Journal ArticleDOI
Serum miR-210 as a novel biomarker for molecular diagnosis of clear cell renal cell carcinoma
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TLDR
Serum miR-210 may have a potential as a novel noninvasive biomarker for the detection of cRCC.About:
This article is published in Experimental and Molecular Pathology.The article was published on 2013-02-01. It has received 133 citations till now. The article focuses on the topics: Clear cell renal cell carcinoma.read more
Citations
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Circulating miRNAs: roles in cancer diagnosis, prognosis and therapy.
TL;DR: This review highlights the current studies that focus on the identification of circulating miRNA-based diagnostic and prognostic markers, for the most prevalent types of cancer.
Journal ArticleDOI
Liquid biopsy: a step forward towards precision medicine in urologic malignancies
Ashley Di Meo,Ashley Di Meo,Jenni Bartlett,Jenni Bartlett,Yufeng Cheng,Maria D. Pasic,George M. Yousef,George M. Yousef +7 more
TL;DR: An overview of the current state of cell-free DNA-based kidney, prostate and bladder cancer biomarker research is provided and the potential utility other circulating molecules are discussed.
Journal ArticleDOI
The emerging role of extracellular vesicles as biomarkers for urogenital cancers
Muhammad Nawaz,Giovanni Camussi,Hadi Valadi,Irina Nazarenko,Karin M. Ekström,Xiaoqin Wang,Simona Principe,Neelam Shah,Naeem Mahmood Ashraf,Farah Fatima,Luciano Neder,Thomas Kislinger +11 more
TL;DR: A deeper understanding of the cargo molecules present in extracellular vesicles obtained from patients with urogenital cancers, through high-throughput proteomics or genomics approaches, will aid in the identification of novel diagnostic and prognostic biomarkers, and can potentially lead to the discovery of new therapeutic targets.
Journal ArticleDOI
New Concepts in Cancer Biomarkers: Circulating miRNAs in Liquid Biopsies
Erika Larrea,Carla Solé,Lorea Manterola,Ibai Goicoechea,María Armesto,María Arestin,María M. Caffarel,Angela M Araujo,Maria Araiz,Marta Fernandez-Mercado,Charles H. Lawrie,Charles H. Lawrie +11 more
TL;DR: One of the most promising classes of circulating cancer biomarkers: microRNAs (miRNAs) is reviewed, which means that cancer detection may be earlier and that the ability to monitor disease progression and/or treatment response represents a paradigm shift in the treatment of cancer patients.
Journal ArticleDOI
U6 is not a suitable endogenous control for the quantification of circulating microRNAs.
Mengqin Xiang,Ying Zeng,Ruirui Yang,Haifan Xu,Zhuo Chen,Jing Zhong,Hailong Xie,Yinghui Xu,Xi Zeng +8 more
TL;DR: It is suggested that U6 is unsuitable as an internal reference gene in the research of circulating miRNAs in serum subjected to different freeze-thaw cycles.
References
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Journal ArticleDOI
Circulating microRNAs as stable blood-based markers for cancer detection
Patrick S. Mitchell,Rachael K. Parkin,Evan M. Kroh,Brian R. Fritz,Brian R. Fritz,Stacia K. Wyman,Era L. Pogosova-Agadjanyan,Amelia Peterson,Jennifer Noteboom,Kathy O'Briant,April Allen,Daniel W. Lin,Daniel W. Lin,Daniel W. Lin,Nicole Urban,Charles W. Drescher,Beatrice S. Knudsen,Derek L. Stirewalt,Robert Gentleman,Robert L. Vessella,Robert L. Vessella,Peter S. Nelson,Daniel Martin,Daniel Martin,Muneesh Tewari +24 more
TL;DR: It is shown here that miRNAs are present in human plasma in a remarkably stable form that is protected from endogenous RNase activity and established the measurement of tumor-derived mi RNAs in serum or plasma as an important approach for the blood-based detection of human cancer.
Journal Article
Oncomirs : microRNAs with a role in cancer
TL;DR: I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators as discussed by the authors, and have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.
Journal ArticleDOI
Oncomirs — microRNAs with a role in cancer
TL;DR: Evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes.
Journal ArticleDOI
Prognostic significance of morphologic parameters in renal cell carcinoma.
TL;DR: Nuclear grade was the most significant prognostic criterion for the outcome of State I renal cell carcinoma, more effective than each of the other parameters in predicting development of distant metastasis following nephrectomy.
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