Journal ArticleDOI
Purine analog inhibitors of xanthine oxidase: structure activity relationships and proposed binding of the molybdenum cofactor
Roland K. Robins,G. R. Revankar,Darrell E. O'Brien,Robert H. Springer,Thomas Novinson Anthony Albert,Keitaro Senga,Jon P. Miller,David G. Streeter +7 more
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TLDR
In this article, a number of new hypoxanthine analogs have been prepared as substrate inhibitors of xanthine oxidase, and the structure-activity relationships of these new phenyl substitutions are discussed and compared with the 3-m-tolyl- and 3-phenyl-7-hydroxypyrazolo[1,5-a]pyrimidin-5-ones.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 1985-05-01. It has received 102 citations till now. The article focuses on the topics: Xanthine oxidase & Xanthine dehydrogenase.read more
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Therapeutic strategies by modulating oxygen stress in cancer and inflammation.
TL;DR: A unique therapeutic strategy was developed named "oxidation therapy", by delivering cytotoxic ROS directly to the solid tumor, or alternatively inhibiting the antioxidative enzyme system, such as HO-1 in tumor, to achieve the objective of tumor targeting and thus reducing side effects.
Journal ArticleDOI
Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase.
Ben L.J. Godber,Justin J. Doel,Gopal P. Sapkota,David R. Blake,Cliff R. Stevens,Robert Eisenthal,Roger Harrison +6 more
TL;DR: Xanthine oxidase was shown to catalyze the reduction of nitrite to nitric oxide (NO) in the presence of either NADH or xanthine as reducing substrate, and it is proposed that XO-derived NO fulfills a bactericidal role in the digestive tract.
Journal ArticleDOI
Synthesis and antiviral evaluation of some new pyrazole and fused pyrazolopyrimidine derivatives.
Aymn E. Rashad,Mohamed I. Hegab,Randa E. Abdel-Megeid,Jehan A. Micky,Farouk M. E. Abdel-Megeid +4 more
TL;DR: The antiviral evaluation of some selected new products showed that they have promising antiviral activity against hepatitis-A virus (HAV) and herpes simplex virus type-1 (HSV-1).
Journal ArticleDOI
The biological potential of flavones
Alok K. Verma,Ram Pratap +1 more
TL;DR: In this review, the roles of flavones in various metabolic and systemic disease models are discussed and their structure–activity relationships have generated interest among medicinal chemists.
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Tandem Orientation of Duplicated Xanthine Dehydrogenase Genes from Arabidopsis thaliana DIFFERENTIAL GENE EXPRESSION AND ENZYME ACTIVITIES
TL;DR: It was found that AtXDH1 is a strict dehydrogenase and not an oxidase, but is able to produce superoxide radicals indicating that besides purine catabolism it might also be involved in response to various stresses that require reactive oxygen species.
References
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Ischemic injury in the cat small intestine: Role of superoxide radicals
Dale A. Parks,Dale A. Parks,Gregory B. Bulkley,Gregory B. Bulkley,D. Neil Granger,D. Neil Granger,Stanley R. Hamilton,Stanley R. Hamilton,Joe M. McCord,Joe M. McCord +9 more
TL;DR: The results of this study suggest that superoxide radicals are involved in the pathogenesis of ischemic mucosal lesions and that the enzyme xanthine oxidase is the source ofsuperoxide radicals in the isChemic small bowel.
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On the Mechanism of Inactivation of Xanthine Oxidase by Allopurinol and Other Pyrazolo[3,4-d]pyrimidines
TL;DR: It is concluded that the best preparations of xanthine oxidase so far obtained contain only 75 to 80% functional active sites, even though they possess their full complement of flavin, molybdenum, and iron-sulfur components.
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The Mechanism of Action of Xanthine Oxidase
TL;DR: It is concluded that the iron-sulfur centers act as an electron reservoir functioning to maintain molybdenum as Mo(VI) (for efficient reduction) and flavin as FADH2 ( for efficient oxidation).
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Characterization of the molybdenum cofactor of sulfite oxidase, xanthine, oxidase, and nitrate reductase. Identification of a pteridine as a structural component.
TL;DR: In this paper, the molybdenum cofactor has been isolated in an oxidized inactive form from purified molybinenzymes, and the isolated material is shown to be a novel pterin.
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Structural and metabolic relationship between the molybdenum cofactor and urothione.
Jean L. Johnson,K.V. Rajagopalan +1 more
TL;DR: The finding that urine samples from patients deficient in the molybdenum cofactor are devoid of urothione demonstrates a metabolic link between the two molecules, and a structural relationship is suggested.