Journal ArticleDOI
Picornavirus and enterovirus diversity with associated human diseases
Reads0
Chats0
TLDR
The Enterovirus genus is a prototype example of the Picornaviridae heterogeneity at both genetic and phenotypic levels and better characterization of these ubiquitous human pathogens may help to develop vaccines or antiviral treatments and to monitor the emergence of new strains.Citations
More filters
Journal ArticleDOI
Molecular detection of enteric viruses in the stool samples of children without diarrhea in Bangladesh
Shoko Okitsu,Shoko Okitsu,Pattara Khamrin,Sayaka Takanashi,Aksara Thongprachum,Sheikh Ariful Hoque,Haruko Takeuchi,Alfazal Khan,S. M. Tafsir Hasan,Tsutomu Iwata,Hiroyuki Shimizu,Masamine Jimba,Satoshi Hayakawa,Niwat Maneekarn,Hiroshi Ushijima,Hiroshi Ushijima +15 more
TL;DR: Phylogenetic analysis showed that diverse HCoSV species and genotypes were circulating in Bangladesh, and four strains of species A are proposed to be new genotypes.
Journal ArticleDOI
Extracellular Vesicles in Virus Infection and Pathogenesis
Ryan P. McNamara,Dirk P. Dittmer +1 more
TL;DR: How EV can be used as potential biomarkers for chronic, persistent, or latent virus infections is explored and the recent advances in this field are covered.
Journal ArticleDOI
Fluoxetine can inhibit coxsackievirus-B4 E2 in vitro and in vivo.
TL;DR: In conclusion FLX can inhibit CV-B4 in vitro and in vivo in mouse systems, and additional studies are needed to investigate further the potential value of FLX to combat CV-b4 infections and to treat CV- B4-induced diseases.
Journal ArticleDOI
Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells.
Niina Lietzen,Karoliina Hirvonen,Anni Honkimaa,Tanja Buchacher,Jutta E. Laiho,Sami Oikarinen,Magdalena A. Mazur,Malin Flodström-Tullberg,Eric Dufour,Amir-Babak Sioofy-Khojine,Heikki Hyöty,Riitta Lahesmaa +11 more
TL;DR: This work established persistent CVB infections in a human pancreatic ductal-like cell line PANC-1 using two distinct CVB1 strains and profiled infection-induced changes in cellular protein expression and secretion using mass spectrometry-based proteomics.
Journal ArticleDOI
Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP)
Lisa Bauer,Salvatore Ferla,Sarah A. Head,Shridhar Bhat,Kalyan Kumar Pasunooti,Wei Shi,Lucian Albulescu,Jun O. Liu,Andrea Brancale,Frank J. M. van Kuppeveld,Jeroen R.P.M. Strating +10 more
TL;DR: The data show that several pharmacological activities of ITZ can be uncoupled, which is a critical step in the development of ITz‐based antiviral compounds with greater specificity and reduced off‐target effects.
References
More filters
Book
Virus taxonomy: classification and nomenclature of viruses. Seventh report of the International Committee on Taxonomy of Viruses.
TL;DR: This report builds on the accumulated taxonomic construction of the eight previous reports dating back to 1971 and records the proceedings of the Committee since publication of the last report in 2005.
Journal ArticleDOI
Community study of role of viral infections in exacerbations of asthma in 9-11 year old children.
Sebastian L. Johnston,Philip Pattemore,G. Sanderson,Sandra Smith,F Lampe,Lynn Josephs,P. Symington,S. O'Toole,S. H. Myint,D. A. J. Tyrrell +9 more
TL;DR: This study supports the hypothesis that upper respiratory viral infections are associated with 80-85% of asthma exacerbations in school age children.
Journal ArticleDOI
Mutation rates among RNA viruses
John W. Drake,John J. Holland +1 more
TL;DR: This work describes a simple relation between ribovirus mutation frequencies and mutation rates, applies it to the best (albeit far from satisfactory) available data, and observes a central value for the mutation rate per genome per replication of micro(g) approximately 0.76.
Journal ArticleDOI
Virology, epidemiology, pathogenesis, and control of enterovirus 71.
Tom Solomon,Tom Solomon,Penny Lewthwaite,David Perera,Mary Jane Cardosa,Peter McMinn,Mong How Ooi,Mong How Ooi +7 more
TL;DR: Enterovirus 71 is a major public health issue across the Asia-Pacific region and beyond, with new outbreaks occurring across Asia in regular cycles, and virus gene subgroups seem to differ in clinical epidemiological properties.