Plasmodium berghei ANKA: selection of resistance to piperaquine and lumefantrine in a mouse model.
Daniel Kiboi,Beatrice Irungu,Bernard Langat,Sergio Wittlin,Reto Brun,Jacques Chollet,Oyindamola O. Abiodun,Joseph K. Ng’ang’a,V.C.S. Nyambati,G.M. Rukunga,A. Bell,Alexis Nzila,Alexis Nzila +12 more
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TLDR
Cross-resistance studies showed that the PQ- resistant line was highly resistant to LM, while the LM-resistant line remained sensitive to PQ, so if the mechanism of resistance is similar in P. berghei and Plasmodium falciparum, the use of LM should not select for PQ resistance.About:
This article is published in Experimental Parasitology.The article was published on 2009-07-01 and is currently open access. It has received 32 citations till now. The article focuses on the topics: Plasmodium berghei & Piperaquine.read more
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Mutations in the cytochrome b gene of Plasmodium berghei conferring resistance to atovaquone
TL;DR: Evidence is provided that the antimalarial activity of atovaquone indeed involves an interaction with the cytochrome b and amino acid residues in the mammalian cy tochrome b which might be critical in determining its relative resistance to atovaaquone are defined.
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Microbiome and imputed metagenome study of crude and refined petroleum-oil-contaminated soils: Potential for hydrocarbon degradation and plant-growth promotion
TL;DR: It is revealed that the RP and CP soils contain microbial communities with excellent metabolic potential for PHC degradation, which showed promising results for future bioaugmentation assisted phytoremediation (BAP) strategies for treating such soils.
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In vivo efficacy and bioavailability of lumefantrine: evaluating the application of Pheroid technology
TL;DR: It is suggested that using the Pro-Pheroid formulation improves the bioavailability of lumefantrine, eliminates the food effect associated with lumefanrine as well as significantly reduces the between subject variability in bioavailability when compared to the reference solution.
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Fitness Cost of Resistance for Lumefantrine and Piperaquine-resistant Plasmodium Berghei in a Mouse Model
TL;DR: The contrasting behaviour of PQ- and LU-resistance phenotypes support similar findings which indicate that even for drugs within the same chemical class, resistance-conferred traits may vary on how they influence parasite fitness and virulence.
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Methylene blue inhibits lumefantrine-resistant Plasmodium berghei.
Victor Irungu Mwangi,Ruth M Mumo,Daniel Kiboi,Sabah A. Omar,Zipporah Ng’ang’a,Hastings Ozwara +5 more
TL;DR: The results indicate that methylene blue at a concentration of 45 mg/kg/day confers over 99% inhibition against lumefantrine- and pyrimethamine-resistant P. berghei for six days, showing the potential use methyleneblue in the development of antimalarials against lumesmodial-and-resistant parasites.
References
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Antimalarial drug resistance.
TL;DR: Widespread use of these drugs could roll back malaria and Artemisinin-derivative combinations are particularly effective, since they act rapidly and are well tolerated and highly effective.
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Identification of an antimalarial synthetic trioxolane drug development candidate.
Jonathan L. Vennerstrom,Sarah Arbe-Barnes,Reto Brun,Susan A. Charman,Francis C. K. Chiu,Jacques Chollet,Yuxiang Dong,Arnulf Dorn,Daniel Hunziker,Hugues Matile,Kylie Anne McIntosh,Maniyan Padmanilayam,Josefina Santo Tomas,Christian Scheurer,Bernard Scorneaux,Yuanqing Tang,Heinrich Urwyler,Sergio Wittlin,William N. Charman +18 more
TL;DR: Here it is described how a synthetic peroxide antimalarial drug development candidate was identified in a collaborative drug discovery project.
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Artemisinin-based combination treatment of falciparum malaria.
TL;DR: Most malaria endemic countries have now adopted artemisinin-based combination treatments as first-line treatment of falciparum malaria, but in most of these only a minority of the patients that need artesunate-mefloquine, artemether-lumefantrine, and dihydroartemisin in-piperaquine actually receive them.
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The chemotherapy of rodent malaria, XXII. The value of drug-resistant strains of P. berghei in screening for blood schizontocidal activity.
TL;DR: It is concluded that the in vivo tests do provide a valuable indication of the potential use of a compound against drug-resistant malaria parasites of man and of the future value of new compounds against strains of parasites that are already resistant to chloroquine.
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Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin.
Amar Bir Singh Sidhu,Anne-Catrin Uhlemann,Stephanie G. Valderramos,Juan Carlos Valderramos,Sanjeev Krishna,David A. Fidock +5 more
TL;DR: The importance of pfmdr1 copy number in determining P. falciparum susceptibility to multiple agents currently being used to combat malaria caused by multidrug-resistant parasites is highlighted.