Orally disintegrating films: A modern expansion in drug delivery system.
Muhammad Irfan,Sumeira Rabel,Quratulain Bukhtar,Muhammad Imran Qadir,Farhat Jabeen,Ahmed Khan +5 more
TLDR
Orally disintegrating films have potential for business and market exploitation because of their myriad of benefits over orally disintegrating tablets and the market prospect of this innovative dosage form is also targeted.Abstract:
Over the past few decades, tendency toward innovative drug delivery systems has majorly increased attempts to ensure efficacy, safety and patient acceptability. As discovery and development of new chemical agents is a complex, expensive and time consuming process, so recent trends are shifting toward designing and developing innovative drug delivery systems for existing drugs. Out of those, drug delivery system being very eminent among pediatrics and geriatrics is orally disintegrating films (ODFs). These fast disintegrating films have superiority over fast disintegrating tablets as the latter are associated with the risks of choking and friability. This drug delivery system has numerous advantages over conventional fast disintegrating tablets as they can be used for dysphasic and schizophrenic patients and are taken without water due to their ability to disintegrate within a few seconds releasing medication in mouth. Various approaches are employed for formulating ODFs and among which solvent casting and spraying methods are frequently used. Generally, hydrophilic polymers along with other excipients are used for preparing ODFs which allow films to disintegrate quickly releasing incorporated active pharmaceutical ingredient (API) within seconds. Orally disintegrating films have potential for business and market exploitation because of their myriad of benefits over orally disintegrating tablets. This present review attempts to focus on benefits, composition, approaches for formulation and evaluation of ODFs. Additionally, the market prospect of this innovative dosage form is also targeted.read more
Citations
More filters
Journal ArticleDOI
Thin films as an emerging platform for drug delivery
TL;DR: The aim of this review is to provide an overview of the critical factors affecting the formulation of thin films, including the physico-chemical properties of polymers and drugs, anatomical and physiological constraints, as well as the characterization methods and quality specifications to circumvent the difficulties associated with formulation design.
Journal ArticleDOI
Orodispersible films: Towards drug delivery in special populations.
Mariagiovanna Scarpa,Sven Stegemann,Wen Kai Hsiao,Heinz Pichler,Simon Gaisford,Massimo Bresciani,Amrit Paudel,Mine Orlu +7 more
TL;DR: The current strides of ODF technology and some of its unmet quality and manufacturing aspects are reviewed, which highlights opportunities and limitations of inkjet printed ODF as a population-specific drug delivery.
Journal ArticleDOI
Effect of plasticizers on the physico-mechanical properties of pullulan based pharmaceutical oral films.
TL;DR: The present study concluded that glycerol is suitable plasticizer compared to others for manufacturing pullulan based oral films.
Journal ArticleDOI
Advances in drug delivery systems: Work in progress still needed?
Flavia Laffleur,Valérie Keckeis +1 more
TL;DR: This work provides an insight of the novel approaches in drug delivery covering the critical comparison between traditional and novel “advanced-designed” systems.
Journal ArticleDOI
Personalisation of warfarin therapy using thermal ink-jet printing
Parameswara Rao Vuddanda,Mustafa Alomari,Cornelius C. Dodoo,Sarah J. Trenfield,Sitaram P. Velaga,Abdul Basit,Simon Gaisford +6 more
TL;DR: This study successfully formulated personalised warfarin ODFs using a modified TIJ printer, widening the range of applications for TIJ printing to formulate narrow therapeutic index drugs.
References
More filters
Journal ArticleDOI
Dissofilm: a novel approach for delivery of phenobarbital; design and characterization.
TL;DR: An attempt to develop and evaluate mouth-dissolving film of phenobarbital for quick effect in treatment of epilepsy occurring in pediatric population and in vivo studies in hamster reports effective and safe use of formulation in animals.
Journal ArticleDOI
Development and characterization of pharmacokinetic parameters of fast-dissolving films containing levocetirizine.
Dhagla R. Choudhary,Vishnu A. Patel,Usmangani K. Chhalotiya,Harsha V. Patel,Aliasgar J. Kundawala +4 more
TL;DR: The results suggest that the present levocetirizine containing fast-dissolving film is likely to become one of the choices to treat different allergic conditions.
Journal ArticleDOI
Formulation development and evaluation of mouth dissolving film of domperidone
TL;DR: Five formulae were prepared and were evaluated for their in vitro dissolution characteristics, in vitro disintegration time, and physico-mechanical properties that are suitable for mouth dissolving films and the promising film showed the greatest drug dissolution.
Formulation and evaluation of fast dissolving film of an antihypertensive drug
TL;DR: In this paper, a fast dissolving film of Losartan potassium for the treatment of hypertension, by using polymers such as PolyVinylAlcohol (PVA) and Maltodextrin (MD) in different concentrations.
Journal ArticleDOI
Quick dissolving films of nebivolol hydrochloride: formulation and optimization by a simplex lattice design
TL;DR: In this paper, a quick dissolving film of nebivolol hydrochloride applying simple lattice experimental design using three hetero polymers hydroxypropyl methylcellulose, pullulan and polyvinyl pyrrolidone.