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Picornavirus and enterovirus diversity with associated human diseases
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TLDR
The Enterovirus genus is a prototype example of the Picornaviridae heterogeneity at both genetic and phenotypic levels and better characterization of these ubiquitous human pathogens may help to develop vaccines or antiviral treatments and to monitor the emergence of new strains.Citations
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Antiviral Natural Products and Herbal Medicines
TL;DR: In this mini-review, a summary of the antiviral effects reported for several natural products and herbal medicines is summarized.
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Neurotropic virus infections as the cause of immediate and delayed neuropathology.
Martin Ludlow,Jeroen Kortekaas,Christiane Herden,Bernd Hoffmann,Dennis Tappe,Corinna Trebst,Diane E. Griffin,Hannah Brindle,Tom Solomon,Alan S. Brown,Debby van Riel,Katja C. Wolthers,Dasja Pajkrt,Peter Wohlsein,Byron E. E. Martina,Wolfgang Baumgärtner,Georges M. G. M. Verjans,Georges M. G. M. Verjans,Albert D. M. E. Osterhaus,Albert D. M. E. Osterhaus +19 more
TL;DR: Mechanisms that govern neuropathogenesis and immunopathogenesis of viral infections are highlighted, using examples of well-studied virus infections that are associated with these alterations in different populations throughout the world.
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Hand, foot and mouth disease (HFMD): emerging epidemiology and the need for a vaccine strategy
TL;DR: The development of a globally representative multivalent HFMD vaccine could be the best strategy to protect against other major emerging etiologies of HFMD such as CV-A16,CV-A6 and CV- a10.
Journal ArticleDOI
Enterovirus and parechovirus infection in children: a brief overview
TL;DR: This review is an overview of what is known from enterovirus and parechovirus infection in children and contains information about the epidemiology, pathogenesis, clinical presentation, diagnosis, treatment, and prognosis of enterov virus and paredchov virus infection inChildren.
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Probiotics in respiratory virus infections
TL;DR: More randomized, double-blind, and placebo-controlled trials in different age populations investigating probiotic dose response, comparing probiotic strains/genera, and elucidating the antiviral effect mechanisms are necessary to provide insights on the possible antiviral mechanisms of probiotics.
References
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Journal ArticleDOI
A novel group of rhinoviruses is associated with asthma hospitalizations
E. Kathryn Miller,Kathryn M. Edwards,Geoffrey A. Weinberg,Marika K. Iwane,Marie R. Griffin,Caroline B. Hall,Yuwei Zhu,Peter G. Szilagyi,Laura-Lee Morin,Luke Heil,Xiaoyan Lu,John V. Williams +11 more
TL;DR: Overall, HRVCs were detected in 7% of children hospitalized for fever or respiratory conditions and constituted almost half of all rhinovirus-associated hospitalizations, suggesting that this novel group causes a substantial burden of pediatric disease.
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Proposals for the classification of human rhinovirus species C into genotypically assigned types.
Peter Simmonds,Chloe McIntyre,Carita Savolainen-Kopra,Caroline Tapparel,Ian M. Mackay,Tapani Hovi +5 more
TL;DR: A threshold of 13% divergence for VP1 nucleotide sequences for type assignment is proposed, a level that classifies the current dataset of 86 HRV-C VP1 sequences into a total of 33 types, and proposes a subsidiary classification of variants showing > 10% divergence in VP4/VP2, but lackingVP1 sequences, to 28 provisionally assigned types.
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The ABCs of Rhinoviruses, Wheezing, and Asthma
TL;DR: The close relationship between HRV infections and asthma suggests that antiviral treatments could have a major impact on the morbidity associated with this chronic respiratory disease.
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The complete nucleotide sequence of a common cold virus: human rhinovlrus 14
TL;DR: Comparison of the nucleotide sequence and the predicted amino acid sequence with those of the polioviruses reveals a surprising degree of homology which may allow recognition of regions of antigenic importance and prediction of the virus polyprotein cleavage sites.
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Genetic clustering of all 102 human rhinovirus prototype strains: serotype 87 is close to human enterovirus 70
TL;DR: The genetic relationships of HRV prototype strains and the possibility of using genetic identification of a given HRV field strain were studied, and larger numbers of field isolates of known serotype need to be characterized, possibly also in the VP1 region, to evaluate the feasibility of genetic typing of HRVs.