Pulmonary pathology of severe acute respiratory syndrome in Toronto.
David M. Hwang,Dean Chamberlain,Susan M. Poutanen,Donald E. Low,Sylvia L. Asa,Jagdish Butany +5 more
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TLDR
It is indicated that the lungs of patients who die of SARS are almost always positive for the SARS-associated coronavirus by RT-PCR, and may show features of both diffuse alveolar damage and acute fibrinous and organizing pneumonia patterns of acute injury.About:
This article is published in Modern Pathology.The article was published on 2005-01-01 and is currently open access. It has received 294 citations till now. The article focuses on the topics: Diffuse alveolar damage & Lung injury.read more
Citations
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Pulmonary Pathology of Early-Phase 2019 Novel Coronavirus (COVID-19) Pneumonia in Two Patients With Lung Cancer.
TL;DR: Pathologic examinations revealed that apart from the tumors, the lungs of both patients exhibited edema, proteinaceous exudate, focal reactive hyperplasia of pneumocytes with patchy inflammatory cellular infiltration, and multinucleated giant cells, which likely represent an early phase of the lung pathology of COVID-19 pneumonia.
Journal ArticleDOI
SARS: Systematic Review of Treatment Effects
TL;DR: It was not possible to determine whether treatments benefited patients during the SARS outbreak, but clinical trials should be designed to validate a standard protocol for dosage and timing and to accrue data in real time during future outbreaks to monitor specific adverse effects and help inform treatment.
Journal ArticleDOI
Co-infections in people with COVID-19: a systematic review and meta-analysis.
TL;DR: A low proportion of COVID-19 patients have a bacterial co-infection; less than in previous influenza pandemics; and these findings do not support the routine use of antibiotics in the management of confirmed CO VID-19 infection.
Journal ArticleDOI
Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study.
Luca Carsana,Aurelio Sonzogni,Ahmed Nasr,Roberta Simona Rossi,Alessandro Pellegrinelli,Pietro Zerbi,Roberto Rech,Riccardo Colombo,Spinello Antinori,Mario Corbellino,Massimo Galli,Emanuele Catena,Antonella Tosoni,Andrea Gianatti,Manuela Nebuloni +14 more
TL;DR: The predominant pattern of lung lesions in patients with COVID-19 patients is diffuse alveolar damage, as described in patients infected with severe acute respiratory syndrome and Middle East respiratory syndrome coronaviruses.
Journal ArticleDOI
Postmortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction.
Thomas Menter,Jasmin D. Haslbauer,Ronny Nienhold,Spasenija Savic,Helmut Hopfer,Nikolaus Deigendesch,Stephan Frank,Daniel Turek,Niels Willi,Hans Pargger,Stefano Bassetti,Joerg D. Leuppi,Gieri Cathomas,Markus Tolnay,Kirsten D. Mertz,Alexandar Tzankov +15 more
TL;DR: The general extent of organ involvement and the microscopic changes in the lungs remain insufficiently characterised, and autopsies are essential to elucidate COVID‐19‐associated organ alterations.
References
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Identification of a novel coronavirus in patients with severe acute respiratory syndrome.
Christian Drosten,Stephan Günther,Wolfgang Preiser,Sylvie van der Werf,H. R. Brodt,Stephan Becker,Holger F. Rabenau,Marcus Panning,Larissa Kolesnikova,Ron A. M. Fouchier,Annemarie Berger,Ana-Maria Burguière,Jindrich Cinatl,Markus Eickmann,Nicolas Escriou,Klaus Grywna,Stefanie Kramme,Jean-Claude Manuguerra,Stefanie Müller,Volker Rickerts,Martin Stürmer,Simon Vieth,Hans-Dieter Klenk,Albert D. M. E. Osterhaus,Herbert Schmitz,Hans Wilhelm Doerr +25 more
TL;DR: The novel coronavirus might have a role in causing SARS and was detected in a variety of clinical specimens from patients with SARS but not in controls.
Journal ArticleDOI
A novel coronavirus associated with severe acute respiratory syndrome.
Thomas G. Ksiazek,Dean D. Erdman,Cynthia S. Goldsmith,Zaki,Teresa C. T. Peret,Shannon L. Emery,Suxiang Tong,Urbani C,James A. Comer,Wilina Lim,Pierre E. Rollin,Scott F. Dowell,Ai Ee Ling,Charles D. Humphrey,Wun-Ju Shieh,Jeannette Guarner,Christopher D. Paddock,Paul A. Rota,Barry S. Fields,Joseph L. DeRisi,Jyh-Yuan Yang,Nancy J. Cox,James M. Hughes,James W. LeDuc,William J. Bellini,Larry J. Anderson +25 more
TL;DR: A novel coronavirus is associated with this outbreak of severe acute respiratory syndrome, and the evidence indicates that this virus has an etiologic role in SARS.
Journal ArticleDOI
Coronavirus as a possible cause of severe acute respiratory syndrome
Jsm Peiris,Sik To Lai,Llm Poon,Yi Guan,Lyc Yam,Wilina Lim,John M. Nicholls,Wks Yee,WW Yan,MT Cheung,V. C. C. Cheng,KH Chan,Dnc Tsang,R Yung,Ting Kin Ng,KY Yuen +15 more
TL;DR: Serological and molecular tests specific for the virus permitted a definitive laboratory diagnosis to be made and allowed further investigation to define whether other cofactors play a part in disease progression.
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A Major Outbreak of Severe Acute Respiratory Syndrome in Hong Kong
Nelson Lee,David S.C. Hui,Alan Wu,Paul K.S. Chan,Peter Cameron,Gavin M. Joynt,Anil T. Ahuja,Man Yee Yung,Chi-Bon Leung,Ka Fai To,Siu F. Lui,Cheuk-Chun Szeto,S.C.Sydney Chung,Joseph J.Y. Sung +13 more
TL;DR: SARS is a serious respiratory illness that led to significant morbidity and mortality in this cohort of 138 cases of suspected SARS during a hospital outbreak in Hong Kong.
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The severe acute respiratory syndrome.
TL;DR: The concerted and coordinated response that contained SARS is a triumph for global public health and provides a new paradigm for the detection and control of future emerging infectious disease threats.
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