Journal ArticleDOI
Regulation of innate and adaptive immunity by Notch
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The aim of this Review is to summarize the current status of immune regulation by Notch, and to provide multiple avenues for therapeutic intervention in disease.Abstract:
Coordinated function of the innate and adaptive arms of the immune system in vertebrates is essential to promote protective immunity and to avoid immunopathology. The Notch signalling pathway, which was originally identified as a pleiotropic mediator of cell fate in invertebrates, has recently emerged as an important regulator of immune cell development and function. Notch was initially shown to be a key determinant of cell-lineage commitment in developing lymphocytes, but it is now known to control the homeostasis of several innate cell populations. Moreover, the roles of Notch in adaptive immunity have expanded to include the regulation of T cell differentiation and function. The aim of this Review is to summarize the current status of immune regulation by Notch. A better understanding of Notch function in both innate and adaptive immunity will hopefully provide multiple avenues for therapeutic intervention in disease.read more
Citations
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From Stress to Inflammation and Major Depressive Disorder: A Social Signal Transduction Theory of Depression
TL;DR: A biologically plausible, multilevel theory is proposed that describes neural, physiologic, molecular, and genomic mechanisms that link experiences of social-environmental stress with internal biological processes that drive depression pathogenesis and may shed light on several important questions including how depression develops, why it frequently recurs, and why it is strongly predicted by early life stress.
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The cellular and molecular origin of tumor-associated macrophages.
Ruth A. Franklin,Will Liao,Abira Sarkar,Myoungjoo V. Kim,Myoungjoo V. Kim,Michael R. Bivona,Kang Liu,Eric G. Pamer,Ming O. Li +8 more
TL;DR: In mice, mammary tumor growth induces the accumulation of tumor-associated macrophage that are phenotypically and functionally distinct from mammary tissue macrophages, which reveal the ontogeny of TAMs and a discrete tumor-elicited inflammatory response, which may provide new opportunities for cancer immunotherapy.
Journal ArticleDOI
Notch Signaling in Development, Tissue Homeostasis, and Disease
Chris Siebel,Urban Lendahl +1 more
TL;DR: The current understanding of how Notch signaling can become derailed, either by direct mutations or by aberrant regulation, and the expanding spectrum of diseases and cancers that is a consequence of Notch dysregulation are discussed.
Journal ArticleDOI
Debunking the Myth of Exercise-induced Immune Suppression: Redefining the Impact of Exercise on Immunological Health Across the Lifespan.
John Campbell,James E. Turner +1 more
TL;DR: Evidence that frequent exercise enhances—rather than suppresses—immune competency is provided, and key findings from human vaccination studies which show heightened responses to bacterial and viral antigens following bouts of exercise are highlighted.
Journal ArticleDOI
Notch Signaling in the Tumor Microenvironment.
Olivier Meurette,Patrick Mehlen +1 more
TL;DR: How Notch signaling takes an important part in regulating the crosstalk between the different compartments of the TME is discussed and the consequences of the Notch-TME involvement from a therapeutic perspective are addressed.
References
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Journal Article
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
TL;DR: A panel of antigen-specific mouse helper T cell clones was characterized according to patterns of lymphokine activity production, and two types of T cell were distinguished.
Journal ArticleDOI
Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3
Wanjun Chen,Wenwen Jin,Neil J. Hardegen,Ke Jian Lei,Li Li,Nancy J. Marinos,George McGrady,Sharon M. Wahl +7 more
TL;DR: Novel evidence is presented that conversion of naive peripheral CD4+CD25− T cells into anergic/suppressor cells that are CD25+, CD45RB−/low and intracellular CTLA-4+ can be achieved through costimulation with T cell receptors (TCRs) and transforming growth factor β (TGF-β).
Journal ArticleDOI
Interleukin 17–producing CD4 + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Laurie E. Harrington,Robin D. Hatton,Paul R. Mangan,Henrietta Turner,Theresa L. Murphy,Kenneth M. Murphy,Casey T. Weaver +6 more
TL;DR: Findings provide a basis for understanding how inhibition of IFN-γ signaling enhances development of pathogenic TH-17 effector cells that can exacerbate autoimmunity.
Journal ArticleDOI
TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-Producing T cells
Marc Veldhoen,Richard J. Hocking,Christopher J. Atkins,Richard M. Locksley,Brigitta Stockinger +4 more
TL;DR: The data indicate that, in the presence of IL-6, TGFbeta1 subverts Th1 and Th2 differentiation for the generation ofIL-17-producing T cells.
Journal ArticleDOI
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
TL;DR: This Review highlights recent studies in Notch signaling that reveal new molecular details about the regulation of ligand-mediated receptor activation, receptor proteolysis, and target selection.
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