Journal ArticleDOI
Randomised double-blind placebo-controlled trial of SPf66 malaria vaccine in children in northwestern Thailand
François Nosten,Christine Luxemburger,Dennis E. Kyle,W. R. Ballou,Janet Wittes,E Wah,Tan Chongsuphajaisiddhi,Daniel M. Gordon,N J White,N J White,Jerald C. Sadoff,D. G. Heppner +11 more
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TLDR
It is concluded that SPf66 does not protect against clinical falciparum malaria and that further efficacy trials are not warranted, similar to earlier positive reports from South America and evidence of borderline efficacy from Tanzania.About:
This article is published in The Lancet.The article was published on 1996-09-14. It has received 173 citations till now. The article focuses on the topics: Malaria & Malaria vaccine.read more
Citations
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Journal ArticleDOI
Efficacy of the RTS,S/AS02A vaccine against Plasmodium falciparum infection and disease in young African children: randomised controlled trial
Pedro L. Alonso,Jahit Sacarlal,John J. Aponte,Amanda J. Leach,Eusebio Macete,Jessica Milman,Inacio Mandomando,Bart Spiessens,Caterina Guinovart,Mateu Espasa,Quique Bassat,Pedro Aide,Opokua Ofori-Anyinam,Margarita M. Navia,Sabine Corachan,Marc Ceuppens,Marie-Claude Dubois,Marie-Ange Demoitié,Filip Dubovsky,Clara Menendez,Nadia Tornieporth,W. Ripley Ballou,Ricardo Thompson,Joe Cohen +23 more
TL;DR: The results show development of an effective vaccine against malaria is feasible and the RTS,S/AS02A vaccine was safe, well tolerated, and immunogenic.
Journal ArticleDOI
Efficacy of RTS, S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in The Gambia: a randomised trial
Kalifa Bojang,Paul Milligan,Margaret Pinder,Laurence Vigneron,Ali Alloueche,Kent E. Kester,W. Ripley Ballou,David J. Conway,William H. H. Reece,Philip Gothard,Lawrence Yamuah,Martine Delchambre,Gerald Voss,Brian Greenwood,Adrian V. S. Hill,Keith P. W. J. McAdam,Nadia Tornieporth,Joe Cohen,Tom Doherty +18 more
TL;DR: RTS,S/AS02 is safe, immunogenic, and is the first pre-erythrocytic vaccine to show significant protection against natural P. falciparum infection in semi-immune adult men in The Gambia.
Journal ArticleDOI
Determinants of relapse periodicity in Plasmodium vivax malaria.
TL;DR: Evidence is presented that the proportion of patients who have successive relapses is relatively constant and that the factor which activates hypnozoites and leads to regular interval relapse in vivax malaria is the systemic febrile illness itself, which has important implications for the assessment of radical treatment efficacy and for malaria control and elimination.
Journal ArticleDOI
Malaria: current status of control, diagnosis, treatment, and a proposed agenda for research and development
Philippe J Guerin,Piero Olliaro,François Nosten,Pierre Druilhe,Ramanan Laxminarayan,Fred Binka,Wen L. Kilama,Nathan Ford,Nicholas J. White,Nicholas J. White +9 more
TL;DR: Research into the best methods of deploying and using existing approaches, particularly insecticide-treated mosquito nets, rapid methods of diagnosis, and artemisinin-based combination treatments should provide evidence on these approaches that would justify much-needed increases in global support for appropriate and effective malaria control.
Book
Design and Analysis of Vaccine Studies
TL;DR: In this article, the authors evaluate the effect of vaccination on post-infection outcomes and assess the indirect, total, and overall effects of the vaccine using household-based and independent households.
References
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Journal ArticleDOI
Bootstrap Methods for Standard Errors, Confidence Intervals, and Other Measures of Statistical Accuracy
Bradley Efron,Robert Tibshirani +1 more
TL;DR: The bootstrap is extended to other measures of statistical accuracy such as bias and prediction error, and to complicated data structures such as time series, censored data, and regression models.
Journal ArticleDOI
A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria
Manuel E. Patarroyo,Roberto Amador,Pedro Clavijo,Alberto Moreno,Fanny Guzman,Pedro Romero,Ricardo Tascon,Antonio Franco,Luis Angel Murillo,Gabriel Ponton,Gustavo Trujillo +10 more
TL;DR: Two polymeric synthetic hybrid proteins based on these peptides that delay or suppress the development of parasitaemia in immunized human volunteers are described.
Journal ArticleDOI
Randomised trial of efficacy of SPf66 vaccine against Plasmodium falciparum malaria in children in southern Tanzania.
Pedro L. Alonso,Thomas J. Smith,J. R. M. Armstrong Schellenberg,Honorati Masanja,S. Mwankusye,H. Urassa,I. Bastos de Azevedo,Chongela J,Kobero S,Clara Menendez,N. Hurt,Merlin C. Thomas,Eric Lyimo,N.A. Weiss,Richard J. Hayes,Andrew Y Kitua,M C Lopez,W. L. Kilama,T. Teuscher,Marcel Tanner +19 more
TL;DR: It is confirmed that SPf66 is safe, immunogenic and reduces the risk of clinical malaria among children exposed to intense P falciparum transmission.
Journal ArticleDOI
Opportunistic infections in AIDS in developed and developing countries.
TL;DR: The acquired immune deficiency syndrome (AIDS) is fundamentally the same disease in all parts of the world, but the prevalence of microorganisms in an environment governs the patterns of disease arising from reactivated latent infections, invading pathogens and opportunistic infections.
Journal ArticleDOI
Treatment Of Multidrug-Resistant Plasmodium Falciparum Malaria With 3-Day Artesunate-Mefloquine Combination
François Nosten,François Nosten,Christine Luxemburger,Christine Luxemburger,F O ter Kuile,F O ter Kuile,Charles J. Woodrow,Charles J. Woodrow,J. Pa Eh,J. Pa Eh,Tan Chongsuphajaisiddhi,Tan Chongsuphajaisiddhi,N J White,N J White +13 more
TL;DR: Artesunate (10mg/kg over 3 days) plus mefloquine (25 mg/kg) is currently the most effective treatment for falciparum malaria in this area of increasing meFLoquine resistance.
Related Papers (5)
Efficacy of RTS, S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in The Gambia: a randomised trial
Kalifa Bojang,Paul Milligan,Margaret Pinder,Laurence Vigneron,Ali Alloueche,Kent E. Kester,W. Ripley Ballou,David J. Conway,William H. H. Reece,Philip Gothard,Lawrence Yamuah,Martine Delchambre,Gerald Voss,Brian Greenwood,Adrian V. S. Hill,Keith P. W. J. McAdam,Nadia Tornieporth,Joe Cohen,Tom Doherty +18 more