Randomized Trial of Omalizumab (Anti-IgE) for Asthma in Inner-City Children
William W. Busse,Wayne J. Morgan,Peter J. Gergen,Herman Mitchell,James E. Gern,Andrew H. Liu,Rebecca S. Gruchalla,Meyer Kattan,Stephen J. Teach,Jacqueline A. Pongracic,James F. Chmiel,Suzanne Steinbach,Agustin Calatroni,Alkis Togias,Katherine M. Thompson,Stanley J. Szefler,Christine A. Sorkness +16 more
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TLDR
When added to a regimen of guidelines-based therapy for inner-city children, adolescents, and young adults, omalizumab further improved asthma control, nearly eliminated seasonal peaks in exacerbations, and reduced the need for other medications to control asthma.Abstract:
Among 419 participants who underwent randomization (at which point 73% had moderate or severe disease), omalizumab as compared with placebo significantly reduced the number of days with asthma symptoms, from 1.96 to 1.48 days per 2-week interval, a 24.5% decrease (P<0.001). Similarly, omalizumab significantly reduced the proportion of participants who had one or more exacerbations from 48.8 to 30.3% (P<0.001). Improvements occurred with omalizumab despite reductions in the use of inhaled glucocorticoids and long-acting beta-agonists. Conclusions When added to a regimen of guidelines-based therapy for inner-city children, adolescents, and young adults, omalizumab further improved asthma control, nearly eliminated seasonal peaks in exacerbations, and reduced the need for other medications to control asthma. (Funded by the National Institute of Allergy and Infectious Diseases and Novartis; ClinicalTrials.gov number, NCT00377572.)read more
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International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Kian Fan Chung,Sally E. Wenzel,Jan Brozek,Andrew Bush,Mario Castro,Peter J. Sterk,Ian M. Adcock,Eric D. Bateman,Elisabeth H. Bel,Eugene R. Bleecker,Louis-Philippe Boulet,Christopher E. Brightling,Pascal Chanez,Sven-Erik Dahlén,Ratko Djukanovic,Urs Frey,Mina Gaga,Peter G. Gibson,Qutayba Hamid,Nizar N. Jajour,Thais Mauad,Ronald L. Sorkness,W. Gerald Teague +22 more
TL;DR: Recommendations and guidelines on the evaluation and treatment of severe asthma in children and adults and coordinated research efforts for improved phenotyping will provide safe and effective biomarker-driven approaches to severe asthma therapy are provided.
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Asthma phenotypes: the evolution from clinical to molecular approaches
TL;DR: Ongoing studies of large-scale, molecularly and genetically focused and extensively clinically characterized cohorts of asthma should enhance the ability to molecularly understand these phenotypes and lead to more targeted and personalized approaches to asthma therapy.
Journal ArticleDOI
Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study.
Nicola A. Hanania,Sally E. Wenzel,Karin Rosén,Hsin-Ju Hsieh,Sofia Mosesova,David F. Choy,Preeti Lal,Joseph R. Arron,Jeffrey M. Harris,William W. Busse +9 more
TL;DR: The difference in exacerbation frequency between omalizumab and placebo was greatest in the three high-biomarker subgroups, probably associated with the greater risk for exacerbations in high subgroups.
Journal ArticleDOI
After asthma: redefining airways diseases
Ian D. Pavord,Richard Beasley,Alvar Agusti,Gary P. Anderson,Elisabeth H. Bel,Guy Brusselle,Guy Brusselle,Paul Cullinan,Adnan Custovic,Francine M. Ducharme,John V. Fahy,Urs Frey,Peter G. Gibson,Peter G. Gibson,Liam G Heaney,Patrick G. Holt,Marc Humbert,Marc Humbert,Clare M. Lloyd,Guy B. Marks,Fernando D. Martinez,Peter D. Sly,Erika von Mutius,Sally E. Wenzel,Heather J. Zar,Andrew Bush +25 more
TL;DR: The only way to make progress in the future is to be much more clear about the meaning of the labels used for asthma and to acknowledge the assumptions associated with them, which are believed to be the most important causes of the stagnation in key clinical outcomes observed in the past 10 years.
Journal ArticleDOI
Omalizumab for asthma in adults and children.
Rebecca Normansell,Samantha Walker,Stephen J Milan,E. Haydn Walters,Parameswaran Nair,Parameswaran Nair +5 more
TL;DR: An updated review of NICE guidance recommends omalizumab for use as add-on therapy in adults and children over six years of age with inadequately controlled severe persistent allergic IgE-mediated asthma who require continuous or frequent treatment with oral corticosteroids and a main focus of the updated review is subcutaneous administration, as this route is currently used in clinical practice.
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