Journal ArticleDOI
Regenerating functional myocardium: Improved performance after skeletal myoblast transplantation
Doris A. Taylor,Atkins Bz,P Hungspreugs,T R Jones,Mary C. Reedy,Kelley A. Hutcheson,Donald D. Glower,William E. Kraus +7 more
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TLDR
In rabbits in which myoblasts were incorporated, myocardial performance was improved and the ability to regeneratefunctioning muscle after autologous myoblast transplantation could have a important effect on patients after acuteMyocardial infarction.Abstract:
The adult heart lacks reserve cardiocytes and cannot regenerate. Therefore, a large acute myocardial infarction often develops into congestive heart failure. To attempt to prevent this progression, we transplanted skeletal myoblasts into cryoinfarcted myocardium of the same rabbits (autologous transfer), monitored cardiac function in vivo for two to six weeks and examined serial sections of the hearts by light and electron microscopy. Islands of different sizes comprising elongated, striated cells that retained characteristics of both skeletal and cardiac cells were found in the cryoinfarct. In rabbits in which myoblasts were incorporated, myocardial performance was improved. The ability to regenerate functioning muscle after autologous myoblast transplantation could have a important effect on patients after acute myocardial infarction.read more
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Human Mesenchymal Stem Cells Differentiate to a Cardiomyocyte Phenotype in the Adult Murine Heart
TL;DR: The persistence of the engrafted hMSCs and their in situ differentiation in the heart may represent the basis for using these adult stem cells for cellular cardiomyoplasty.
Journal ArticleDOI
Mobilized bone marrow cells repair the infarcted heart, improving function and survival
Donald Orlic,Jan Kajstura,Stefano Chimenti,Federica Limana,Igor Jakoniuk,Federico Quaini,Bernardo Nadal-Ginard,David M. Bodine,Annarosa Leri,Piero Anversa +9 more
TL;DR: In this article, the authors demonstrate that transplanting primitive bone marrow cells (BMC) into the border zone of acute myocardial infarcts resulted in a significant degree of tissue regeneration 27 days later.
Journal ArticleDOI
Repair of Infarcted Myocardium by Autologous Intracoronary Mononuclear Bone Marrow Cell Transplantation in Humans
Bodo E. Strauer,Michael A. Brehm,Tobias Zeus,Matthias Köstering,Anna Hernandez,Rüdiger V. Sorg,Gesine Kögler,Peter Wernet +7 more
TL;DR: Ten patients who were treated by intracoronary transplantation of autologous, mononuclear bone marrow cells (BMCs) in addition to standard therapy after MI found that the infarct region had decreased significantly within the cell therapy group and was also significantly smaller compared with the standard therapy group.
Journal ArticleDOI
Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells
Kathyjo A. Jackson,Susan M. Majka,Hongyu Wang,Jennifer Pocius,Craig J. Hartley,Mark W. Majesky,Mark L. Entman,Lloyd H. Michael,Karen K. Hirschi,Margaret A. Goodell +9 more
TL;DR: The results demonstrate the cardiomyogenic potential of hematopoietic stem cells and suggest a therapeutic strategy that eventually could benefit patients with myocardial infarction.
Journal ArticleDOI
Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes.
Izhak Kehat,Dorit Kenyagin-Karsenti,Mirit Snir,Hana Segev,Michal Amit,Amira Gepstein,Erella Livne,Ofer Binah,Joseph Itskovitz-Eldor,Lior Gepstein +9 more
TL;DR: The human ES cell--derived cardiomyocytes displayed structural and functional properties of early-stage cardiomers, which may have significant impact on the study of early human cardiac differentiation, functional genomics, pharmacological testing, cell therapy, and tissue engineering.
References
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TL;DR: A simple genetic manipulation can be used to select essentially pure cultures of cardiomyocytes from differentiating ES cells that are suitable for the formation of intracardiac grafts, and should be applicable to all ES-derived cell lineages.
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Cellular cardiomyoplasty: Myocardial regeneration with satellite cell implantation
TL;DR: The hypothesis that skeletal muscle satellite cells implanted into injured myocardium can differentiate into cardiac muscle fibers and thus repair damaged heart muscle is tested and data are consistent with the hypothesis of milieu-influenced differentiation of satellite cells into cardiac-like muscle cells.
Journal ArticleDOI
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