Journal ArticleDOI
Polymeric nano- and microparticles for the oral delivery of peptides and peptidomimetics
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TLDR
The aim of this paper is to review the principal studies where peptide-loaded particles were administered by the oral route and in vivo results are discussed with emphasis placed on the peptide blood levels reached or on the biological effects observed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 1998-12-01. It has received 248 citations till now.read more
Citations
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Journal ArticleDOI
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues.
TL;DR: The tenacious mucus barrier properties that have precluded the efficient penetration of therapeutic particles are described and the design and development of new mucus-penetrating particles that may avoid rapid mucus clearance mechanisms are reviewed to provide targeted or sustained drug delivery for localized therapies in mucosal tissues.
Journal ArticleDOI
Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles.
TL;DR: In this review the most important preparation methods are described, especially those that make use of natural polymers, andvantages and disadvantages will be presented so as to facilitate selection of an appropriate nanoencapsulation method according to a particular application.
Journal ArticleDOI
Food protein-based materials as nutraceutical delivery systems
TL;DR: The potential role of food proteins as substrate for the development of nutraceutical delivery systems in the form of hydrogel, micro-, or nano- particles is described.
Journal ArticleDOI
Methods for the preparation and manufacture of polymeric nanoparticles.
TL;DR: This review summarizes the different methods of preparation of polymer nanoparticles including nanospheres and nanocapsules and presents the most recent innovations and progresses obtained over the last decade.
Journal ArticleDOI
Miniemulsion Polymerization and the Structure of Polymer and Hybrid Nanoparticles
TL;DR: The miniemulsion process allows the formation of complex structured polymeric nanoparticles and the encapsulation of a solid or liquid, an inorganic or organic, or a hydrophobic or hydrophilic material into a polymer shell.
References
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Journal ArticleDOI
Gastrointestinal uptake of biodegradable microparticles: effect of particle size.
TL;DR: There is a microparticle size dependent exclusion phenomena in the gastrointestinal mucosal tissue with 100 nm size particles showing significantly greater tissue uptake, which has important implications in designing of nanoparticle-based oral drug delivery systems, such as an oral vaccine system.
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Nanoparticle uptake by the rat gastrointestinal mucosa : quantitation and particle size dependency
TL;DR: Measurement of radioactivity of tissues following administration of 100 nm and 1 μm I125‐labelled polystyrene latex particles for 8 days was corroborative although less secure because of the potential lability of the labelled particles.
Journal ArticleDOI
HIV-1 protease inhibitors. A review for clinicians.
TL;DR: A systematic review of peer-reviewed publications, abstracts from national and international conferences, and product registration information through September 1996 is presented in this paper, where the authors assess the available data to aid clinicians and patients in choosing appropriate treatment.
Journal ArticleDOI
The oral absorption of micro- and nanoparticulates: neither exceptional nor unusual.
TL;DR: It is concluded that there is now no dispute over the fact that particulate uptake does take place, not only via the M-cells in the Peyer's patches and the isolated follicles of the gut-associated lymphoid tissue, but also via the normal intestinal enterocytes.
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