Journal ArticleDOI
Picornavirus and enterovirus diversity with associated human diseases
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TLDR
The Enterovirus genus is a prototype example of the Picornaviridae heterogeneity at both genetic and phenotypic levels and better characterization of these ubiquitous human pathogens may help to develop vaccines or antiviral treatments and to monitor the emergence of new strains.Citations
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Journal ArticleDOI
Salivirus in children with diarrhoea, western India.
TL;DR: Salivirus (SalV) was found to be the sole aetiological agent in six cases of paediatric diarrhoea.
Journal ArticleDOI
Upsurge of Enterovirus D68 and Circulation of the New Subclade D3 and Subclade B3 in Beijing, China, 2016.
Lingyu Shen,Cheng Gong,Zichun Xiang,Tie-gang Zhang,Maozhong Li,Aihua Li,Ming Luo,Fang Huang,Fang Huang +8 more
TL;DR: Data suggest an upsurge of EV-D68 occurred in Beijing in 2016, the new subclade D3 emerged in 2016 and co-circulated with sub clade B3 between 2016 and 2017, and the phylogenetic analysis suggested 15 subcladed D3 strains and 27 subclades B3 strains were circulated in China from 2016 to 2017.
Book ChapterDOI
Drugging the Phosphoinositide 3-Kinase (PI3K) and Phosphatidylinositol 4-Kinase (PI4K) Family of Enzymes for Treatment of Cancer, Immune Disorders, and Viral/Parasitic Infections.
Jacob A. McPhail,John E. Burke +1 more
TL;DR: The lipid kinases that generate the lipid signalling phosphoinositides have been established as fundamental signalling enzymes that control numerous aspects of how cells respond to their extracellular environment, and the development of targeted isoform selective inhibitors for these enzymes are of paramount importance.
Journal ArticleDOI
Molecular characterization and epidemiological aspects of non-polio enteroviruses isolated from acute flaccid paralysis in Brazil: a historical series (2005–2017)
Ivanildo P. Sousa,Maria de Lourdes Aguiar Oliveira,Fernanda M. Burlandy,Raiana Scerni Machado,Silas S. Oliveira,Fernando Neto Tavares,Francisco Gomes-Neto,Eliane Veiga da Costa,Edson E. da Silva +8 more
TL;DR: This study provides extensive information on enterovirus diversity associated with AFP, reinforcing the need of tailoring current surveillance strategies to timely monitor emergence/re-emergence of NPEVs.
Journal ArticleDOI
Data fitting approach more critical than exposure scenarios and treatment of censored data for quantitative microbial risk assessment.
TL;DR: The findings suggest that in most cases the use of the half-SLOD approach is appropriate for QMRA modeling, which captured the uniqueness of each sample since they account for the history of the sample including the concentration procedure and the detection method used.
References
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Book
Virus taxonomy: classification and nomenclature of viruses. Seventh report of the International Committee on Taxonomy of Viruses.
TL;DR: This report builds on the accumulated taxonomic construction of the eight previous reports dating back to 1971 and records the proceedings of the Committee since publication of the last report in 2005.
Journal ArticleDOI
Community study of role of viral infections in exacerbations of asthma in 9-11 year old children.
Sebastian L. Johnston,Philip Pattemore,G. Sanderson,Sandra Smith,F Lampe,Lynn Josephs,P. Symington,S. O'Toole,S. H. Myint,D. A. J. Tyrrell +9 more
TL;DR: This study supports the hypothesis that upper respiratory viral infections are associated with 80-85% of asthma exacerbations in school age children.
Journal ArticleDOI
Mutation rates among RNA viruses
John W. Drake,John J. Holland +1 more
TL;DR: This work describes a simple relation between ribovirus mutation frequencies and mutation rates, applies it to the best (albeit far from satisfactory) available data, and observes a central value for the mutation rate per genome per replication of micro(g) approximately 0.76.
Journal ArticleDOI
Virology, epidemiology, pathogenesis, and control of enterovirus 71.
Tom Solomon,Tom Solomon,Penny Lewthwaite,David Perera,Mary Jane Cardosa,Peter McMinn,Mong How Ooi,Mong How Ooi +7 more
TL;DR: Enterovirus 71 is a major public health issue across the Asia-Pacific region and beyond, with new outbreaks occurring across Asia in regular cycles, and virus gene subgroups seem to differ in clinical epidemiological properties.