Journal ArticleDOI
Role of the mouse ank gene in control of tissue calcification and arthritis.
TLDR
It is shown that the mouse progressive ankylosis locus encodes a multipass transmembrane protein (ANK) that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells.Abstract:
Mutation at the mouse progressive ankylosis (ank) locus causes a generalized, progressive form of arthritis accompanied by mineral deposition, formation of bony outgrowths, and joint destruction. Here, we show that the ank locus encodes a multipass transmembrane protein (ANK) that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. A highly conserved gene is present in humans and other vertebrates. These results identify ANK-mediated control of pyrophosphate levels as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals.read more
Citations
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The serum protein α2–Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification
Cora Schäfer,Alexander Heiss,Anke Schwarz,Ralf Westenfeld,Markus Ketteler,Jürgen Floege,Werner Müller-Esterl,Thorsten Schinke,Willi Jahnen-Dechent +8 more
TL;DR: A critical role is demonstrated of the serum protein alpha2-Heremans-Schmid glycoprotein (Ahsg) as an inhibitor of unwanted mineralization and a novel therapeutic concept to prevent ectopic calcification accompanying various diseases is provided.
Journal ArticleDOI
Bisphosphonates: The first 40 years
TL;DR: The discovery and development of the bisphosphonates (BPs) as a major class of drugs for the treatment of bone diseases has been a fascinating story, and a paradigm of a successful journey from 'bench to bedside'.
Journal ArticleDOI
Vascular Calcification Pathobiology of a Multifaceted Disease
Linda L. Demer,Yin Tintut +1 more
TL;DR: Clinically, vascular calcification is now accepted as a valuable predictor of coronary heart disease, and, conversely, many treatments for cardiovascular disease such as statins, antioxidants, hormone replacement therapy, ACE inhibitors, fish oils, and calcium channel blockers may affect bone health.
Journal ArticleDOI
Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization
Lovisa Hessle,Kristen Johnson,H. Clarke Anderson,Sonoko Narisawa,Adnan Sali,James W. Goding,Robert Terkeltaub,José Luis Millán +7 more
TL;DR: The results suggest that inhibiting PC-1 function may be a viable therapeutic strategy for hypophosphatasia, and interfere with TNAP activity may correct pathological hyperossification because of PPi insufficiency.
Journal ArticleDOI
The mechanism of mineralization and the role of alkaline phosphatase in health and disease.
TL;DR: Although hypophosphatasia is untreatable at present, the recent success of enzyme replacement therapy offers promise, and strategies for preventing pathologic calcification using TNAP and NPP1 are in development.
References
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Journal ArticleDOI
Genetic influences on osteoarthritis in women: a twin study
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