Orally disintegrating films: A modern expansion in drug delivery system.
Muhammad Irfan,Sumeira Rabel,Quratulain Bukhtar,Muhammad Imran Qadir,Farhat Jabeen,Ahmed Khan +5 more
TLDR
Orally disintegrating films have potential for business and market exploitation because of their myriad of benefits over orally disintegrating tablets and the market prospect of this innovative dosage form is also targeted.Abstract:
Over the past few decades, tendency toward innovative drug delivery systems has majorly increased attempts to ensure efficacy, safety and patient acceptability. As discovery and development of new chemical agents is a complex, expensive and time consuming process, so recent trends are shifting toward designing and developing innovative drug delivery systems for existing drugs. Out of those, drug delivery system being very eminent among pediatrics and geriatrics is orally disintegrating films (ODFs). These fast disintegrating films have superiority over fast disintegrating tablets as the latter are associated with the risks of choking and friability. This drug delivery system has numerous advantages over conventional fast disintegrating tablets as they can be used for dysphasic and schizophrenic patients and are taken without water due to their ability to disintegrate within a few seconds releasing medication in mouth. Various approaches are employed for formulating ODFs and among which solvent casting and spraying methods are frequently used. Generally, hydrophilic polymers along with other excipients are used for preparing ODFs which allow films to disintegrate quickly releasing incorporated active pharmaceutical ingredient (API) within seconds. Orally disintegrating films have potential for business and market exploitation because of their myriad of benefits over orally disintegrating tablets. This present review attempts to focus on benefits, composition, approaches for formulation and evaluation of ODFs. Additionally, the market prospect of this innovative dosage form is also targeted.read more
Citations
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New formulation and approach for mucoadhesive buccal film of rizatriptan benzoate
Sahar Salehi,Soheil Boddohi +1 more
TL;DR: The results suggest that RB-loaded mucoadhesive buccal films could be a potential candidate to achieve optimum drug release for effective treatment of migraine.
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Production of Electrospun Fast-Dissolving Drug Delivery Systems with Therapeutic Eutectic Systems Encapsulated in Gelatin.
Francisca Mano,Marta Martins,Isabel de Sá-Nogueira,Susana Barreiros,João Borges,Rui L. Reis,Ana Rita C. Duarte,Alexandre Paiva +7 more
TL;DR: With no cytotoxicity effect, and showing a fast-dissolving release profile in PBS, the gelatin fibers with encapsulated THEDES seem to have promising applications in the development of new drug delivery systems.
Journal ArticleDOI
Gelatin/starch orally disintegrating films as a promising system for vitamin C delivery
Vitor Augusto dos Santos Garcia,Josiane Gonçalves Borges,Vinicius Borges Vieira Maciel,Mônica Roberta Mazalli,Judite Lapa-Guimarães,Fernanda Maria Vanin,Rosemary Aparecida de Carvalho +6 more
TL;DR: In this article, a spray-drying method from camu-camu powder was used to produce gelatin and starch ODFs as vehicles of vitamin C obtained via a spray drying method.
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Development and Characterization of Chitosan Microparticles-in-Films for Buccal Delivery of Bioactive Peptides
TL;DR: The chitosan mucoadhesive films loaded with peptide–chitOSan microparticles resulted in an innovative approach to perform administration across the buccal mucosa, because these films present a larger surface area, leading to the rapid disintegration and release of the antihypertensive peptide under controlled conditions in thebuccal cavity, thus promoting bioavailability.
Journal ArticleDOI
Orodispersible films based on blends of trehalose and pullulan for protein delivery
Yu Tian,J. Carolina Visser,Job S. Klever,Herman J. Woerdenbag,Henderik W. Frijlink,Wouter L. J. Hinrichs +5 more
TL;DR: Trehalose/pullulan‐based ODFs are from a technical point promising for possible protein delivery via the oral cavity and freeze-drying appeared to be favorable over air‐drying for process stability while the reverse was found for storage stability.
References
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Fast dissolving films made of maltodextrins.
TL;DR: This work aimed to study maltodextrins (MDX) with a low dextrose equivalent as film forming material and their application in the design of oral fast-dissolving films, and the MDX/plasticizer interactions were investigated by ATR-FTIR spectroscopy.
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Orally dissolving strips: A new approach to oral drug delivery system
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Formulation and evaluation of fast dissolving films for delivery of triclosan to the oral cavity.
TL;DR: Eugenol containing films improved the acceptability of TC-Poloxamer 407 films with respect to taste masking and mouth freshening without compromising the in vivo dissolution time.
A Short Review on "A Novel Approach in Oral Fast Dissolving Drug Delivery System and Their Patents"
Garima Garg,Pankaj Sharma +1 more
TL;DR: The oral thin-film technology is still in the beginning stages and has bright future ahead because it fulfils all the need of patients, and for future growth point of view the oral thin film sector is well-positioned.
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Orally disintegrating systems: innovations in formulation and technology.
TL;DR: This article attempts at discussing the patents relating to orally disintegrating systems with respect to the use of different formulation ingredients and technologies.