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Open AccessJournal ArticleDOI

Potential Interventions for Novel Coronavirus in China: A Systematic Review

Lei Zhang, +1 more
- 01 May 2020 - 
- Vol. 92, Iss: 5, pp 479-490
TLDR
It is suggested that all the potential interventions be implemented to control the emerging COVID‐19 if the infection is uncontrollable and the current children's RNA‐virus vaccines including influenza vaccine should be immunized for uninfected people and health care workers.
Abstract
An outbreak of a novel coronavirus (COVID-19 or 2019-CoV) infection has posed significant threats to international health and the economy. In the absence of treatment for this virus, there is an urgent need to find alternative methods to control the spread of disease. Here, we have conducted an online search for all treatment options related to coronavirus infections as well as some RNA-virus infection and we have found that general treatments, coronavirus-specific treatments, and antiviral treatments should be useful in fighting COVID-19. We suggest that the nutritional status of each infected patient should be evaluated before the administration of general treatments and the current children's RNA-virus vaccines including influenza vaccine should be immunized for uninfected people and health care workers. In addition, convalescent plasma should be given to COVID-19 patients if it is available. In conclusion, we suggest that all the potential interventions be implemented to control the emerging COVID-19 if the infection is uncontrollable.

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Citations
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A Review of Coronavirus Disease-2019 (COVID-19).

TL;DR: The disease is mild in most people; in some (usually the elderly and those with comorbidities), it may progress to pneumonia, acute respiratory distress syndrome (ARDS) and multi organ dysfunction and many people are asymptomatic.
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Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults.

TL;DR: The coronavirus disease 2019 (COVID‐19) pandemic has affected hundreds of thousands of people and data on symptoms and prognosis in children are rare.
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Molecular immune pathogenesis and diagnosis of COVID-19.

TL;DR: A brief introduction of the general features of SARS-CoV-2 is provided and current knowledge of molecular immune pathogenesis, diagnosis and treatment of COVID-19 is discussed, which may be helpful in offering novel insights and potential therapeutic targets for combating the SARS/MERS/CoV infection.
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Coronavirus Disease 2019–COVID-19

TL;DR: Analysis of epidemiological, diagnostic, clinical, and therapeutic aspects, including perspectives of vaccines and preventive measures that have already been globally recommended to counter this pandemic virus, suggest that this novel virus has been transferred from an animal source, such as bats.
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COVID-19 diagnosis and management: a comprehensive review.

TL;DR: An overview of the known clinical features and treatment options for COVID‐19 is provided and quarantine is the only intervention that appears to be effective in decreasing the contagion rate.
References
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Journal ArticleDOI

A Novel Coronavirus from Patients with Pneumonia in China, 2019.

TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI

Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial.

TL;DR: In patients with chronic hepatitis C, the most effective therapy is the combination of peginterferon alfa-2b 1.5 microg/kg per week plus ribavirin, and this randomised trial found that the benefit is mostly achieved in patients with HCV genotype 1 infections.
Journal ArticleDOI

Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.

TL;DR: It is found that a soluble form of ACE2, but not of the related enzyme ACE1, blocked association of the S1 domain with Vero E6 cells, indicating that ACE2 is a functional receptor for SARS-CoV.
Journal ArticleDOI

First Case of 2019 Novel Coronavirus in the United States.

TL;DR: This case highlights the importance of close coordination between clinicians and public health authorities at the local, state, and federal levels, as well as the need for rapid dissemination of clinical information related to the care of patients with this emerging infection.
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Here, we have conducted an online search for all treatment options related to coronavirus infections as well as some RNA‐virus infection and we have found that general treatments, coronavirus‐specific treatments, and antiviral treatments should be useful in fighting COVID‐19.