Journal ArticleDOI
Putative pathophysiological interactions of cytokines and phagocytic cells in severe human falciparum malaria
TLDR
The putative mechanisms by which cytokines may mediate both beneficial and deleterious effects by activating phagocytic cells in severe falciparum malaria are discussed.Abstract:
The severe disease and high mortality associated with Plasmodium falciparum infection have traditionally been attributed solely to parasitic virulence factors, but more recent evidence suggests that the host's immunologic response may also contribute to the pathophysiology of the disease in humans. This response would be expected to be proportionate--in intensity and nature--to the antigenic load created by the sequestration of parasites in the microvasculature and to be directed against the sites of maximal parasitization; thus the immunologic response could potentially contribute to the pathophysiology of both survival and fatal outcome in severe infection. Cytokines appear to play a pivotal role in the activation of the immune response in human falciparum malaria, and their levels correlate with disease severity. The putative mechanisms by which cytokines may mediate both beneficial and deleterious effects by activating phagocytic cells in severe falciparum malaria are discussed.read more
Citations
More filters
Journal Article
Cytokines and their role in modulating the severity of Plasmodium falciparum malaria
TL;DR: Measuring the ratios of the opposing groups of cytokines can hence, provide clues to predict the prognosis of the disease and help in determining the outcome of malaria infection.
Journal ArticleDOI
Intestinal helminths as predictors of some malaria clinical outcomes and IL-1β levels in outpatients attending two public hospitals in Bamenda, North West Cameroon
TL;DR: In this article, the impact of intestinal helminths on malaria parasitaemia, anaemia and pyrexia considering the levels of IL-1β among outpatients in Bamenda.
Journal Article
Acute and chronic histopathologic changes in wild typeTLR-2-/-, TLR-4-/-, TLR-6-/-, TLR-9-/-, CD14-/-, and MyD-88-/- mice experimentally infected with Plasmodium chabaudi.
Ana Patrícia C. Silva,Soraia C. O. Rodrigues,Fernanda A. Merlo,Tatiane A. Paixão,Renato L. Santos +4 more
TL;DR: The findings suggest that acute and chronic phases of murine infection with P. chabaudi are characterized by distinct lesions, and that TLRs and MyD88 are not essential to promote these lesions during P. Chabaudi infection.
Journal ArticleDOI
Serologic and Cytokine Profiles of Children with Concurrent Cerebral Malaria and Severe Malarial Anemia Are Distinct from Other Subtypes of Severe Malaria.
Rafal S. Sobota,Abby R Goron,Andrea A. Berry,Jason A. Bailey,Drissa Coulibaly,Matthew Adams,Abdoulaye K. Kone,Bourema Kouriba,Ogobara K. Doumbo,Marcelo B. Sztein,Philip L. Felgner,Christopher V. Plowe,Kirsten E. Lyke,Mahamadou A. Thera,Mark A. Travassos +14 more
TL;DR: Comparison of levels of malaria-related cytokines revealed that children with the concurrent phenotype had elevated levels of interleukin (IL)-6, IL-8, and IL-10, which suggest that the pathophysiology of this severe subtype is unique and merits further investigation.
Dissertation
The expression of LFA-1, MAC-1 and ICAM-1 on leucocytes from patients with uncomplicated and those with complicated plasmodium falciparum malaria
TL;DR: This review focuses on malaria management and control strategies and immune mechanisms against pre-erythrocytic stages, as well as Innate immunity and Literature Review, which focuses on the latter.
References
More filters
Journal ArticleDOI
Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils.
TL;DR: It has been shown that CSa, formylmethionyl peptides, PAF, and LTB4 act via unrelated receptors, suggesting that neutrophil recruitment can result from the concerted action of multiple stimuli.
Journal ArticleDOI
Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs
Carl J. March,Bruce Mosley,Larsen Alf D,Douglas P. Cerretti,Gary Braedt,Virginia L. Price,Steven Gillis,Christopher S. Henney,Shirley R. Kronheim,Kenneth H. Grabstein,Paul J. Conlon,Thomas P. Hopp,David Cosman +12 more
TL;DR: Two distinct but distantly related complementary DNAs encoding proteins sharing human interleukin-1 (IL-1) activity (termed IL-lα and IL-1β), were isolated from a macrophage cDNA library.
Journal ArticleDOI
Biology of interleukin 1.
TL;DR: IL 1 is a highly inflammatory molecule and stimulates the production of arachidonic acid metabolites and acts synergistically with other cytokines, particularly tumor necrosis factor.
Journal Article
Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon.
Jordan S. Pober,Michael A. Gimbrone,Lynne A. Lapierre,D L Mendrick,Walter Fiers,Robert Rothlein,Timothy A. Springer +6 more
TL;DR: The authors used the quantitative binding of murine monoclonal antibodies to the surface of cultured human umbilical vein endothelial (HUVE) cells to study the responses of HUVE cells to three different immune mediators: interleukin 1 (IL 1), tumor necrosis factor (TNF), and immune interferon (IFN-gamma) antigens.