Role of lung pericytes and resident fibroblasts in the pathogenesis of pulmonary fibrosis.
Chi F. Hung,Geoffrey Linn,Yu Hua Chow,Akio Kobayashi,Kristen Mittelsteadt,William A. Altemeier,Sina A. Gharib,Lynn M. Schnapp,Jeremy S. Duffield +8 more
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TLDR
The lung contains an extensive population of Foxd1 progenitor-derived pericytes that are an important lung myofibroblast precursor population, and these studies suggest a distinct lineage of collagen-I(α)1-expressing resident fibroblasts that also expands after lung injury is a second major source of my ofibro Blasts.Abstract:
Rationale: The origin of cells that make pathologic fibrillar collagen matrix in lung disease has been controversial. Recent studies suggest mesenchymal cells may contribute directly to fibrosis.Objectives: To characterize discrete populations of mesenchymal cells in the normal mouse lung and to map their fate after bleomycin-induced lung injury.Methods: We mapped the fate of Foxd1-expressing embryonic progenitors and their progeny during lung development, adult homeostasis, and after fibrosing injury in Foxd1-Cre; Rs26-tdTomato-R mice. We studied collagen-I(α)1–producing cells in normal and diseased lungs using Coll-GFPTg mice.Measurements and Main Results: Foxd1-expressing embryonic progenitors enter lung buds before 13.5 days post-conception, expand, and form an extensive lineage of mesenchymal cells that have characteristics of pericytes. A collagen-I(α)1–expressing mesenchymal population of distinct lineage is also found in adult lung, with features of a resident fibroblast. In contrast to resident f...read more
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The perivascular origin of pathological fibroblasts
Selene Di Carlo,Lucie Peduto +1 more
TL;DR: Recent insights gained from the use of lineage tracing approaches in several organs point toward specific subsets of tissue-resident mesenchymal cells, mainly localized in a perivascular position, as the major source for collagen-producing cells after injury.
Journal ArticleDOI
Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis.
Ting Xie,Jiurong Liang,Ningshan Liu,Caijuan Huan,Yanli Zhang,Weijia Liu,Maya Kumar,Rui Xiao,Jeanine D'Armiento,Daniel Metzger,Pierre Chambon,Virginia E. Papaioannou,Barry R. Stripp,Dianhua Jiang,Paul W. Noble +14 more
TL;DR: In vivo lineage tracing and real-time gene expression transgenic reporting methods identify TBX4 as a mesenchymal transcription factor that drives accumulation of myofibroblasts and the development of lung fibrosis.
Journal ArticleDOI
FOXD1–ALDH1A3 Signaling Is a Determinant for the Self-Renewal and Tumorigenicity of Mesenchymal Glioma Stem Cells
Peng Cheng,Peng Cheng,Jia Wang,Jia Wang,Indrayani Waghmare,Stefania Sartini,Vito Coviello,Zhuo Zhang,Sung Hak Kim,Ahmed Mohyeldin,Marat S. Pavlyukov,Mutsuko Minata,Claudia L.L. Valentim,Rishi Raj Chhipa,Krishna P.L. Bhat,Biplab Dasgupta,Concettina La Motta,Madhuri Kango-Singh,Ichiro Nakano +18 more
TL;DR: A FOXD1-ALDH1A3 pathway is defined in controling the clonogenic and tumorigenic potential of MES GSC in glioblastoma tumors.
Journal ArticleDOI
Lung Pericytes and Resident Fibroblasts: Busy Multitaskers
TL;DR: The findings point to the importance of resident lung mesenchymal populations as therapeutic targets in acute lung injury as well as fibrotic and degenerative diseases.
Journal ArticleDOI
Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis.
Kenji Kobayashi,Jun Araya,Shunsuke Minagawa,Hiromichi Hara,Nayuta Saito,Tsukasa Kadota,Nahoko Sato,Masahiro Yoshida,Kazuya Tsubouchi,Yusuke Kurita,Saburo Ito,Yu Fujita,Naoki Takasaka,Hirofumi Utsumi,Haruhiko Yanagisawa,Mitsuo Hashimoto,Hiroshi Wakui,Jun Kojima,Kenichiro Shimizu,Takanori Numata,Makoto Kawaishi,Yumi Kaneko,Hisatoshi Asano,Makoto Yamashita,Makoto Odaka,Toshiaki Morikawa,Katsutoshi Nakayama,Kazuyoshi Kuwano +27 more
TL;DR: It is demonstrated that PARK2 knockdown-mediated mitophagy inhibition was involved in the mechanism for activation of the platelet-derived growth factor receptor (PDGFR)/PI3K/AKT signaling pathway accompanied by enhanced myofibroblast differentiation and proliferation, which were clearly inhibited by treatment with both antioxidants and AG1296, a PDGFR inhibitor.
References
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Journal ArticleDOI
Pericytes: developmental, physiological, and pathological perspectives, problems, and promises.
TL;DR: The history of investigations into pericytes, the mural cells of blood microvessels, are reviewed, emerging concepts are indicated, and problems and promise are pointed out.
Journal ArticleDOI
Endothelial/Pericyte Interactions
TL;DR: This review focuses on the advancement in recent years of the understanding of intercellular communication between endothelial and mural cells with a focus on transforming growth factor α, angiopoietins, platelet-derived growth factor, spingosine-1-phosphate, and Notch ligands and their respective receptors.
Journal ArticleDOI
The role of pericytes in blood-vessel formation and maintenance
Gabriele Bergers,Steven Song +1 more
TL;DR: This review article describes the current knowledge about the nature of pericytes and their functions during vessel growth, vessel maintenance, and pathological angiogenesis.
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Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis
Benjamin D. Humphreys,Benjamin D. Humphreys,Shuei-Liong Lin,Shuei-Liong Lin,Akio Kobayashi,Thomas E. Hudson,Brian T. Nowlin,Joseph V. Bonventre,Joseph V. Bonventre,M. Todd Valerius,Andrew P. McMahon,Jeremy S. Duffield,Jeremy S. Duffield +12 more
TL;DR: Data indicate that therapeutic strategies directly targeting pericyte differentiation in vivo may productively impact fibrotic kidney disease.
Journal ArticleDOI
Incidence and Prevalence of Idiopathic Pulmonary Fibrosis
TL;DR: The results suggest that idiopathic pulmonary fibrosis is probably more common in the United States than previously reported.
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