Journal ArticleDOI
Recombinant polyoma--vaccinia viruses: T antigen expression vectors and anti-tumor immunization agents.
Philippe Clertant,Marie Paule Kieny,J P Lecocq,Ikram Guizani,Pierre Chambon,François Cuzin,Richard Lathe +6 more
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TLDR
No circulating antibodies directed against PyV large-T or middle-T antigens were detected in animals vaccinated with the large-tumor viruses, suggesting that rejection may be due to a cell-mediated immune response.About:
This article is published in Biochimie.The article was published on 1988-08-01. It has received 5 citations till now. The article focuses on the topics: Orthopoxvirus & Antigen.read more
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Journal ArticleDOI
Immunization against human papillomavirus type 16 tumor cells with recombinant vaccinia viruses expressing E6 and E7.
TL;DR: It is reported that inoculation of rats with vaccinia recombinants expressing E6 or E7 retarded or prevented tumor development in a proportion of animals challenged by subcutaneous seeding of tumor cells whereas the recombinant expressing E5 was inactive.
Book ChapterDOI
Recombinant vaccinia viruses as vectors for studying T lymphocyte specificity and function.
J. R. Bennink,J. W. Yewdell +1 more
TL;DR: The ability of VV to infect mice and a broad variety of mouse and human cell lines of diverse lineages that can function as APCs make them ideal vectors for studies of T lymphocytes.
Journal ArticleDOI
Vaccinia recombinants expressing early bovine papilloma virus (BPV1) proteins: retardation of BPV1 tumour development.
Guerrino Meneguzzi,Marie Paule Kieny,Jean-Pierre Lecocq,Pierre Chambon,François Cuzin,Richard Lathe +5 more
TL;DR: It was previously demonstrated that animals inoculated with live vaccinia recombinants expressing early proteins of polyoma virus resist challenge with polyoma-tumour cells, and this approach has been extended to the development of a vaccine against papillomavirus-transformed cells.
Journal ArticleDOI
The next wave of recombinant and synthetic anticancer vaccines
TL;DR: The identification of tumor-associated antigens (TAA) recognized by T lymphocytes makes the development of antigen-specific synthetic and recombinant vaccines possible and the ultimate goal, the treatment of established cancer, is now being realized in animal models.
Journal ArticleDOI
Vaccination against polyoma virus (PyV) tumors using vaccinia-PyV recombinants: a major tumor-specific transplantation antigen (TSTA) epitope resides within the C-terminal segment of middle-T protein.
Marie Paule Kieny,C. Gautier,Catherine Tomasetto,I. Kuhn,M. Hareuveni,Philippe Clertant,Richard Lathe,Richard Lathe +7 more
TL;DR: In the two experiments performed, tumor growth enhancement rather than retardation was observed in VVpyLT‐vaccinated animals receiving PyV‐LT challenge tumor cells, indicating the presence of a major TSTA epitope within the unique C‐terminal region of MT.
References
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Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
A short amino acid sequence able to specify nuclear location
TL;DR: By reducing the size of the transposed sequence, it is concluded that Pro-Lys- lys- Lys-Arg-L Lys-Val can act as a nuclear location signal and may represent a prototype of similar sequences in other nuclear proteins.
Journal ArticleDOI
Immunity to methylcholanthrene-induced sarcomas.
Richmond T. Prehn,Joan M. Main +1 more
Journal ArticleDOI
General method for production and selection of infectious vaccinia virus recombinants expressing foreign genes.
TL;DR: The production and selection of infectious vaccinia virus recombinants expressing foreign genes was facilitated by the construction of plasmid vectors and Infectious recombinant viruses expressing the procaryotic enzyme chloramphenicol acetyltransferase were constructed to optimize the system.