Orally disintegrating films: A modern expansion in drug delivery system.
Muhammad Irfan,Sumeira Rabel,Quratulain Bukhtar,Muhammad Imran Qadir,Farhat Jabeen,Ahmed Khan +5 more
TLDR
Orally disintegrating films have potential for business and market exploitation because of their myriad of benefits over orally disintegrating tablets and the market prospect of this innovative dosage form is also targeted.Abstract:
Over the past few decades, tendency toward innovative drug delivery systems has majorly increased attempts to ensure efficacy, safety and patient acceptability. As discovery and development of new chemical agents is a complex, expensive and time consuming process, so recent trends are shifting toward designing and developing innovative drug delivery systems for existing drugs. Out of those, drug delivery system being very eminent among pediatrics and geriatrics is orally disintegrating films (ODFs). These fast disintegrating films have superiority over fast disintegrating tablets as the latter are associated with the risks of choking and friability. This drug delivery system has numerous advantages over conventional fast disintegrating tablets as they can be used for dysphasic and schizophrenic patients and are taken without water due to their ability to disintegrate within a few seconds releasing medication in mouth. Various approaches are employed for formulating ODFs and among which solvent casting and spraying methods are frequently used. Generally, hydrophilic polymers along with other excipients are used for preparing ODFs which allow films to disintegrate quickly releasing incorporated active pharmaceutical ingredient (API) within seconds. Orally disintegrating films have potential for business and market exploitation because of their myriad of benefits over orally disintegrating tablets. This present review attempts to focus on benefits, composition, approaches for formulation and evaluation of ODFs. Additionally, the market prospect of this innovative dosage form is also targeted.read more
Citations
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Thin films as an emerging platform for drug delivery
TL;DR: The aim of this review is to provide an overview of the critical factors affecting the formulation of thin films, including the physico-chemical properties of polymers and drugs, anatomical and physiological constraints, as well as the characterization methods and quality specifications to circumvent the difficulties associated with formulation design.
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Orodispersible films: Towards drug delivery in special populations.
Mariagiovanna Scarpa,Sven Stegemann,Wen Kai Hsiao,Heinz Pichler,Simon Gaisford,Massimo Bresciani,Amrit Paudel,Mine Orlu +7 more
TL;DR: The current strides of ODF technology and some of its unmet quality and manufacturing aspects are reviewed, which highlights opportunities and limitations of inkjet printed ODF as a population-specific drug delivery.
Journal ArticleDOI
Effect of plasticizers on the physico-mechanical properties of pullulan based pharmaceutical oral films.
TL;DR: The present study concluded that glycerol is suitable plasticizer compared to others for manufacturing pullulan based oral films.
Journal ArticleDOI
Advances in drug delivery systems: Work in progress still needed?
Flavia Laffleur,Valérie Keckeis +1 more
TL;DR: This work provides an insight of the novel approaches in drug delivery covering the critical comparison between traditional and novel “advanced-designed” systems.
Journal ArticleDOI
Personalisation of warfarin therapy using thermal ink-jet printing
Parameswara Rao Vuddanda,Mustafa Alomari,Cornelius C. Dodoo,Sarah J. Trenfield,Sitaram P. Velaga,Abdul Basit,Simon Gaisford +6 more
TL;DR: This study successfully formulated personalised warfarin ODFs using a modified TIJ printer, widening the range of applications for TIJ printing to formulate narrow therapeutic index drugs.
References
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Formulation of a Novel Tianeptine Sodium Orodispersible Film
TL;DR: Findings suggest that the fast orodispersible film containing tianeptine is likely to become one of choices for acute treatment of depression.
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In vitro and in vivo characteristics of prochlorperazine oral disintegrating film.
Nishimura Misao,Katsuhiko Matsuura,Tadao Tsukioka,Hirotaka Yamashita,Naoki Inagaki,Tadashi Sugiyama,Yoshinori Itoh +6 more
TL;DR: It is suggested that the present prochlorperazine-containing oral film is potentially useful to control emesis induced by anti-cancer agents or opioid analgesics in patients who limit the oral intake.
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Characterization of oral disintegrating film containing donepezil for Alzheimer disease.
TL;DR: ODF containing 7 mg of sucralose were more superior than saccharin and aspartame in terms of taste, aftertaste, mouthfeel and acceptance and was stable for at least 6 months when stored at 40°C and 75% relative humidity.
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Fluconazole Mucoadhesive Buccal Films: In Vitro/In Vivo Performance
TL;DR: Determination of the amount of drug released in saliva after application of the selected fluconazole films confirmed the ability of the film to deliver the drug over a period of approximately 300 minutes and to reduce side effects and possibility of drug interaction encountered during systemic therapy of flu Conazole, which would be beneficial in the case of oral candidiasis.
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Hydrodynamic investigation of USP dissolution test apparatus II
TL;DR: In this work, laser-Doppler velocimetry (LDV) and computational fluid dynamics (CFD) were used to experimentally map and computationally predict the velocity distribution inside a standard USP Apparatus II under the typical operating conditions mandated by the dissolution test procedure.