Journal ArticleDOI
Preparation and in vitro evaluation of Eudragit microspheres containing acetazolamide.
S. Haznedar,Betül Dortunç +1 more
TLDR
Although acetazolamide release rates from Eudragit RS microspheres were very slow and incomplete for all formulations, they were fast from EUDragit RL microsphere formulations.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2004-01-09. It has received 235 citations till now. The article focuses on the topics: Controlled release & Liquid paraffin.read more
Citations
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Journal ArticleDOI
Advances in oral nano-delivery systems for colon targeted drug delivery in inflammatory bowel disease: selective targeting to diseased versus healthy tissue.
TL;DR: The authors described and discussed the various approaches current nano-delivery systems can offer in overcoming the limitations of conventional drug formulations and the future advances of this research are discussed.
Journal Article
Microencapsulation: a promising technique for controlled drug delivery
TL;DR: A closer look is taken at microparticles as drug delivery devices for increasing efficiency of drug delivery, improving the release profile and drug targeting, in order to appreciate the application possibilities of microcapsules in drug delivery.
Journal ArticleDOI
Preparation and characterization of a novel pH-sensitive chitosan-g-poly (acrylic acid)/attapulgite/sodium alginate composite hydrogel bead for controlled release of diclofenac sodium
TL;DR: A series of pH-sensitive composite hydrogel beads composed of chitosan-g -poly (acrylic acid)/attapulgite/sodium alginate (CTS- g -PAA/APT/SA) was prepared as drug delivery matrices crosslinked by Ca 2+ owing to the ionic gelation of SA as discussed by the authors.
Journal ArticleDOI
Evaluation of ciprofloxacin-loaded Eudragit® RS100 or RL100/PLGA nanoparticles
TL;DR: In this paper, two non-biodegradable positively charged polymers, Eudragit RS100 and RL100, and the biodegradability polymer poly(lactic-co-glycolic acid) or PLGA were used alone or in combination, with varying ratios.
Journal ArticleDOI
Release characteristics of diclofenac sodium from poly(vinyl alcohol)/sodium alginate and poly(vinyl alcohol)-grafted-poly(acrylamide)/sodium alginate blend beads.
Oya Şanlı,Nuran Ay,Nuran Işıklan +2 more
TL;DR: It was observed that, DS release from the beads decreased with increasing PVA/NaAlg (m/m) ratio, drug/polymer ratio (d/p) and extent of cross-linking, but release increased with increasing acrylamide content of the PVA-g-PAAm polymer.
References
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Journal ArticleDOI
Preparation of biodegradable microspheres and microcapsules: 2. Polyactides and related polyesters
TL;DR: A general survey of the manufacturing methods of microspheres and microcapsules based on biodegradable polyesters, including polylactides, polyglycolide, polyhydroxybutyrate, polycaprolactone, polycarbonates and related copolymers is presented in this paper.
Journal ArticleDOI
Preparation of Controlled-Release Microspheres of Ibuprofen With Acrylic Polymers by a Novel Quasi-Emulsion Solvent Diffusion Method
TL;DR: A quasi-emulsion solvent diffusion method to prepare the controlled-release microspheres of ibuprofen with acrylic polymers has been developed in this article, where an ethanol solution of ibUprofen and acrylic resin was poured into aqueous medium with stirring.
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Polymeric microspheres as drug carriers
Stanley S. Davis,Lisbeth Illum +1 more
TL;DR: Data are presented which show that by the selection of the appropriate coating material it is possible to direct particles within the body to sites such as the lung, liver, bone marrow, or to retain materials within the systemic circulation.
Journal ArticleDOI
Albumin microspheres and microcapsules: Methodology of manufacturing techniques
TL;DR: In this paper, a methodological review of the preparation of albumin nano/microspheres and nano-microcapsules by suspension crosslinking is presented, and the dependence of microcapsule characteristics, namely hydration, biodegradability and core release, are also outlined.
Journal ArticleDOI
The design and evaluation of controlled release systems for the gastrointestinal tract
TL;DR: The non-invasive technique of gamma scintigraphy has been used to follow in vivo release rates and to relate these to pharmacokinetic parameters and this result has implications for the design of controlled release delivery systems for drugs with poor absorption in the large intestine, as well as for the development of positioned release systems (colon targeting).