Journal ArticleDOI
Protein intrinsic disorder-based liquid-liquid phase transitions in biological systems: Complex coacervates and membrane-less organelles.
TLDR
This review considers several biologically relevant liquid-liquid phase transitions, introduces some general features attributed to intrinsically disordered proteins, represents several illustrative examples of intrinsic disorder-based phase separation, and provides some reasons for the abundance of intrinsically dis ordered proteins in organelles formed as a result of biological liquid- liquid phase transitions.About:
This article is published in Advances in Colloid and Interface Science.The article was published on 2017-01-01. It has received 173 citations till now. The article focuses on the topics: Intrinsically disordered proteins.read more
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Book ChapterDOI
Intrinsically Disordered Proteins
TL;DR: This Sprenger Briefs volume is dedicated to IDPs and IDPRs and an attempt is made to compress a massive amount of knowledge and into a digest that aims to be of use to those wishing a fast entry into this promising field of structural biology.
Journal ArticleDOI
Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder
TL;DR: The goal of this review is to show the roles of intrinsic disorder in the magic behind biological liquid-liquid phase transitions that lead to the formation of PMLOs, which are crucially dependent on intrinsic disorder.
Journal ArticleDOI
Sequence determinants of protein phase behavior from a coarse-grained model.
TL;DR: A novel simulation method to determine thermodynamic phase diagrams as a function of the total protein concentration and temperature is developed and is capable of capturing qualitative changes in the phase diagram due to phosphomimetic mutations of FUS and to the presence or absence of the large folded domain in LAF-1.
Journal ArticleDOI
Intrinsically Disordered Proteins and Their “Mysterious” (Meta)Physics
TL;DR: With their exceptional spatio-temporal heterogeneity and high conformational flexibility, IDPs/IDPRs represent complex systems that act at the edge of chaos and are specifically tunable by various means.
Journal ArticleDOI
α-Synuclein misfolding and aggregation: Implications in Parkinson's disease pathogenesis.
TL;DR: The structural and functional aspects of α-Syn and role of potential factors that may contribute to the underlying mechanism of synucleinopathies are focused on to identify novel targets and develop specific therapeutic strategies to combat Parkinson's and other protein aggregation related neurodegenerative diseases.
References
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Crystal structure of the nucleosome core particle at 2.8 Å resolution
TL;DR: The X-ray crystal structure of the nucleosome core particle of chromatin shows in atomic detail how the histone protein octamer is assembled and how 146 base pairs of DNA are organized into a superhelix around it.
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Hydrogel: Preparation, characterization, and applications: A review
TL;DR: A review of the literature concerning classification of hydrogels on different bases, physical and chemical characteristics of these products, and technical feasibility of their utilization is presented in this paper, together with technologies adopted for hydrogel production together with process design implications, block diagrams, and optimized conditions of the preparation process.
Journal ArticleDOI
The Role of Chromatin during Transcription
TL;DR: This Review highlights advances in the understanding of chromatin regulation and discusses how such regulation affects the binding of transcription factors as well as the initiation and elongation steps of transcription.
Journal ArticleDOI
Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm.
Peter E. Wright,H. Jane Dyson +1 more
TL;DR: Many proteins that lack intrinsic globular structure under physiological conditions have now been recognized, and it appears likely that their rapid turnover, aided by their unstructured nature in the unbound state, provides a level of control that allows rapid and accurate responses of the cell to changing environmental conditions.
Journal ArticleDOI
Chromatin structure: a repeating unit of histones and DNA.
TL;DR: Preliminary results do show less cross-linking of histones in chromatin than in solution, but crosslinked products up to pentamers are readily observed and call for further investigation.