Sars-Cov-2 Cell Entry Receptor Ace2 Mediated Endothelial Dysfunction Leads to Vascular Thrombosis in COVID-19 Patients
Ashutosh Kumar,Ravi K. Narayan,Chiman Kumari,Muneeb A. Faiq,Maheswari Kulandhasamy,Kamla Kant,Vikas Pareek +6 more
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TLDR
This work proposes a SARS-CoV-2 cell entry receptor ACE2 based mechanism for vascular thrombosis in COVID-19 patients, which is based on the circumstantial evidence present in the literature.About:
This article is published in Medical Hypotheses.The article was published on 2020-09-30 and is currently open access. It has received 49 citations till now. The article focuses on the topics: Endothelial dysfunction & Angiotensin-converting enzyme 2.read more
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Journal ArticleDOI
Endothelial Damage in Acute Respiratory Distress Syndrome.
TL;DR: The underlying pathology of endothelial dysfunction leading to ARDS and emerging therapies are discussed, and it is presented that endotheliopathy is an important feature of hospitalised patients with coronavirus disease-19 (COVID-19).
Journal ArticleDOI
SARS-CoV-2 Spike Protein Disrupts Blood-Brain Barrier Integrity via RhoA Activation.
Brandon J. DeOre,Kiet A. Tran,Allison M. Andrews,Servio H. Ramirez,Servio H. Ramirez,Peter A. Galie +5 more
TL;DR: In this article, a 3D-BBB microfluidic model was used to interrogate mechanisms by which the spike protein may facilitate barrier dysfunction, but its pathogenic mechanism of action is unknown.
Journal ArticleDOI
Therapeutic Potential of Metformin in COVID-19: Reasoning for Its Protective Role.
TL;DR: In this article, the authors discuss the multifaceted ability of metformin to control blood glucose levels and possibly attenuate endothelial dysfunction, inhibit viral entry and infection, and modify inflammatory and immune responses during SARS-CoV-2 infections.
Journal ArticleDOI
The Contribution of Endothelial Dysfunction in Systemic Injury Subsequent to SARS-Cov-2 Infection.
Jessica Maiuolo,Rocco Mollace,Micaela Gliozzi,Vincenzo Musolino,Cristina Carresi,Sara Paone,Miriam Scicchitano,Roberta Macrì,Saverio Nucera,Francesca Bosco,Federica Scarano,Maria Caterina Zito,Stefano Ruga,Annamaria Tavernese,Vincenzo Mollace +14 more
TL;DR: The review aims to assess some recent advances to define the crucial role of endothelial dysfunction in the pathogenesis of vascular complications accompanying SARS-CoV-2 infection and the molecular mechanisms associated with the interaction with the ACE2 receptor located on the endothelial cells are highlighted to support its role in compromising endothelial cell functionality.
Journal ArticleDOI
COVID-19 Mechanisms in the Human Body-What We Know So Far.
Ashutosh Kumar,Ravi K. Narayan,Pranav Prasoon,Chiman Kumari,Gurjot Kaur,Santosh Kumar,Maheswari Kulandhasamy,Kishore Sesham,Vikas Pareek,Muneeb A. Faiq,Sada N. Pandey,Himanshu Narayan Singh,Kamla Kant,Prakash Singh Shekhawat,Khursheed Raza,Sujeet Kumar +15 more
TL;DR: A review of the progress made since the commencement of the COVID-19 pandemic can be found in this article, where the authors narrate the progress in the human body, including virus-host interactions, pulmonary and other systemic manifestations, immunological dysregulations, complications, host-specific vulnerability, and long-term health consequences in the survivors.
References
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Endothelial cell infection and endotheliitis in COVID-19.
Zsuzsanna Varga,Andreas J. Flammer,Peter Steiger,Martina Haberecker,Rea Andermatt,Annelies S. Zinkernagel,Mandeep R. Mehra,Reto A. Schuepbach,Frank Ruschitzka,Holger Moch +9 more
TL;DR: The vascular endothelium is an active paracrine, endocrine, and Endothelial cell infection and endotheliitis in COVID-19 and recruitment of immune cells can result in widespread endothelial dysfunction associated with apoptosis.
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Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia.
TL;DR: In the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronvirus pneumonia (NCP) cases were a concern.
Journal ArticleDOI
Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19.
Maximilian Ackermann,Stijn E. Verleden,Mark Kuehnel,Axel Haverich,Tobias Welte,Florian Laenger,Arno Vanstapel,Christopher Werlein,Helge Stark,Alexandar Tzankov,William W. Li,Vincent W. Li,Steven J. Mentzer,Danny Jonigk +13 more
TL;DR: In this small series, vascular angiogenesis distinguished the pulmonary pathobiology of Covid-19 from that of equally severe influenza virus infection.
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Incidence of thrombotic complications in critically ill ICU patients with COVID-19.
Frederikus A. Klok,Marieke J. H. A. Kruip,N.J.M. van der Meer,M.S. Arbous,Diederik Gommers,K.M. Kant,F H J Kaptein,J. van Paassen,M A M Stals,Menno V. Huisman,Henrik Endeman +10 more
TL;DR: The findings reinforce the recommendation to strictly apply pharmacological thrombosis prophylaxis in all COVID-19 patients admitted to the ICU, and are strongly suggestive of increasing the prophYLaxis towards high-prophylactic doses, even in the absence of randomized evidence.
Journal ArticleDOI
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
Keiji Kuba,Yumiko Imai,Shuan Rao,Hong Gao,Feng Guo,Bin Guan,Yi Huan,Peng Yang,Yanli Zhang,Wei Deng,Linlin Bao,Binlin Zhang,Guang Liu,Zhong Wang,Mark C. Chappell,Yanxin Liu,Dexian Zheng,Andreas Leibbrandt,Teiji Wada,Arthur S. Slutsky,Depei Liu,Chuan Qin,Chengyu Jiang,Josef M. Penninger +23 more
TL;DR: A molecular explanation why SARS-CoV infections cause severe and often lethal lung failure and suggest a rational therapy for SARS and possibly other respiratory disease viruses is provided.