Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism.
Amna Sirelkhatim,Shahrom Mahmud,Azman Seeni,Noor Haida Mohamad Kaus,Ling Chuo Ann,Siti Khadijah Mohd Bakhori,Habsah Hasan,Dasmawati Mohamad +7 more
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This review covered ZnO-NPs antibacterial activity including testing methods, impact of UV illumination,ZnO particle properties (size, concentration, morphology, and defects), particle surface modification, and minimum inhibitory concentration.Abstract:
Antibacterial activity of zinc oxide nanoparticles (ZnO-NPs) has received significant interest worldwide particularly by the implementation of nanotechnology to synthesize particles in the nanometer region. Many microorganisms exist in the range from hundreds of nanometers to tens of micrometers. ZnO-NPs exhibit attractive antibacterial properties due to increased specific surface area as the reduced particle size leading to enhanced particle surface reactivity. ZnO is a bio-safe material that possesses photo-oxidizing and photocatalysis impacts on chemical and biological species. This review covered ZnO-NPs antibacterial activity including testing methods, impact of UV illumination, ZnO particle properties (size, concentration, morphology, and defects), particle surface modification, and minimum inhibitory concentration. Particular emphasize was given to bactericidal and bacteriostatic mechanisms with focus on generation of reactive oxygen species (ROS) including hydrogen peroxide (H2O2), OH− (hydroxyl radicals), and O2 −2 (peroxide). ROS has been a major factor for several mechanisms including cell wall damage due to ZnO-localized interaction, enhanced membrane permeability, internalization of NPs due to loss of proton motive force and uptake of toxic dissolved zinc ions. These have led to mitochondria weakness, intracellular outflow, and release in gene expression of oxidative stress which caused eventual cell growth inhibition and cell death. In some cases, enhanced antibacterial activity can be attributed to surface defects on ZnO abrasive surface texture. One functional application of the ZnO antibacterial bioactivity was discussed in food packaging industry where ZnO-NPs are used as an antibacterial agent toward foodborne diseases. Proper incorporation of ZnO-NPs into packaging materials can cause interaction with foodborne pathogens, thereby releasing NPs onto food surface where they come in contact with bad bacteria and cause the bacterial death and/or inhibition.read more
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A Review on Chitosan's Uses as Biomaterial: Tissue Engineering, Drug Delivery Systems and Cancer Treatment.
Rayssa de Sousa Victor,Adillys Marcelo da Cunha Santos,Bianca Viana de Sousa,Gelmires de Araújo Neves,Lisiane Navarro de Lima Santana,Romualdo Rodrigues Menezes +5 more
TL;DR: The most relevant and new information about this polysaccharide-based biomaterial’s applications in distinct fields are presented and also the ability of chitosan and its various derivatives to selectively permeate through the cancer cell membranes and exhibit anticancer activity is presented.
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Light-Controlled Growth Factors Release on Tetrapodal ZnO-Incorporated 3D-Printed Hydrogels for Developing Smart Wound Scaffold
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A one-step sonochemical synthesis of stable ZnO–PVA nanocolloid as a potential biocidal agent
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Chitosan-based hydrogel wound dressings with electrochemically incorporated silver nanoparticles – In vitro study
Katarina Nešović,Ana Janković,Tamara Radetić,Maja Vukašinović-Sekulić,Vesna Kojić,Ljiljana Živković,Aleksandra A. Perić-Grujić,Kyong Yop Rhee,Vesna Mišković-Stanković,Vesna Mišković-Stanković +9 more
TL;DR: In this paper, a facile path for the preparation of wound dressing materials with improved characteristics based on biocompatible chitosan and poly(vinyl alcohol) hydrogels with embedded silver nanoparticles (AgNPs) as a potent antimicrobial agent.
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