
Mariagiovanna Scarpa,Amrit Paudel,Frank Kloprogge,Wen Kai Hsiao,Massimo Bresciani,Simon Gaisford,Mine Orlu +6 more
TL;DR: ODF stickiness and disintegration time should be evaluated at an early stage of the drug product design, and DMA and drop methods proved to be promising methodologies for the prediction of the end‐user acceptability.
References
More filters
Journal ArticleDOI
Fast dissolving films made of maltodextrins.
TL;DR: This work aimed to study maltodextrins (MDX) with a low dextrose equivalent as film forming material and their application in the design of oral fast-dissolving films, and the MDX/plasticizer interactions were investigated by ATR-FTIR spectroscopy.
Journal ArticleDOI
Orally dissolving strips: A new approach to oral drug delivery system
TL;DR: As the drug is directly absorbed into systemic circulation, degradation in gastrointestinal tract and first pass effect can be avoided, these points make this formulation most popular and acceptable among pediatric and geriatric patients and patients with fear of choking.
Journal ArticleDOI
Formulation and evaluation of fast dissolving films for delivery of triclosan to the oral cavity.
TL;DR: Eugenol containing films improved the acceptability of TC-Poloxamer 407 films with respect to taste masking and mouth freshening without compromising the in vivo dissolution time.
A Short Review on "A Novel Approach in Oral Fast Dissolving Drug Delivery System and Their Patents"
Garima Garg,Pankaj Sharma +1 more
TL;DR: The oral thin-film technology is still in the beginning stages and has bright future ahead because it fulfils all the need of patients, and for future growth point of view the oral thin film sector is well-positioned.
Journal ArticleDOI
Orally disintegrating systems: innovations in formulation and technology.
TL;DR: This article attempts at discussing the patents relating to orally disintegrating systems with respect to the use of different formulation ingredients and technologies.