Journal ArticleDOI
Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics
Josephine R. Giles,Shin Foong Ngiow,Sasikanth Manne,Amy E. Baxter,Omar Khan,Ping Wang,Ryan P. Staupe,Mohamed S. Abdel-Hakeem,Hua Huang,Divij Mathew,Mark M. Painter,Jennifer E. Wu,Yinghui Jane Huang,Rishi R. Goel,Patrick Yan,Giorgos C. Karakousis,Xiaowei Xu,Tara C. Mitchell,Alexander C. Huang,E. John Wherry +19 more
Reads0
Chats0
TLDR
New subsets are uncovered, including a subpopulation of Tex cells expressing natural killer cell-associated genes that is dependent on the transcription factor Zeb2, as well as multiple distinct TCF-1+ stem/progenitor-like subsets in acute and chronic infection.Citations
More filters
Journal ArticleDOI
Advancing beyond the twists and turns of T cell exhaustion in cancer
TL;DR: In this paper , the heterogeneity and dynamics of exhausted CD8 T cells are studied to guide novel therapies that modulate T cell differentiation to achieve more effective antitumor responses, which will help inform new therapies.
Journal ArticleDOI
Orthogonal cytokine engineering enables novel synthetic effector states escaping canonical exhaustion in tumor-rejecting CD8+ T cells
Jesus Corria-Osorio,Santiago J. Carmona,E Stefanidis,Massimo Andreatta,Yaquelin Ortiz-Miranda,T. Muller,Ioanna A. Rota,Isaac Crespo,Bili Seijo,Wilson Castro,Cristina Jiménez-Luna,Leonardo Scarpellino,Catherine Ronet,Aodrenn Spill,Evripidis Lanitis,Pedro Romero,Sanjiv A. Luther,Melita Irving,George Coukos +18 more
TL;DR: In this paper , orthogonal gene engineering of T cells to secrete an interleukin (IL)-2 variant binding the IL-2Rβγ receptor and the alarmin IL-33 were adopted to acquire a novel, synthetic effector state.
Journal ArticleDOI
Anti-GD2 CAR-NKT cells in relapsed or refractory neuroblastoma: updated phase 1 trial interim results
Andras Heczey,Xin Xu,Amy N. Courtney,Gengwen Tian,Gabriel A. Barragan,Linjie Guo,C M Amador,Nisha Ghatwai,Purva Rathi,Michael Scott Wood,Chunmei Zhang,Thorsten Demberg,Erica J Di Pierro,Andrew Sher,Huibin Zhang,Birju Mehta,Sachin G. Thakkar,Bambi Grilley,Tao Wang,Brian Weiss,Antonino Montalbano,Meena Subramaniam,Chenling Xu,Chirag Sachar,Daniel K. Wells,Gianpietro Dotti,Leonid S. Metelitsa +26 more
Journal ArticleDOI
Localization, tissue biology and T cell state - implications for cancer immunotherapy.
Journal ArticleDOI
Fundamentals to therapeutics: Epigenetic modulation of CD8+ T Cell exhaustion in the tumor microenvironment
TL;DR: In this paper , the background of T cell differentiation and various exhaustion states and how epigenetics play an important role in these processes are discussed and the most recent methodologies that are used to study and discover such epigenetic modulations.
References
More filters
Journal ArticleDOI
Lineage relationship and protective immunity of memory CD8 T cell subsets.
E. John Wherry,Volker Teichgräber,Todd C. Becker,David Masopust,Susan M. Kaech,Rustom Antia,Ulrich H. von Andrian,Rafi Ahmed +7 more
TL;DR: It is proposed that TCM and TEM do not necessarily represent distinct subsets, but are part of a continuum in a linear naive → effector → TEM → TCM differentiation pathway.
Journal ArticleDOI
Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
TL;DR: Increased expression of the interleukin 7 receptor α-chain (IL-7Rα) identifies the effector CD8 T cells that will differentiate into memory cells, and this marker may be useful in predicting the number of memory T cells generated after infection or immunization.
Journal ArticleDOI
Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor.
Nikhil S. Joshi,Weiguo Cui,Anmol Chandele,Heung Kyu Lee,David Urso,James Hagman,Laurent Gapin,Susan M. Kaech +7 more
TL;DR: A mechanism by which the innate immune system sets the relative amounts of a lineage-determining transcription factor in activated CD8(+) T cells and regulates their memory cell potential is elucidated.
Journal ArticleDOI
Defining CD8 + T cells that provide the proliferative burst after PD-1 therapy
Se Jin Im,Masao Hashimoto,Michael Y. Gerner,Michael Y. Gerner,Junghwa Lee,Haydn T. Kissick,Matheus Carvalho Bürger,Qiang Shan,J. Scott Hale,Judong Lee,Tahseen H. Nasti,Arlene H. Sharpe,Arlene H. Sharpe,Gordon J. Freeman,Ronald N. Germain,Helder I. Nakaya,Hai-Hui Xue,Rafi Ahmed +17 more
TL;DR: A population of virus-specific CD8+ T cells that proliferate after blockade of the PD-1 inhibitory pathway in mice chronically infected with lymphocytic choriomeningitis virus is identified and its findings provide a better understanding of T-cell exhaustion and have implications in the optimization of PD- 1-directed immunotherapy in chronic infections and cancer.
Journal ArticleDOI
The energetics of genome complexity
Nick Lane,William Martin +1 more
TL;DR: The endosymbiosis that gave rise to mitochondria restructured the distribution of DNA in relation to bioenergetic membranes, permitting a remarkable 200,000-fold expansion in the number of genes expressed.