Journal ArticleDOI
Randomized, Multicenter, Open-Label Study of Oxaliplatin Plus Fluorouracil/Leucovorin Versus Doxorubicin As Palliative Chemotherapy in Patients With Advanced Hepatocellular Carcinoma From Asia
Shukui Qin,Yuxian Bai,Ho Yeong Lim,Sumitra Thongprasert,Yee Chao,Jia Fan,Tsai-Shen Yang,Vajarabhongsa Bhudhisawasdi,Won Ki Kang,Yu Zhou,Jee Hyun Lee,Yan Sun +11 more
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TLDR
Although the study did not meet its primary end point, the trend toward improved OS with FOLFOX4, along with increased PFS and RR, suggests that this regimen may confer some benefit to Asian patients, but an OS benefit cannot be concluded from these data.Abstract:
Purpose To determine whether FOLFOX4 (infusional fluorouracil, leucovorin, and oxaliplatin) administered as palliative chemotherapy to patients with advanced hepatocellular carcinoma (HCC) provides a survival benefit and efficacy versus doxorubicin. Patients and Methods This multicenter, open-label, randomized, phase III study in mainland China, Taiwan, Korea, and Thailand involved 371 patients age 18 to 75 years who had locally advanced or metastatic HCC and were ineligible for curative resection or local treatment. They were randomly assigned at a ratio of one to one to receive either FOLFOX4 (n = 184) or doxorubicin (n = 187). The primary end point was overall survival (OS); secondary end points included progression-free survival (PFS), response rate (RR) by RECIST (version 1.0), and safety. Results At the prespecified final analysis, median OS was 6.40 months with FOLFOX4 (95% CI, 5.30 to 7.03) and 4.97 months with doxorubicin (95% CI, 4.23 to 6.03; P = .07; hazard ratio [HR], 0.80; 95% CI, 0.63 to 1....read more
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EASL-EORTC clinical practice guidelines : management of hepatocellular carcinoma
Peter R. Galle,Alejandro Forner,Josep M. Llovet,Vincenzo Mazzaferro,Fabio Piscaglia,Jean-Luc Raoul,Peter Schirmacher,Valérie Vilgrain +7 more
TL;DR: The following Clinical Practice Guidelines will give up-to-date advice for the clinical management of patients with hepatocellular carcinoma, as well as providing an in-depth review of all the relevant data leading to the conclusions herein.
Journal ArticleDOI
Molecular therapies and precision medicine for hepatocellular carcinoma
TL;DR: Treatment advances have been made in the past few years, and further advancements are expected in the near future, including biomarker-driven treatments and immunotherapies, as discussed in this Review.
Journal ArticleDOI
Advances in targeted therapies for hepatocellular carcinoma in the genomic era
TL;DR: The authors summarize the molecular concepts of progression, discuss the potential reasons for clinical trial failure and propose new concepts of drug development, which might lead to clinical implementation of emerging targeted agents.
Journal ArticleDOI
Guidelines for Diagnosis and Treatment of Primary Liver Cancer in China (2017 Edition).
Jian Zhou,Hui-Chuan Sun,Zheng Wang,Wen Ming Cong,Jian-Hua Wang,Meng Su Zeng,Jia Mei Yang,Ping Bie,Lianxin Liu,Tian Fu Wen,Guo Hong Han,Mao Qiang Wang,Rui Bao Liu,Li Gong Lu,Zheng Gang Ren,Minshan Chen,Zhao Chong Zeng,Ping Liang,Changhong Liang,Min Chen,Fu Hua Yan,Wen Ping Wang,Yuan Ji,Wen Wu Cheng,Chao Liu Dai,Wei-Dong Jia,Ya Ming Li,Ye Xiong Li,Jun Liang,Tian Shu Liu,Guo Yue Lv,Yi Lei Mao,Wei Xin Ren,Hong Cheng Shi,Wen Tao Wang,Xiaoying Wang,Bao Cai Xing,Jian Ming Xu,Jian Yong Yang,Ye Fa Yang,Sheng Long Ye,Zheng Yu Yin,Bo Heng Zhang,Shui Jun Zhang,Wei Ping Zhou,Ji Ye Zhu,Rong Liu,Ying Hong Shi,Yong Sheng Xiao,Zhi Dai,Gao Jun Teng,Jian Qiang Cai,Wei Lin Wang,Jia Hong Dong,Qiang Li,Feng Shen,Shu Kui Qin,Jia Fan +57 more
TL;DR: A guideline on the surveillance, diagnosis, staging, and treatment of HCC occurring in China is presented, and recommendations regarding patients with HCC in China are made to ensure optimum patient outcomes.
Journal ArticleDOI
Guidelines for the Diagnosis and Treatment of Hepatocellular Carcinoma (2019 Edition).
Jian Zhou,Hui-Chuan Sun,Zheng Wang,Wenming Cong,Jian-Hua Wang,Mengsu Zeng,Weiping Zhou,Ping Bie,Lianxin Liu,Tianfu Wen,Guohong Han,Maoqiang Wang,Ruibao Liu,Li Gong Lu,Zhengang Ren,Minshan Chen,Zhaochong Zeng,Ping Liang,Changhong Liang,Min Chen,Fuhua Yan,Wenping Wang,Yuan Ji,Jingping Yun,Dingfang Cai,Yongjun Chen,Wenwu Cheng,Shu-Qun Cheng,Chaoliu Dai,Wenzhi Guo,Baojin Hua,Xiaowu Huang,Wei-Dong Jia,Yaming Li,Yexiong Li,Jun Liang,Tianshu Liu,Guoyue Lv,Yilei Mao,Tao Peng,Wei Xin Ren,Hongcheng Shi,Guoming Shi,Kaishan Tao,Wentao Wang,Xiaoying Wang,Zhiming Wang,Bangde Xiang,Baocai Xing,Jian Ming Xu,Jiamei Yang,Jianyong Yang,Yefa Yang,Yunke Yang,Shenglong Ye,Zhengyu Yin,Bixiang Zhang,Boheng Zhang,Leida Zhang,Shuijun Zhang,Ti Zhang,Yongfu Zhao,Honggang Zheng,Jiye Zhu,Kangshun Zhu,Rong Liu,Yinghong Shi,Yongsheng Xiao,Zhi Dai,Gaojun Teng,Jianqiang Cai,Weilin Wang,Xiujun Cai,Qiang Li,Feng Shen,Shukui Qin,Jiahong Dong,Jia Fan +77 more
TL;DR: The new guidelines were endorsed and promulgated by the Bureau of Medical Administration of the National Health Commission of the People’s Republic of China in December 2019 and reflect the real-world situation in China regarding diagnosing and treating liver cancer in recent years.
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Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
Journal ArticleDOI
New Guidelines to Evaluate the Response to Treatment in Solid Tumors
Patrick Therasse,Susan G. Arbuck,Elizabeth Eisenhauer,Jantien Wanders,Richard Kaplan,Larry Rubinstein,Jaap Verweij,Martine Van Glabbeke,Allan T. van Oosterom,Michaele C. Christian,S. Gwyther +10 more
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Journal ArticleDOI
Sorafenib in Advanced Hepatocellular Carcinoma
Josep M. Llovet,Sergio Ricci,Vincenzo Mazzaferro,Philip Hilgard,Edward Gane,Jean-Frédéric Blanc,André Cosme de Oliveira,Armando Santoro,Jean-Luc Raoul,Alejandro Forner,Myron Schwartz,Camillo Porta,Stefan Zeuzem,Luigi Bolondi,Tim F. Greten,Peter R. Galle,Jean Francois Seitz,Ivan Borbath,Dieter Häussinger,Tom Giannaris,Minghua Shan,M. Moscovici,D. Voliotis,Jordi Bruix +23 more
TL;DR: In patients with advanced hepatocellular carcinoma, median survival and the time to radiologic progression were nearly 3 months longer for patients treated with sorafenib than for those given placebo.
Journal ArticleDOI
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial.
Ann-Lii Cheng,Yoon-Koo Kang,Zhendong Chen,Chao Jung Tsao,Shukui Qin,Jun Suk Kim,Rongcheng Luo,Jifeng Feng,Sheng-Long Ye,Tsai Sheng Yang,Jianming Xu,Yan Sun,Houjie Liang,Jiwei Liu,Jiejun Wang,Won Young Tak,Hongming Pan,Karin Burock,Jessie Zou,D. Voliotis,Zhongzhen Guan +20 more
TL;DR: Sorafenib is effective for the treatment of advanced hepatocellular carcinoma in patients from the Asia-Pacific region, and is well tolerated.
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