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Open AccessJournal ArticleDOI

Sensitivity Enhancement of Dual Gate FET Based Biosensor Using Modulated Dielectric for Covid Detection

Saurabh Kumar, +2 more
- 12 Apr 2022 - 
- Vol. 14, Iss: 17, pp 11453-11462
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TLDR
In this paper , a dual gate dielectric modulated FET (DGDMFET) biosensor with enhanced sensitivity for covid detection is presented. But the sensitivity of the proposed biosensor is limited due to the lack of surface interaction with the virus biomolecules reflected through a channel or gate.
Abstract
This paper presents a dual gate dielectric modulated FET (DGDMFET) biosensor with enhanced sensitivity for covid detection. In earlier literature, the biosensors are operated using the surface interaction with the virus biomolecules that are reflected through a channel or gate. The downside of these types of sensors has limited sensitivity. In this paper, we have considered that the change in the dielectric constant due to virus proteins results in a significant shift in the threshold voltage of FET. Enhancement of sensitivity is done by using the novel dual metal gate arrangement with different work functions (higher at the source end and lower at the drain end) and the chromic oxide (Cr2O3) layer, which is carved out vertically to form nanogap. At the same time, interface charge density is maintained nearly equal to 1.0 × 1011 cm−2 at the Si-SiO2 layer. To demonstrate the proposed biosensor, electrical parameters (electron concentration, surface potential, energy band distribution, and electric field) and the absolute percentage sensitivity of threshold voltage, subthreshold slope, ON current, and transconductance are evaluated and compared with related literature. The ATLAS device simulator is used for the simulation of the proposed device.

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Evaluation of dry stored disposable sensor strip on rapid SARS-CoV-2 detection platform

TL;DR: In this article , the authors investigated a SARS-CoV-2 virus detection mechanism using dry-stored disposable strips, which is as good as polymerase chain reaction (PCR) with a detection time of fewer than 30
References
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Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
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Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV.

TL;DR: It is shown that the SARS-CoV-2 spike protein is less stable than that of SARS -CoV, and limited cross-neutralization activities between SARS and COVID-19 patients’ sera showlimited cross- neutralization activities, suggesting that recovery from one infection might not protect against the other.
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Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19.

TL;DR: Recent research advance in the structure, function and development of antivirus drugs targeting the spike (S) protein of SARS-CoV-2 is highlighted.
Journal ArticleDOI

Covid-19 — Navigating the Uncharted

TL;DR: Covid-19 — Navigating the Uncharted Fauci, Lane, and Redfield comment on the early clinical features and epidemiology of cases reported in Wuhan, China, along with current mortality data, noting the importance of knowing the carrier and removal status of canine coronavirus.
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