Phytochemicals containing biologically active polyphenols as an effective agent against Covid-19-inducing coronavirus
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TLDR
The known pharmacophore structures of bioactive substances can be useful in the elaboration of new anti-Covid-19 formulations and the benefit of using preparations containing phytochemicals is their high safety for patients and no side effects.About:
This article is published in Journal of Functional Foods.The article was published on 2020-10-01 and is currently open access. It has received 116 citations till now. The article focuses on the topics: Coronavirus.read more
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Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma.
Duraisamy Kempuraj,Duraisamy Kempuraj,Ramasamy Thangavel,Ramasamy Thangavel,Deepak D. Kempuraj,Mohammad Ejaz Ahmed,Mohammad Ejaz Ahmed,Govindhasamy Pushpavathi Selvakumar,Govindhasamy Pushpavathi Selvakumar,Sudhanshu P. Raikwar,Sudhanshu P. Raikwar,Smita Zaheer,Shankar S. Iyer,Shankar S. Iyer,Raghav Govindarajan,Premkumar Nattanmai Chandrasekaran,Asgar Zaheer,Asgar Zaheer +17 more
TL;DR: Luteolin can improve cognitive decline and enhance neuroprotection in neurodegenerative diseases, TBI, and stroke, and recent reports suggest that luteolin suppresses systemic and neuroinflammatory responses in Coronavirus disease 2019.
Journal ArticleDOI
Quercetin: Antiviral Significance and Possible COVID-19 Integrative Considerations
TL;DR: The antiviral significance of quercetin is summarized and a possible strategy for the effective utilization of natural polyphenols in the authors' daily diet for the prevention of viral infection is proposed.
Journal ArticleDOI
Screening of phytochemicals as potent inhibitor of 3-chymotrypsin and papain-like proteases of SARS-CoV2: an in silico approach to combat COVID-19.
TL;DR: Amentoflavone and Gallocatechin gallate may be potential inhibitors of 3CLpro and PLpro proteins and effective drug candidates for SARS-CoV2, but the findings need to be supported by in vivo studies to establish the exact mode of action.
Journal ArticleDOI
Polyphenols and their potential role to fight viral diseases: An overview.
María Fernanda Montenegro-Landívar,Paulina Tapia-Quirós,Xanel Vecino,M. Reig,César Valderrama,Mercè Granados,José Luis Cortina,Javier Saurina +7 more
TL;DR: In this paper, the potential antiviral properties of some polyphenols and their action mechanism against various types of viruses such as coronaviruses, influenza, herpes simplex, dengue fever, and rotavirus, among others.
References
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Nano based drug delivery systems: recent developments and future prospects
Jayanta Kumar Patra,Gitishree Das,Leonardo Fernandes Fraceto,Leonardo Fernandes Fraceto,Estefania Vangelie Ramos Campos,Estefania Vangelie Ramos Campos,Maria del Pilar Rodriguez-Torres,Laura Susana Acosta-Torres,Luis A. Diaz-Torres,Renato Grillo,Mallappa Kumara Swamy,Shivesh Sharma,Solomon Habtemariam,Han-Seung Shin +13 more
TL;DR: An updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs and selective diagnosis through disease marker molecules is presented.
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Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plants.
Muhammad Tahir ul Qamar,Muhammad Tahir ul Qamar,Safar M. Alqahtani,Mubarak A. Alamri,Ling-Ling Chen,Ling-Ling Chen +5 more
TL;DR: Analysis of the 3CLpro sequence, constructed its 3D homology model, and screened it against a medicinal plant library containing 32,297 potential anti-viral phytochemicals/traditional Chinese medicinal compounds revealed that the top nine hits might serve as potentialAnti- SARS-CoV-2 lead molecules for further optimisation and drug development process to combat COVID-19.
Journal ArticleDOI
Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2.
Zhixin Liu,Zhixin Liu,Xiao Xiao,Xiuli Wei,Jian Li,Jing Yang,Huabing Tan,Jianyong Zhu,Qiwei Zhang,Qiwei Zhang,Jianguo Wu,Jianguo Wu,Long Liu +12 more
TL;DR: Systematic comparison and analysis used to predict the interaction between the receptor‐binding domain (RBD) of coronavirus spike protein and the host receptor, angiotensin‐converting enzyme 2 (ACE2) indicated that turtles may act as the potential intermediate hosts transmitting SARS‐CoV‐2 to humans.
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Inhibition of SARS-CoV 3CL protease by flavonoids.
TL;DR: Herbacetin, rhoifolin and pectolinarin were found to efficiently block the enzymatic activity of SARS-CoV 3CLpro and are suggested to be templates to design functionally improved inhibitors.
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