ROS stress resets circadian clocks to coordinate pro-survival signals.
Teruya Tamaru,Mitsuru Hattori,Yasuharu Ninomiya,Genki Kawamura,Guillaume Vares,Kousuke Honda,Durga Prasad Mishra,Bing Wang,Ivor J. Benjamin,Paolo Sassone-Corsi,Takeaki Ozawa,Ken Takamatsu +11 more
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TLDR
A reactive oxygen species (ROS), H2O2 -responsive circadian pathway in mammals is identified and likely plays fundamental protective roles in various ROS-inducible disorders, diseases, and death.Abstract:
Dysfunction of circadian clocks exacerbates various diseases, in part likely due to impaired stress resistance. It is unclear how circadian clock system responds toward critical stresses, to evoke life-protective adaptation. We identified a reactive oxygen species (ROS), H2O2 -responsive circadian pathway in mammals. Near-lethal doses of ROS-induced critical oxidative stress (cOS) at the branch point of life and death resets circadian clocks, synergistically evoking protective responses for cell survival. The cOS-triggered clock resetting and pro-survival responses are mediated by transcription factor, central clock-regulatory BMAL1 and heat shock stress-responsive (HSR) HSF1. Casein kinase II (CK2) –mediated phosphorylation regulates dimerization and function of BMAL1 and HSF1 to control the cOS-evoked responses. The core cOS-responsive transcriptome includes CK2-regulated crosstalk between the circadian, HSR, NF-kappa-B-mediated anti-apoptotic, and Nrf2-mediated anti-oxidant pathways. This novel circadian-adaptive signaling system likely plays fundamental protective roles in various ROS-inducible disorders, diseases, and death.read more
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The mammalian circadian clock and its entrainment by stress and exercise
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References
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A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
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