Journal ArticleDOI
Physiological functions of Vitamin D in adipose tissue
TLDR
Several functions of unliganded nVDR were discovered by studying human samples from patients having hereditary vitamin D resistant rickets, transgenic mice overexpressing the VDR and VDR knockout mice, and in vitro, vitamin D stimulates lipogenesis and inhibits lipolysis by interacting with mVDR.About:
This article is published in The Journal of Steroid Biochemistry and Molecular Biology.The article was published on 2017-01-01. It has received 225 citations till now. The article focuses on the topics: Calcitriol receptor & vitamin D deficiency.read more
Citations
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Journal ArticleDOI
Obesity and dyslipidemia.
Jelena Vekic,Aleksandra Zeljkovic,Aleksandra Stefanović,Zorana Jelic-Ivanovic,Vesna Spasojevic-Kalimanovska +4 more
TL;DR: This review will address the main characteristics of dyslipidemia and mechanisms that induce its development in obesity, in particular proprotein convertase subtilisin/kexin type 9 (PCSK9), as the key molecule that regulates metabolism of low-density lipoproteins (LDL), and sphingosine-1-phosphate (S1P), as one of the most important mediators of high-densitylipoprotein (HDL) particles function.
Journal ArticleDOI
Vitamin D deficiency and diabetes.
TL;DR: The role of Vitamin D in maintaining the normal release of insulin by the pancreatic beta cells (β-cells) is summarized, which contributes to both the initial insulin resistance and the subsequent onset of diabetes caused by β-cell death.
Journal ArticleDOI
Analysis of Association between Vitamin D Deficiency and Insulin Resistance.
TL;DR: The results of basic and clinical research support beneficial action of vitamin D in the reduction of insulin resistance and related pathologies.
Journal ArticleDOI
Low vitamin D status and obesity: Role of nutritionist
Silvia Savastano,Luigi Barrea,Maria Cristina Savanelli,Francesca Nappi,Carolina Di Somma,Francesco Orio,Annamaria Colao +6 more
TL;DR: The aim of the present review was to examine the current evidence linking low vitamin D status and obesity in relation to the role of the nutritionist and to accurately address the aspects influencing the lowitamin D status in obesity and the vitamin D supplementation in obese individuals.
Journal ArticleDOI
Effect of Vitamin D3 Supplements on Development of Advanced Cancer: A Secondary Analysis of the VITAL Randomized Clinical Trial.
Paulette D. Chandler,Wendy Y. Chen,Wendy Y. Chen,Oluremi N Ajala,Aditi Hazra,Nancy R. Cook,Vadim Bubes,I-Min Lee,Edward Giovannucci,Edward Giovannucci,Walter C. Willett,Walter C. Willett,Julie E. Buring,Julie E. Buring,JoAnn E. Manson,JoAnn E. Manson +15 more
TL;DR: It is suggested that vitamin D3 may reduce the risk of developing advanced cancer among adults without a diagnosis of cancer at baseline; this protective effect is apparent for those who have normal but not elevated body mass index.
References
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Journal ArticleDOI
Central nervous system control of food intake
TL;DR: A model is described that delineates the roles of individual hormonal and neuropeptide signalling pathways in the control of food intake and the means by which obesity can arise from inherited or acquired defects in their function.
Journal ArticleDOI
Identification and Importance of Brown Adipose Tissue in Adult Humans
AM Cypess,Sanaz Lehman,Gethin Williams,Ilan Tal,Dean Rodman,Allison B. Goldfine,FC Kuo,Edwin L. Palmer,Yu-Hua Tseng,Alessandro Doria,Gerald M. Kolodny,C R Kahn +11 more
TL;DR: Defined regions of functionally active brown adipose tissue are present in adult humans, are more frequent in women than in men, and may be quantified noninvasively with the use of (18)F-FDG PET-CT.
Journal ArticleDOI
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
TL;DR: A novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related protein of 30 kDa), that is made exclusively in adipocytes and whose mRNA is induced over 100-fold during adipocyte differentiation is described.
Journal ArticleDOI
Decreased bioavailability of vitamin D in obesity
TL;DR: Obese subjects had significantly lower basal 25-hydroxyvitamin D concentrations and higher parathyroid hormone concentrations than did age-matched control subjects and the incremental increase in vitamin D(3) was 57% lower in obese than in nonobese subjects.
Journal ArticleDOI
Macrophages, Inflammation, and Insulin Resistance
TL;DR: Strategies focused on inhibiting the inflammation/insulin resistance axis that otherwise preserve essential innate immune functions may hold promise for therapeutic intervention.
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