Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism.
Amna Sirelkhatim,Shahrom Mahmud,Azman Seeni,Noor Haida Mohamad Kaus,Ling Chuo Ann,Siti Khadijah Mohd Bakhori,Habsah Hasan,Dasmawati Mohamad +7 more
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TLDR
This review covered ZnO-NPs antibacterial activity including testing methods, impact of UV illumination,ZnO particle properties (size, concentration, morphology, and defects), particle surface modification, and minimum inhibitory concentration.Abstract:
Antibacterial activity of zinc oxide nanoparticles (ZnO-NPs) has received significant interest worldwide particularly by the implementation of nanotechnology to synthesize particles in the nanometer region. Many microorganisms exist in the range from hundreds of nanometers to tens of micrometers. ZnO-NPs exhibit attractive antibacterial properties due to increased specific surface area as the reduced particle size leading to enhanced particle surface reactivity. ZnO is a bio-safe material that possesses photo-oxidizing and photocatalysis impacts on chemical and biological species. This review covered ZnO-NPs antibacterial activity including testing methods, impact of UV illumination, ZnO particle properties (size, concentration, morphology, and defects), particle surface modification, and minimum inhibitory concentration. Particular emphasize was given to bactericidal and bacteriostatic mechanisms with focus on generation of reactive oxygen species (ROS) including hydrogen peroxide (H2O2), OH− (hydroxyl radicals), and O2 −2 (peroxide). ROS has been a major factor for several mechanisms including cell wall damage due to ZnO-localized interaction, enhanced membrane permeability, internalization of NPs due to loss of proton motive force and uptake of toxic dissolved zinc ions. These have led to mitochondria weakness, intracellular outflow, and release in gene expression of oxidative stress which caused eventual cell growth inhibition and cell death. In some cases, enhanced antibacterial activity can be attributed to surface defects on ZnO abrasive surface texture. One functional application of the ZnO antibacterial bioactivity was discussed in food packaging industry where ZnO-NPs are used as an antibacterial agent toward foodborne diseases. Proper incorporation of ZnO-NPs into packaging materials can cause interaction with foodborne pathogens, thereby releasing NPs onto food surface where they come in contact with bad bacteria and cause the bacterial death and/or inhibition.read more
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Nanoparticles as antimicrobial and antiviral agents: A literature-based perspective study.
Shabnam Sharmin,Md. Mizanur Rahaman,Chandan Kumar Sarkar,Olubunmi Atolani,Mohammad Torequl Islam,Oluyomi Stephen Adeyemi +5 more
TL;DR: In this article, the antibacterial, antifungal, and antiviral potential of nanoparticles with their probable mechanism of action is discussed, and various materials have been used for the synthesis of nanoparticle with unique properties channelised to meet specific therapeutic requirement.
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A review: zinc oxide nanoparticles - friends or enemies?
Agnieszka Czyżowska,Anna Barbasz +1 more
TL;DR: Whether the toxicity of zinc oxide nanoparticles found in numerous test models is a real threat to humans and plants is considered, in a manner dependent on the concentration and a method of synthesis.
Journal ArticleDOI
Synthesis, characterization, in vitro biocompatibility and antibacterial properties study of nanocomposite materials based on hydroxyapatite-biphasic ZnO micro- and nanoparticles embedded in Alginate matrix
Amanzhol Turlybekuly,Alexander D. Pogrebnjak,L. F. Sukhodub,L. B. Sukhodub,Aida Kistaubayeva,Irina Savitskaya,D. H. Shokatayeva,O. V. Bondar,Zh.K. Shaimardanov,S. V. Plotnikov,B.H. Shaimardanova,Ilya Digel +11 more
TL;DR: The studied composite demonstrate a pronounced antibacterial activity due to the incorporation of ZnO particles into sodium alginate and moistened powder of hydroxyapatite, and both forms of HA-ZnO (suspension) and HA-Alg-ZNO (beads) are biocompatible.
Journal ArticleDOI
Controlled degradability of PCL-ZnO nanofibrous scaffolds for bone tissue engineering and their antibacterial activity.
Betiana Felice,Maria Alejandra Sanchez,María Cecilia Socci,Luciano D. Sappia,María Inés Gómez,María Karina Cruz,Carmelo Jose Felice,Mercè Martí,María Isabel Pividori,Gabriela Simonelli,Andrea Paola Rodriguez +10 more
TL;DR: This work suggests that PCL:ZnO scaffolds may be promising and competitive short-, mid- and long-term resorption systems against current clinical solutions for bone tissue regeneration.
Journal ArticleDOI
ZnO Nanopillar Coated Surfaces with Substrate-Dependent Superbactericidal Property
TL;DR: Mechanistic study shows that the nanostructure surface kills adhered microbial cells by rupturing the cell wall, while superoxide released from the ZnO coating with electrons donated from zinc via theZn/ZnO interface rather than photoirritation is responsible for the superior remote killing.
References
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Zinc oxide nanostructures: growth, properties and applications
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