Sexual Dimorphisms: How Sex-Shared Neurons Generate Sex-Specific Behaviors
Reads0
Chats0
TLDR
Two new studies in C. elegans uncover novel molecular mechanisms that allow neurons shared by opposite sexes to generate distinct sex-specific behaviors in the brain.Citations
More filters
Journal ArticleDOI
Sexual Dimorphism of Gut Microbiota Dictates Therapeutics Efficacy of Radiation Injuries.
Ming Cui,Huiwen Xiao,Yuan Li,Shuqin Zhang,Jiali Dong,Bin Wang,Changchun Zhu,Mian Jiang,Tong Zhu,Junbo He,Haichao Wang,Saijun Fan +11 more
TL;DR: It is demonstrated that curative efficiencies of therapeutic strategies mitigating radiation toxicity might be dependent on the gender of patients, thus simvastatin or HFD might be specifically useful for fighting against radiation toxicity in a sex‐dependent fashion partly based on sex‐distinct gut microbiota composition in preclinical settings.
Journal ArticleDOI
Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner
Kang-Ying Qian,Wan-Xin Zeng,Wan-Xin Zeng,Yue Hao,Yue Hao,Xian-Ting Zeng,Haowen Liu,Lei Li,Lili Chen,Fu-min Tian,Fu-min Tian,Cindy Y. Chang,Qi Hall,Chun-Xue Song,Shangbang Gao,Zhitao Hu,Joshua M. Kaplan,Qian Li,Xia-Jing Tong +18 more
TL;DR: This study demonstrates a circuit mechanism for synaptic modulation and behavioral flexibility by sexual dimorphic pheromones in Caenorhabditis elegans, which alters hermaphrodites’ locomotion velocity and mating efficiency.
Posted ContentDOI
Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner
Kang-Ying Qian,Kang-Ying Qian,Wan-Xin Zeng,Wan-Xin Zeng,Yue Hao,Yue Hao,Xian-Ting Zeng,Haowen Liu,Lei Li,Lili Chen,Fu-min Tian,Cindy Y. Chang,Qi Hall,Chun-Xue Song,Shangbang Gao,Zhitao Hu,Joshua M. Kaplan,Qian Li,Xia-Jing Tong +18 more
TL;DR: In this article, the male pheromone increases the hermaphrodite cholinergic transmission at the neuromuscular junction (NMJ), which alters the locomotion velocity and mating efficiency in a developmental stage-dependent manner.
References
More filters
Journal ArticleDOI
The structure of the nervous system of the nematode Caenorhabditis elegans
TL;DR: The structure and connectivity of the nervous system of the nematode Caenorhabditis elegans has been deduced from reconstructions of electron micrographs of serial sections as discussed by the authors.
Journal ArticleDOI
The Connectome of a Decision-Making Neural Network
Travis A. Jarrell,Yi Wang,Adam Bloniarz,Christopher A. Brittin,Meng Xu,J. Nichol Thomson,Donna G. Albertson,David H. Hall,Scott W. Emmons +8 more
TL;DR: The wiring diagram of the posterior nervous system of the C. elegans adult male is presented, reconstructed from serial electron micrograph sections, which shows how the network robustly and rapidly selects and executes the steps of a behavioral program on the basis of the inputs from multiple sensory neurons.
Journal ArticleDOI
Netrins: versatile extracellular cues with diverse functions.
TL;DR: The mechanisms involved in netrin signalling in vertebrate and invertebrate systems are reviewed and the functions ofNetrin signalling during the development of neural and non-neural tissues are discussed.
Journal ArticleDOI
A blend of small molecules regulates both mating and development in Caenorhabditis elegans
Jagan Srinivasan,Fatma Kaplan,Fatma Kaplan,Ramadan Ajredini,Ramadan Ajredini,Cherian Zachariah,Cherian Zachariah,Hans T. Alborn,Peter E. A. Teal,Rabia U. Malik,Arthur S. Edison,Arthur S. Edison,Paul W. Sternberg,Frank C. Schroeder +13 more
TL;DR: The mating signal in C. elegans consists of a synergistic blend of three dauer-inducing ascarosides, which are demonstrated to be strongly synergistic, and to connect reproductive and developmental pathways and represents a unique example of structure- and concentration-dependent differential activity of signalling molecules.
Journal ArticleDOI
Neuromodulatory state and sex specify alternative behaviors through antagonistic synaptic pathways in C. elegans.
Heeun Jang,Kyuhyung Kim,Kyuhyung Kim,Scott J. Neal,Evan Z. Macosko,Dongshin Kim,Rebecca A. Butcher,Danna M. Zeiger,Cornelia I. Bargmann,Piali Sengupta +9 more
TL;DR: It is shown that distinct behavioral responses arise from overlapping push-pull circuits driven by two classes of pheromone-sensing neurons, one of which is attractive, repulsive, or neutral to wild-type hermaphrodites.