Journal ArticleDOI
Reduced pathogenicity of fructose-1,6-bisphosphatase deficient Leishmania donovani and its use as an attenuated strain to induce protective immunogenicity.
Savita Saini,Ayan Kumar Ghosh,Sushmita Das,Ruby Singh,Kumar Abhishek,Sudha Verma,Ajay Kumar,Abhishek Mandal,Bidyut Purkait,Kislay K. Sinha,Pradeep Das +10 more
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TLDR
It is proposed that Δfbpase L. donovani parasites can be a live attenuated vaccine candidate for VL and a good model to understand the correlatives of protection in visceral leishmaniasis.About:
This article is published in Vaccine.The article was published on 2018-02-21. It has received 3 citations till now. The article focuses on the topics: Leishmania donovani & Attenuated vaccine.read more
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An immunoinformatic approach driven by experimental proteomics: in silico design of a subunit candidate vaccine targeting secretory proteins of Leishmania donovani amastigotes
Anik Ashfaq Khan,Jenifar Quaiyum Ami,Khaledul Faisal,Rajashree Chowdhury,Prakash Ghosh,Faria Hossain,Ahmed Abd El Wahed,Dinesh Mondal +7 more
TL;DR: The methodological approach and results from this study could facilitate more informed screening and selection of candidate antigenic proteins for entry into vaccine production pipeline in future to control human VL.
Journal ArticleDOI
Live attenuated vaccines, a favorable strategy to provide long-term immunity against protozoan diseases
Lv Guohua,Mona Ali +1 more
TL;DR: Live attenuated vaccines (LAVs) against malaria, Chagas disease and leishmaniasis have been developed and evaluated in clinical trials as mentioned in this paper , with the success of irradiated or genetically attenuated sporozoites against malaria.
Journal ArticleDOI
Next-Generation Leishmanization: Revisiting Molecular Targets for Selecting Genetically Engineered Live-Attenuated Leishmania
TL;DR: In this paper , the authors revisited molecular targets associated with the selection of live-attenuated leishmanization vaccine strains, discussed their function, their limiting factors and the ideal candidate for the next generation of genetically engineered liveattenuated Leishmania vaccines.
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IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.
David Fiorentino,Albert Zlotnik,Pedro L. Vieira,Tim R. Mosmann,M Howard,Kevin W. Moore,Anne O'Garra +6 more
TL;DR: IL-10 may inhibit macrophage accessory cell function which is independent of TCR-class II MHC interactions, as well as inhibits IL-2-induced IFN-gamma production by Th1 cells in an Ag-free system requiring only the presence of accessory cells.
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Phenotypic and functional features of human Th17 cells.
Francesco Annunziato,Lorenzo Cosmi,Veronica Santarlasci,Laura Maggi,Francesco Liotta,Benedetta Mazzinghi,Eliana Parente,Lucia Filì,Simona Ferri,Francesca Frosali,Francesco Giudici,Paola Romagnani,Paola Parronchi,Francesco Tonelli,Enrico Maggi,Sergio Romagnani +15 more
TL;DR: The demonstration of selective markers for human Th17 cells may help to understand their pathogenic role, and the identification of a subset of cells sharing features of both Th1 and Th17 may raise new issues concerning developmental and/or functional relationships between Th17 and Th1.
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Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major.
Patricia A. Darrah,Dipti T. Patel,Paula M De Luca,Ross W. B. Lindsay,Dylan F. Davey,Barbara J. Flynn,Søren T. Hoff,Peter Andersen,Steven G. Reed,Sheldon L. Morris,Mario Roederer,Robert A. Seder +11 more
TL;DR: The quality of a CD4+ T-cell cytokine response can be a crucial determinant in whether a vaccine is protective, and may provide a new and useful prospective immune correlate of protection for vaccines based on T-helper type 1 (TH1) cells.
Journal ArticleDOI
Leishmaniasis: complexity at the host–pathogen interface
Paul M. Kaye,Phillip Scott +1 more
TL;DR: Recent evidence suggests that each host–pathogen combination evokes different solutions to the problems of parasite establishment, survival and persistence in Leishmania spp.
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The Role of Interleukin (IL)-10 in the Persistence of Leishmania major in the Skin after Healing and the Therapeutic Potential of Anti–IL-10 Receptor Antibody for Sterile Cure
Yasmine Belkaid,Karl F. Hoffmann,Susana Mendez,Shaden Kamhawi,Mark C. Udey,Tom A. Wynn,David L. Sacks +6 more
TL;DR: A novel therapeutic approach to eliminate latency, infection reservoirs, and the risk of reactivation disease is suggested as sterile cure was achieved in IL-10–deficient and IL-4/IL-10 double-deficient mice.