Journal ArticleDOI
Putative pathophysiological interactions of cytokines and phagocytic cells in severe human falciparum malaria
TLDR
The putative mechanisms by which cytokines may mediate both beneficial and deleterious effects by activating phagocytic cells in severe falciparum malaria are discussed.Abstract:
The severe disease and high mortality associated with Plasmodium falciparum infection have traditionally been attributed solely to parasitic virulence factors, but more recent evidence suggests that the host's immunologic response may also contribute to the pathophysiology of the disease in humans. This response would be expected to be proportionate--in intensity and nature--to the antigenic load created by the sequestration of parasites in the microvasculature and to be directed against the sites of maximal parasitization; thus the immunologic response could potentially contribute to the pathophysiology of both survival and fatal outcome in severe infection. Cytokines appear to play a pivotal role in the activation of the immune response in human falciparum malaria, and their levels correlate with disease severity. The putative mechanisms by which cytokines may mediate both beneficial and deleterious effects by activating phagocytic cells in severe falciparum malaria are discussed.read more
Citations
More filters
Journal ArticleDOI
Intervillous macrophage migration inhibitory factor is associated with adverse birth outcomes in a study population in Central India.
Puspendra P. Singh,Naomi W. Lucchi,Anna J. Blackstock,Anna J. Blackstock,Venkatachalam Udhayakumar,Neeru Singh,Neeru Singh +6 more
TL;DR: The hypothesis that elevated concentrations of placental MIF may be associated with an increased risk of adverse birth outcome is supported, supported by the odds of stillbirth and low birth weight deliveries for the uppermost placential MIF quartile.
Journal ArticleDOI
Macrophage migration inhibitory factor homolog from Plasmodium yoelii modulates monocyte recruitment and activation in spleen during infection
Yanhui Zhang,Yanhui Zhang,Kazutoyo Miura,Jian Li,Jian Li,Gregory Tullo,Feng Zhu,Lingxian Hong,Tianlong Lin,Xin-zhuan Su,Xin-zhuan Su,Carole A. Long +11 more
TL;DR: Results indicate that PyMIF potentially modulates monocyte recruitment and activation during infection of P. yoelii erythrocytic stages.
Dissertation
Host Inflammatory Pathways in Malaria Infection: Potential Therapeutic Targets and Biomarkers of Disease Severity
TL;DR: Findings identify host responses as putative targets for adjunctive therapies, and suggest the utility of host biomarker combinations as prognostic tests for severe malaria.
Dissertation
Analyses of class and subclass antibody of circulating immune complexes in children with severe Plasmodium Falciparummalaria in endemic regions of Western Kenya
TL;DR: A thesis submitted in fulfilment of the requirement for the Degree of doctor of Philosophy in Immunology in the School of Health Sciences of Kenyatta University.
References
More filters
Journal ArticleDOI
Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils.
TL;DR: It has been shown that CSa, formylmethionyl peptides, PAF, and LTB4 act via unrelated receptors, suggesting that neutrophil recruitment can result from the concerted action of multiple stimuli.
Journal ArticleDOI
Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs
Carl J. March,Bruce Mosley,Larsen Alf D,Douglas P. Cerretti,Gary Braedt,Virginia L. Price,Steven Gillis,Christopher S. Henney,Shirley R. Kronheim,Kenneth H. Grabstein,Paul J. Conlon,Thomas P. Hopp,David Cosman +12 more
TL;DR: Two distinct but distantly related complementary DNAs encoding proteins sharing human interleukin-1 (IL-1) activity (termed IL-lα and IL-1β), were isolated from a macrophage cDNA library.
Journal ArticleDOI
Biology of interleukin 1.
TL;DR: IL 1 is a highly inflammatory molecule and stimulates the production of arachidonic acid metabolites and acts synergistically with other cytokines, particularly tumor necrosis factor.
Journal Article
Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon.
Jordan S. Pober,Michael A. Gimbrone,Lynne A. Lapierre,D L Mendrick,Walter Fiers,Robert Rothlein,Timothy A. Springer +6 more
TL;DR: The authors used the quantitative binding of murine monoclonal antibodies to the surface of cultured human umbilical vein endothelial (HUVE) cells to study the responses of HUVE cells to three different immune mediators: interleukin 1 (IL 1), tumor necrosis factor (TNF), and immune interferon (IFN-gamma) antigens.