Poor replication of candidate genes for major depressive disorder using genome-wide association data
Fokko J. Bosker,Catharina A. Hartman,Ilja M. Nolte,Bram P. Prins,Peter Terpstra,Danielle Posthuma,T. van Veen,Gonneke Willemsen,Roel H. DeRijk,E.J.C. de Geus,Witte J.G. Hoogendijk,Patrick F. Sullivan,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Dorret I. Boomsma,Harold Snieder,Willem A. Nolen +16 more
TLDR
Support for involvement in MDD for only four genes is found, which may point to publication bias and false-positive findings in previous candidate gene studies, and may also be related to heterogeneity of the MDD phenotype as well as contextual genetic or environmental factors.Abstract:
Poor replication of candidate genes for major depressive disorder using genome-wide association dataread more
Citations
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Journal ArticleDOI
Major depressive disorder
Christian Otte,Stefan M. Gold,Stefan M. Gold,Brenda W.J.H. Penninx,Carmine M. Pariante,Amit Etkin,Maurizio Fava,David C. Mohr,Alan F. Schatzberg +8 more
TL;DR: An overview of the current evidence of major depressive disorder, including its epidemiology, aetiology, pathophysiology, diagnosis and treatment, is provided.
Journal ArticleDOI
A Critical Review of the First 10 Years of Candidate Gene-by-Environment Interaction Research in Psychiatry
TL;DR: Gene-by-environment interaction studies in psychiatry have typically been conducted using a candidate G×E (cG×E) approach, analogous to the candidate gene association approach used to test genetic main effects, yet cG–E findings remain controversial.
Journal ArticleDOI
Inflammatory cytokines in depression: Neurobiological mechanisms and therapeutic implications
TL;DR: This review explores the idea that specific gene polymorphisms and neurotransmitter systems can confer protection from or vulnerability to specific symptom dimensions of cytokine-related depression and potential therapeutic strategies that target inflammatory cytokine signaling.
Journal ArticleDOI
Gene × Environment Interaction Studies Have Not Properly Controlled for Potential Confounders: The Problem and the (Simple) Solution
TL;DR: This manuscript demonstrates that the practice of improperly controlling for covariates is the norm in the G × E interaction literature to date and shows that many alternative explanations for G ×E findings that investigators had thought were eliminated have not been.
Journal ArticleDOI
The genetics of major depression.
TL;DR: Genome-wide association and linkage results provide constraints on the allele frequencies and effect sizes of susceptibility loci, which are used to interpret the voluminous candidate gene literature.
References
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TL;DR: This study has demonstrated that careful use of a shared control group represents a safe and effective approach to GWA analyses of multiple disease phenotypes; generated a genome-wide genotype database for future studies of common diseases in the British population; and shown that, provided individuals with non-European ancestry are excluded, the extent of population stratification in theBritish population is generally modest.
Journal ArticleDOI
The Wellcome Trust Case Control Consortium, U.K.
TL;DR: This article reports that the magazine's award for Research Leader of the Year was given to the Wellcome Trust Case Control Consortium which conducted a huge genetic study to look at the genetic causes for various diseases.
Journal ArticleDOI
A new multipoint method for genome-wide association studies by imputation of genotypes
TL;DR: This work proposes a coherent analysis framework that treats the genome-wide association problem as one involving missing or uncertain genotypes, and proposes a model-based imputation method for inferring genotypes at observed or unobserved SNPs, leading to improved power over existing methods for multipoint association mapping.
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