Inflammatory cytokines in depression: Neurobiological mechanisms and therapeutic implications
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TLDR
This review explores the idea that specific gene polymorphisms and neurotransmitter systems can confer protection from or vulnerability to specific symptom dimensions of cytokine-related depression and potential therapeutic strategies that target inflammatory cytokine signaling.About:
This article is published in Neuroscience.The article was published on 2013-08-29 and is currently open access. It has received 771 citations till now. The article focuses on the topics: Proinflammatory cytokine & Cytokine.read more
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The Lancet Commission on global mental health and sustainable development.
Vikram Patel,Shekhar Saxena,Crick Lund,Crick Lund,Graham Thornicroft,Florence Baingana,Paul Bolton,Dan Chisholm,Pamela Y. Collins,Janice Cooper,Janice Cooper,Julian Eaton,Helen Herrman,Helen Herrman,Mohammad M. Herzallah,Mohammad M. Herzallah,Yueqin Huang,Mark J. D. Jordans,Mark J. D. Jordans,Arthur Kleinman,María Elena Medina-Mora,Ellen Morgan,Unaiza Niaz,Unaiza Niaz,Olayinka Omigbodun,Martin Prince,Atif Rahman,Benedetto Saraceno,Bidyut K. Sarkar,Mary De Silva,Ilina Singh,Dan J. Stein,Dan J. Stein,Dan J. Stein,Charlene Sunkel,Jürgen Unützer +35 more
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Psychobiotics and the Manipulation of Bacteria-Gut-Brain Signals.
TL;DR: The definition of psychobiotics be expanded beyond probiotics and prebiotics to include other means of influencing the microbiome, and several important research questions and issues are tabulated.
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Vagus Nerve as Modulator of the Brain-Gut Axis in Psychiatric and Inflammatory Disorders.
TL;DR: Various functions of the vagus nerve are discussed, which make it an attractive target in treating psychiatric and gastrointestinal disorders and preliminary evidence for gut bacteria to have beneficial effect on mood and anxiety, partly by affecting the activity of thevagus nerve.
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Inflamed moods: a review of the interactions between inflammation and mood disorders.
TL;DR: This synthetic review is to review the evidence for an association between inflammation and mood disorders, to discuss potential pathophysiologic mechanisms that may explain this association and to present novel therapeutic options currently being investigated that target the inflammatory-mood pathway.
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Anxiety and depression comorbidities in irritable bowel syndrome (IBS): a systematic review and meta-analysis.
Guillaume Fond,Anderson Loundou,Nora Hamdani,Wahid Boukouaci,Aroldo A. Dargél,José Oliveira,Matthieu Roger,Ryad Tamouza,Marion Leboyer,Laurent Boyer +9 more
TL;DR: In conclusion, anxiety and depression symptomatology should be systematically checked and treated in IBS patients, as psychological factors are important moderators of symptom severity, symptom persistence, decisions to seek treatment, and response to treatment.
References
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Obesity is associated with macrophage accumulation in adipose tissue
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Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
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From inflammation to sickness and depression: when the immune system subjugates the brain
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