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Picornavirus and enterovirus diversity with associated human diseases
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TLDR
The Enterovirus genus is a prototype example of the Picornaviridae heterogeneity at both genetic and phenotypic levels and better characterization of these ubiquitous human pathogens may help to develop vaccines or antiviral treatments and to monitor the emergence of new strains.Citations
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Whole Genome Sequencing of Enterovirus species C Isolates by High-Throughput Sequencing: Development of Generic Primers
Maël Bessaud,Maël Bessaud,Serge Alain Sadeuh-Mba,Marie-Line Joffret,Marie-Line Joffret,Richter Razafindratsimandresy,Patsy M. Polston,Patsy M. Polston,Romain Volle,Romain Volle,Mala Rakoto-Andrianarivelo,Bruno Blondel,Bruno Blondel,Richard Njouom,Francis Delpeyroux,Francis Delpeyroux +15 more
TL;DR: A simple method was developed to quickly sequence the entire genome of EV-C isolates, decreasing the workload compared to classical Sanger-based techniques, and will serve as a precious tool for sequencing large panels ofEV-Cs isolated in cell cultures during environmental surveillance or from patients, including vaccine-derived polioviruses.
Journal ArticleDOI
The dark side of the gut: Virome-host interactions in intestinal homeostasis and disease.
TL;DR: In this article, the authors provide an overview of the enteric virome composition and summarize recent findings about how enteric viruses are sensed by and in turn modulate host immune responses during homeostasis and disease.
Journal ArticleDOI
Synthesis and antiviral effect of novel fluoxetine analogues as enterovirus 2C inhibitors
Roberto Manganaro,Birgit Zonsics,Lisa Bauer,Moira Lorenzo Lopez,Tim Donselaar,Marleen Zwaagstra,Fabiana Saporito,Salvatore Ferla,Jeroen R.P.M. Strating,Bruno Coutard,Daniel L. Hurdiss,Frank J. M. van Kuppeveld,Andrea Brancale +12 more
TL;DR: The synthesis and the antiviral effect of a series of fluoxetine analogues are reported and a preliminary insight is offered into the structure-activity relationship of its chemical scaffold and the importance of the chiral configuration is confirmed.
Journal ArticleDOI
Cerebrospinal fluid features in adults with enteroviral nervous system infection
Jonas Ahlbrecht,Lilly Katrin Hillebrand,Philipp Schwenkenbecher,Tina Ganzenmueller,Albert Heim,Ulrich Wurster,Martin Stangel,Kurt-Wolfram Sühs,Thomas Skripuletz +8 more
TL;DR: The absence of CSF pleocytosis, isolated cranial nerve involvement, and only infrequent general signs of infection may impede the diagnosis of enteroviral nervous system infections.
Journal ArticleDOI
Identification and Phylogenetic Characterization of Human Enteroviruses Isolated from Cases of Aseptic Meningitis in Brazil, 2013–2017
Emanuelle Ramalho,Emanuelle Ramalho,Ivanildo P. Sousa,Fernanda M. Burlandy,Eliane Veiga da Costa,Amanda Dias,Roseane Serrano,Maria Cristina Ferreira de Oliveira,Renato Matos Lopes,Maria do Carmo Debur,Marion Burger,Irina Nastassja Riediger,Maria de Lourdes Aguiar Oliveira,Osvaldo J. M. Nascimento,Edson E. da Silva +14 more
TL;DR: The results have provided valuable information about the enteroviral etiology of the aseptic meningitis cases in Brazil pointing to the importance of enterovirus surveillance in neurological diseases.
References
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Book
Virus taxonomy: classification and nomenclature of viruses. Seventh report of the International Committee on Taxonomy of Viruses.
TL;DR: This report builds on the accumulated taxonomic construction of the eight previous reports dating back to 1971 and records the proceedings of the Committee since publication of the last report in 2005.
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Community study of role of viral infections in exacerbations of asthma in 9-11 year old children.
Sebastian L. Johnston,Philip Pattemore,G. Sanderson,Sandra Smith,F Lampe,Lynn Josephs,P. Symington,S. O'Toole,S. H. Myint,D. A. J. Tyrrell +9 more
TL;DR: This study supports the hypothesis that upper respiratory viral infections are associated with 80-85% of asthma exacerbations in school age children.
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Mutation rates among RNA viruses
John W. Drake,John J. Holland +1 more
TL;DR: This work describes a simple relation between ribovirus mutation frequencies and mutation rates, applies it to the best (albeit far from satisfactory) available data, and observes a central value for the mutation rate per genome per replication of micro(g) approximately 0.76.
Journal ArticleDOI
Virology, epidemiology, pathogenesis, and control of enterovirus 71.
Tom Solomon,Tom Solomon,Penny Lewthwaite,David Perera,Mary Jane Cardosa,Peter McMinn,Mong How Ooi,Mong How Ooi +7 more
TL;DR: Enterovirus 71 is a major public health issue across the Asia-Pacific region and beyond, with new outbreaks occurring across Asia in regular cycles, and virus gene subgroups seem to differ in clinical epidemiological properties.