Lipidomics reveals a remarkable diversity of lipids in human plasma
Oswald Quehenberger,Aaron M. Armando,Alex Brown,Stephen B. Milne,David S. Myers,Alfred H. Merrill,Sibali Bandyopadhyay,Kristin N. Jones,Samuel Kelly,Rebecca L. Shaner,Cameron Sullards,Elaine Wang,Robert C. Murphy,Robert M. Barkley,Thomas J. Leiker,Christian R. H. Raetz,Ziqiang Guan,Gregory M. Laird,David A. Six,David W. Russell,Jeffrey G. McDonald,Shankar Subramaniam,Eoin Fahy,Edward A. Dennis +23 more
TLDR
The focus of the present study was to define the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids and to quantitatively assessed the levels of over 500 distinct molecular species distributed among the main lipid categories.About:Â
This article is published in Journal of Lipid Research.The article was published on 2010-11-01 and is currently open access. It has received 1065 citations till now. The article focuses on the topics: Lipidomics & Lipidome.read more
Citations
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The Human Serum Metabolome
Nikolaos Psychogios,David Hau,Jun Peng,An Chi Guo,Rupasri Mandal,Souhaila Bouatra,Igor Sinelnikov,Ramanarayan Krishnamurthy,Roman Eisner,Bijaya Gautam,Nelson Young,Jianguo Xia,Craig Knox,Edison Dong,Paul Huang,Zsuzsanna Hollander,Theresa L. Pedersen,Steven R. Smith,Fiona Bamforth,Russell Greiner,Bruce M. McManus,John W. Newman,Theodore L. Goodfriend,David S. Wishart,David S. Wishart +24 more
TL;DR: This work has combined targeted and non-targeted NMR, GC-MS and LC-MS methods with computer-aided literature mining to identify and quantify a comprehensive, if not absolutely complete, set of metabolites commonly detected and quantified (with today's technology) in the human serum metabolome.
Journal ArticleDOI
Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling
Fa-Xing Yu,Bin Zhao,Nattapon Panupinthu,Jenna L. Jewell,Ian Lian,Lloyd H. Wang,Jiagang Zhao,Hai-Xin Yuan,Karen Tumaneng,Hairi Li,Xiang-Dong Fu,Gordon B. Mills,Kun-Liang Guan +12 more
TL;DR: This study identifies extracellular diffusible signals that modulate the Hippo pathway and also establishes the hippo-YAP pathway as a critical signaling branch downstream of GPCR.
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Free Radical Lipid Peroxidation: Mechanisms and Analysis
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Sphingolipid metabolites in inflammatory disease
Michael Maceyka,Sarah Spiegel +1 more
TL;DR: The knowledge gained in this emerging field of sphingolipid metabolism will aid in the development of new therapeutic options for inflammatory disorders.
Journal ArticleDOI
LipidBlast in silico tandem mass spectrometry database for lipid identification
Tobias Kind,Kwang-Hyeon Liu,Kwang-Hyeon Liu,Do Yup Lee,Do Yup Lee,Brian C. DeFelice,John K. Meissen,Oliver Fiehn +7 more
TL;DR: This work provides a freely available computer-generated tandem mass spectral library of 212,516 spectra covering 119,200 compounds from 26 lipid compound classes, including phospholipids, glycerolipid, bacterial lipoglycans and plant glycolipids.
References
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TL;DR: This chapter discusses the physical properties and functional Roles of Lipids in Membranes, as well as the Dynamics of Lipoprotein Transport in the Circulatory System.
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A comprehensive classification system for lipids
Eoin Fahy,Shankar Subramaniam,H. Alex Brown,Christopher K. Glass,Alfred H. Merrill,Robert C. Murphy,Christian R. H. Raetz,David W. Russell,Yousuke Seyama,Walter A. Shaw,Takao Shimizu,Friedrich Spener,Gerrit van Meer,Michael S. VanNieuwenhze,Stephen H. White,Joseph L. Witztum,Edward A. Dennis +16 more
TL;DR: A comprehensive classification of lipids with a common platform that is compatible with informatics requirements has been developed to deal with the massive amounts of data that will be generated by the lipid community.
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Update of the LIPID MAPS comprehensive classification system for lipids
Eoin Fahy,Shankar Subramaniam,Robert C. Murphy,Masahiro Nishijima,Christian R. H. Raetz,Takao Shimizu,Friedrich Spener,Gerrit van Meer,Michael J.O. Wakelam,Edward A. Dennis +9 more
TL;DR: The International Lipid Classification and Nomenclature Committee under the sponsorship of the LIPID MAPS Consortium developed and established a "Comprehensive Classification System for Lipids" based on well defined chemical and biochemical principles and using an ontology that is extensible, flexible, and scalable as mentioned in this paper.
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Quantitative determination of the neutral glycosyl ceramides in human blood
TL;DR: Concentrations of the four glycosyl ceramides in plasma and in erythrocytes were determined for samples from young, healthy males and varied with the complexity of the oligosaccharide moiety and ranged from 94% with glucosyl ceramide to 71% with globoside.