Journal ArticleDOI
Revisiting the fluid mosaic model of membranes.
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This article is published in Science.The article was published on 1995-06-09. It has received 469 citations till now. The article focuses on the topics: Fluid mosaic model & Membrane.read more
Citations
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GPI-anchored proteins are organized in submicron domains at the cell surface
Rajat Varma,Satyajit Mayor +1 more
TL;DR: The results indicate that lipid-linked proteins are organized in cholesterol-dependent submicron-sized domains, which are likely to be less than 70 nm in diameter and are disrupted by removal of cellular cholesterol.
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Lipid rafts bringing order to chaos
TL;DR: The role of lipid rafts in signaling via receptor tyrosine kinases and G protein-coupled receptors is summarized and studies that have helped to elucidate the role are summarized.
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Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation.
Martha Triantafilou,Kensuke Miyake,Douglas T. Golenbock,Douglas T. Golenbock,Kathy Triantafilou +4 more
TL;DR: The results suggest that the entire bacterial recognition system is based around the ligation of CD14 by bacterial components and the recruitment of multiple signalling molecules, such as hsp70, hsp90, CXCR4, GDF5 and TLR4, within the lipid rafts.
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Single-molecule microscopy on model membranes reveals anomalous diffusion
TL;DR: A new type of analysis for tracking data by making use of the probability distribution of square displacements is presented, which characterizes the so-called immobile fraction often found in FRAP experiments.
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The Fluid—Mosaic Model of Membrane Structure: Still relevant to understanding the structure, function and dynamics of biological membranes after more than 40 years
TL;DR: In updated versions of the model more emphasis has been placed on the mosaic nature of the macrostructure of cellular membranes where many protein and lipid components are limited in their rotational and lateral motilities in the membrane plane, especially in their natural states.
References
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Journal ArticleDOI
The fluid mosaic model of the structure of cell membranes.
S. J. Singer,Garth L. Nicolson +1 more
TL;DR: Results strongly indicate that the bivalent antibodies produce an aggregation of the surface immunoglobulin molecules in the plane of the membrane, which can occur only if the immunoglOBulin molecules are free to diffuse in the membrane.
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Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface
Deborah A. Brown,John K. Rose +1 more
TL;DR: It is shown that a protein with a glycosylphosphatidyl inositol (GPI) anchor can be recovered from lysates of epithelial cells in a low density, detergent-insoluble form, supporting the model proposed by Simons and colleagues for sorting of certain membrane proteins to the apical surface after intracellular association with glycosphingolipids.
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Biological applications of optical forces
Karel Svoboda,Steven M. Block +1 more
TL;DR: Theories and Applications of Picotensiometry, Foundations of Trup Stiffness Measurements, and more.
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Confined lateral diffusion of membrane receptors as studied by single particle tracking (nanovid microscopy). Effects of calcium-induced differentiation in cultured epithelial cells.
TL;DR: In this article, the trajectories of E-cadherin, epidermal growth factor receptor, and transferrin receptor in the plasma membrane of a cultured mouse keratinocyte cell line were studied using both single particle tracking (SPT; nanovid microscopy) and fluorescence photobleaching recovery (FPR).
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Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin
TL;DR: Evidence is presented that implicates activation of the fibroblast growth factor receptor (FGFR) in the pathway underlying neurite outgrowth stimulated by L1, N-CAM, and N-cadherin, and a CAM homology domain in the FGF family of receptors is identified.