Journal ArticleDOI
Picornavirus and enterovirus diversity with associated human diseases
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TLDR
The Enterovirus genus is a prototype example of the Picornaviridae heterogeneity at both genetic and phenotypic levels and better characterization of these ubiquitous human pathogens may help to develop vaccines or antiviral treatments and to monitor the emergence of new strains.Citations
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DA virus mutant H101 has altered CNS pathogenesis and causes immunosuppression
TL;DR: Investigating how a few changes in the genome of a non-lethal virus can lead to altered disease, from survivable to immunosuppression/death, would provide valuable information into viral pathogenesis.
Journal ArticleDOI
Prevalence and Bayesian Phylogenetics of Enteroviruses Derived From Environmental Surveillance Around Polio Vaccine Switch Period in Shandong Province, China
Chenxu Zhao,Xiaojuan Lin,Feng Ji,Ping Xiong,Yao Liu,Suting Wang,Peng Chen,Qing Xu,Li Zhang,Zexin Tao,Aiqiang Xu,Aiqiang Xu +11 more
TL;DR: The study described the changes of PVs and NPEVs around the polio vaccine switch period and provided meaningful global molecular epidemiological data for further studies of EV-related diseases among the population.
Journal ArticleDOI
Environmental Surveillance through Next-Generation Sequencing to Unveil the Diversity of Human Enteroviruses beyond the Reported Clinical Cases.
Andrés Lizasoain,Daiana Mir,Gisella Masachessi,Adrián Alejandro Farías,Nelida Rodriguez-Osorio,Matías Victoria,Silvia Nates,Rodney Colina +7 more
TL;DR: In this article, the authors presented an updated insight about EV circulating in an important region of South America, and suggests a valuable role of wastewater-based epidemiology in predicting outbreaks before the onset of cases in the community.
Posted ContentDOI
Comparative analysis of the molecular mechanism of resistance to vapendavir across a panel of picornavirus species
Kristina Lanko,Liang Sun,Mathy Froeyen,Pieter Leyssen,Leen Delang,Carmen Mirabelli,Johan Neyts +6 more
TL;DR: The data suggest that vapendavir binding to the capsid of the dependent isolate may be required to stabilize the viral particle and to allow efficient dissemination of the virus.
References
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Book
Virus taxonomy: classification and nomenclature of viruses. Seventh report of the International Committee on Taxonomy of Viruses.
TL;DR: This report builds on the accumulated taxonomic construction of the eight previous reports dating back to 1971 and records the proceedings of the Committee since publication of the last report in 2005.
Journal ArticleDOI
Community study of role of viral infections in exacerbations of asthma in 9-11 year old children.
Sebastian L. Johnston,Philip Pattemore,G. Sanderson,Sandra Smith,F Lampe,Lynn Josephs,P. Symington,S. O'Toole,S. H. Myint,D. A. J. Tyrrell +9 more
TL;DR: This study supports the hypothesis that upper respiratory viral infections are associated with 80-85% of asthma exacerbations in school age children.
Journal ArticleDOI
Mutation rates among RNA viruses
John W. Drake,John J. Holland +1 more
TL;DR: This work describes a simple relation between ribovirus mutation frequencies and mutation rates, applies it to the best (albeit far from satisfactory) available data, and observes a central value for the mutation rate per genome per replication of micro(g) approximately 0.76.
Journal ArticleDOI
Virology, epidemiology, pathogenesis, and control of enterovirus 71.
Tom Solomon,Tom Solomon,Penny Lewthwaite,David Perera,Mary Jane Cardosa,Peter McMinn,Mong How Ooi,Mong How Ooi +7 more
TL;DR: Enterovirus 71 is a major public health issue across the Asia-Pacific region and beyond, with new outbreaks occurring across Asia in regular cycles, and virus gene subgroups seem to differ in clinical epidemiological properties.