Ribosomal protein S7 is both a regulator and a substrate of MDM2
Yan Zhu,Masha V. Poyurovsky,Yingchun Li,Lynn Biderman,Joachim Stahl,Xavier Jacq,Carol Prives +6 more
TLDR
Ribosomal/nucleolar stress is likely a key integrating event in DNA damage signaling to p53, and S7 functions as both effector and affector of MDM2 to ensure a proper cellular response to different stress signals.About:
This article is published in Molecular Cell.The article was published on 2009-08-14 and is currently open access. It has received 206 citations till now. The article focuses on the topics: MDMX & Mdm2.read more
Citations
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Journal ArticleDOI
Signaling to p53: ribosomal proteins find their way.
Yanping Zhang,Hua Lu +1 more
TL;DR: The ribosomal protein-MDM2-p53 signaling pathway provides a molecular switch that may constitute a surveillance network monitoring the integrity of Ribosomal biogenesis.
Journal ArticleDOI
Ribosomal proteins: functions beyond the ribosome
TL;DR: The current understanding of how ribosomal stress provokes the accumulation of ribosome-free Ribosomal proteins, as well as the ribosomesome-independent functions of ribOSomal proteins in tumorigenesis, immune signaling, and development are overviewed.
Journal ArticleDOI
Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5. Vol. 279 (2004) 44475–44482
Mu-Shui Dai,Hua Lu +1 more
TL;DR: It is proposed that the MDM 2-L5-L11-L23 complex functions to inhibit MDM2-mediated p53 ubiquitination and thus activates p53.
Journal ArticleDOI
Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death
TL;DR: Therapeutic agents that target apoptotic regulatory proteins, including those that are part of the ubiquitin–proteasome system, might afford clinical benefits.
Journal ArticleDOI
The Mdm2–p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor
TL;DR: Growing evidence argues for p53-independent effects, as well as the remarkable possibility that Mdm2 has tumor suppressor functions in the appropriate context, which is proving to be a key player in human cancer in its own right, and thus an important target for therapeutic intervention.
References
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Journal ArticleDOI
The multifunctional nucleolus
TL;DR: Although the nucleolus is primarily associated with ribosome biogenesis, several lines of evidence now show that it has additional functions, such as regulation of mitosis, cell-cycle progression and proliferation, many forms of stress response and biogenesis of multiple ribonucleoprotein particles.
Journal ArticleDOI
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
Franck Toledo,Geoffrey M. Wahl +1 more
TL;DR: This Review of in vitro studies, human tumour data and recent mouse models shows that p53 post-translational modifications have modulatory roles, and MDM2 andMDM4 have more profound roles for regulating p53.
Journal ArticleDOI
Proteasome-Independent Functions of Ubiquitin in Endocytosis and Signaling
TL;DR: The proteasome-independent roles of ubiquitination in signaling and endocytosis are discussed, which are implicated in pathogenesis of some diseases, certain malignancies, neurodegenerative disorders, and pathologies of the inflammatory immune response.
Journal ArticleDOI
Nucleolar proteome dynamics
Jens S. Andersen,Yun Wah Lam,Anthony K.L. Leung,Shao En Ong,Carol E. Lyon,Angus I. Lamond,Matthias Mann +6 more
TL;DR: The data establish a quantitative proteomic approach for the temporal characterization of protein flux through cellular organelles and demonstrate that the nucleolar proteome changes significantly over time in response to changes in cellular growth conditions.
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Nucleolar Arf sequesters Mdm2 and activates p53.
Jason D. Weber,Jason D. Weber,Laura J. Taylor,Martine F. Roussel,Charles J. Sherr,Dafna Bar-Sagi,Dafna Bar-Sagi +6 more
TL;DR: It is shown that Arf binds to the product of the Mdm2 gene and sequesters it into the nucleolus, thereby preventing negative-feedback regulation of p53 by MDM2 and leading to the activation of p 53 in the nucleoplasm.
Related Papers (5)
Inhibition of MDM2-mediated p53 Ubiquitination and Degradation by Ribosomal Protein L5
Mu Shui Dai,Hua Lu +1 more