Reversible Inactivation of Protein-tyrosine Phosphatase 1B in A431 Cells Stimulated with Epidermal Growth Factor
Reads0
Chats0
TLDR
The results indicate that the activation of a receptor tyrosine kinase by binding of the corresponding growth factor may not be sufficient to increase the steady state level of protein tyrosines phosphorylation in cells and that concurrent inhibition of protein-tyrosine phosphatases by H2O2 might also be required.About:
This article is published in Journal of Biological Chemistry.The article was published on 1998-06-19 and is currently open access. It has received 955 citations till now. The article focuses on the topics: Tyrosine phosphorylation & Iodoacetic acid.read more
Citations
More filters
Journal ArticleDOI
Oxidants, oxidative stress and the biology of ageing.
Toren Finkel,Nikki J. Holbrook +1 more
TL;DR: Evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span is reviewed.
Journal ArticleDOI
Cell signaling by receptor-tyrosine kinases
TL;DR: Understanding of the complex signaling networks downstream from RTKs and how alterations in these networks are translated into cellular responses provides an important context for therapeutically countering the effects of pathogenic RTK mutations in cancer and other diseases.
Journal ArticleDOI
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Karen Bedard,Karl-Heinz Krause +1 more
TL;DR: This review summarizes the current state of knowledge of the functions of NOX enzymes in physiology and pathology.
Journal ArticleDOI
ROS Function in Redox Signaling and Oxidative Stress
TL;DR: It is argued that redox biology, rather than oxidative stress, underlies physiological and pathological conditions.
Journal ArticleDOI
Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
TL;DR: This review focuses on the molecular mechanisms through which ROS directly interact with critical signaling molecules to initiate signaling in a broad variety of cellular processes, such as proliferation and survival, ROS homeostasis and antioxidant gene regulation, mitochondrial oxidative stress, apoptosis, and aging.
References
More filters
Journal ArticleDOI
Tissue sulfhydryl groups
TL;DR: A water-soluble (at pH 8) aromatic disulfide [5,5′-dithiobis(2-nitrobenzoic acid] has been synthesized and shown to be useful for determination of sulfhydryl groups.
Journal ArticleDOI
Requirement for Generation of H2O2 for Platelet-Derived Growth Factor Signal Transduction
TL;DR: The results suggest that H2O2 may act as a signal-transducing molecule, and they suggest a potential mechanism for the cardioprotective effects of antioxidants.
Journal ArticleDOI
Oxidized redox state of glutathione in the endoplasmic reticulum
TL;DR: Results suggest that the demonstrated preferential transport of GSSG compared to GSH into the ER lumen may contribute to this redox compartmentation.
Journal ArticleDOI
Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts
Kaikobad Irani,Yong Xia,Jay L. Zweier,Steven J. Sollott,Channing J. Der,Eric R. Fearon,Maitrayee Sundaresan,Toren Finkel,Pascal J. Goldschmidt-Clermont +8 more
TL;DR: H-RasV12-induced transformation can lead to the production of ·O2− through one or more pathways involving a flavoprotein and Rac1, suggesting a possible mechanism for the effects of antioxidants against Ras-induced cellular transformation.
Journal ArticleDOI
Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide ROLE IN EGF RECEPTOR-MEDIATED TYROSINE PHOSPHORYLATION
TL;DR: In this paper, the role of reactive oxygen species (ROS) in epidermal growth factor (EGF) signaling was investigated, and the dependence of H2O2 production on the intrinsic tyrosine kinase activity of the EGF receptor and the autophosphorylation sites located in its COOH-terminal tail was investigated.